4.8 Article

Nucleolar HEAT Repeat Containing 1 Up-regulated by the Mechanistic Target of Rapamycin Complex 1 Signaling Promotes Hepatocellular Carcinoma Growth by Dominating Ribosome Biogenesis and Proteome Homeostasis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Role of Nrf2 in Pancreatic Cancer

Marta Cykowiak et al.

Summary: Pancreatic tumors are a serious health issue with a high mortality rate. Inflammation and oxidative stress play crucial roles in their development. Maintaining a balance between free radicals and the antioxidant system is essential for homeostasis. The Nrf2 signaling pathway is being explored as a potential target for pancreatic disease treatment. This review presents the latest evidence on the activation of the Nrf2 signaling pathway and its importance in pancreatic cancer, as well as recent discoveries of novel treatments related to the antioxidant system.

ANTIOXIDANTS (2022)

Article Gastroenterology & Hepatology

Nrf2 Mutation/Activation Is Dispensable for the Development of Chemically Induced Mouse HCC

Sandra Mattu et al.

Summary: The study revealed the absence of Nrf2 gene mutations in chemically induced mouse HCC models, unlike in rat hepatocarcinogenesis. Interestingly, there was no evidence of Nrf2 activation in early dysplastic nodules and HCCs with beta-catenin mutations, and metabolic reprogramming was not observed. These findings suggest that Nrf2 activation plays a critical role in the switch from oxidative to glycolytic metabolism.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

Article Multidisciplinary Sciences

Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome

Hua Su et al.

Summary: This study reveals the opposing effects of intact and cleaved collagen I (Col I) in regulating the bioenergetics, tumor growth, and metastasis of pancreatic ductal adenocarcinoma (PDAC) through the tumor microenvironment. Intact Col I inhibits tumor growth, while cleaved Col I promotes tumor growth. Patients with tumors enriched in intact Col I and low levels of related signaling molecules have a longer median survival. These findings shed light on the complex mechanisms of the tumor microenvironment in PDAC and provide new therapeutic targets.

NATURE (2022)

Review Gastroenterology & Hepatology

Role of the Mammalian Target of Rapamycin Pathway in Liver Cancer: From Molecular Genetics to Targeted Therapies

Xinjun Lu et al.

Summary: Primary liver cancers, including HCC and iCCA, are highly lethal tumors with limited treatment options. The mTOR complex is a central regulator of cell growth and metabolism and plays a key role in liver-tumor development and progression. Current research aims to develop more effective mTOR inhibitors for liver-cancer treatment.

HEPATOLOGY (2021)

Review Cell Biology

The nucleolus as a multiphase liquid condensate

Denis L. J. Lafontaine et al.

Summary: The nucleolus is a membraneless organelle involved in ribonucleoprotein assembly, with recent studies suggesting that it forms as a biomolecular condensate via liquid-liquid phase separation (LLPS). Insights from LLPS studies are enhancing our understanding of the nucleolar structure-function relationship.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Letter Biochemistry & Molecular Biology

PARP inhibitor Olaparib overcomes Sorafenib resistance through reshaping the pluripotent transcriptome in hepatocellular carcinoma

Xiao-Dong Yang et al.

Summary: PARP1 plays important roles in stem cell pluripotency and HCC sorafenib treatment resistance. Overexpression of PARP1 is closely associated with poor clinical outcome in HCC patients. Olaparib suppresses DNA damage repair signaling and the global pluripotent transcriptional network, enhancing sorafenib in eliminating HCC residual tumors.

MOLECULAR CANCER (2021)

Article Multidisciplinary Sciences

Eukaryotic initiation factor 2 signaling behind neural invasion linked with lymphatic and vascular invasion in pancreatic cancer

Taiichi Wakiya et al.

Summary: In this study, it was found that perineural invasion (PNI) in early-stage PDAC is associated with lymphatic and vascular invasion, and dysregulation of proteostasis and ribosome biogenesis may affect the severity of PNI.

SCIENTIFIC REPORTS (2021)

Article Oncology

Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis

Hua Su et al.

Summary: Although many cancers rely on autophagy for nutrient acquisition, blocking autophagy alone does not effectively inhibit tumor growth. Research has shown that blocking autophagy can lead to pancreatic ductal adenocarcinoma (PDAC) upregulating an alternative nutrient pathway, macropinocytosis (MP), allowing tumor cells to extract nutrients from outside sources. This switch from autophagy to MP, driven by the activation of transcription factor NRF2, presents a potential therapeutic strategy for inhibiting tumor growth and regression.

CANCER CELL (2021)

Article Biochemistry & Molecular Biology

HEATR1, a novel interactor of Pontin/Reptin, stabilizes Pontin/Reptin and promotes cell proliferation of oral squamous cell carcinoma

Akihiko Nakamura et al.

Summary: Pontin and Reptin are closely related proteins that form a complex involved in protein stability and assembly. HEATR1 has been identified as a novel binding factor of Pontin/Reptin, positively regulating OSCC cell proliferation. HEATR1 is proposed to be involved in the regulation of mTOR and ribosome biogenesis in OSCC as a potential protein stabilizer of Pontin/Reptin.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Gastroenterology & Hepatology

Cooperation Between the NRF2 Pathway and Oncogenic β-catenin During HCC Tumorigenesis

Mathilde Savall et al.

Summary: CTNNB1-mutated hepatocellular carcinomas show high levels of respiratory chain activity and an enrichment of the NRF2 pathway. Pharmacological inactivation of Nrf2 considerably decreases the progression of beta-catenin-dependent HCC development, demonstrating the relevance of targeting redox balance as a therapeutic strategy in CTNNB1-mutated HCC.

HEPATOLOGY COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Stress- and ubiquitylation-dependent phase separation of the proteasome

Sayaka Yasuda et al.

NATURE (2020)

Article Multidisciplinary Sciences

Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors

Chen Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Biochemistry & Molecular Biology

HEATR1 promotes proliferation in gastric cancer in vitro and in vivo

Jun Zhao et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2020)

Article Biotechnology & Applied Microbiology

HEATR1 modulates cell survival in non-small cell lung cancer via activation of the p53/PUMA signaling pathway

Saifei He et al.

ONCOTARGETS AND THERAPY (2019)

Article Multidisciplinary Sciences

Inducing and exploiting vulnerabilities for the treatment of liver cancer

Cun Wang et al.

NATURE (2019)

Article Pharmacology & Pharmacy

Ribosome biogenesis: An emerging druggable pathway for cancer therapeutics

Frederic Catez et al.

BIOCHEMICAL PHARMACOLOGY (2019)

Review Biochemistry & Molecular Biology

Ribosomal DNA and the nucleolus in the context of genome organization

Tamara A. Potapova et al.

CHROMOSOME RESEARCH (2019)

Article Biochemistry & Molecular Biology

c-MYC G-quadruplex binding by the RNA polymerase I inhibitor BMH-21 and analogues revealed by a combined NMR and biochemical Approach

Loana Musso et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2018)

Review Medicine, General & Internal

Hepatocellular carcinoma

Alejandro Forner et al.

LANCET (2018)

Review Oncology

Ribosome biogenesis in cancer: new players and therapeutic avenues

Joffrey Pelletier et al.

NATURE REVIEWS CANCER (2018)

Review Biochemistry & Molecular Biology

The biology of Hepatocellular carcinoma: implications for genomic and immune therapies

Galina Khemlina et al.

MOLECULAR CANCER (2017)

Review Biochemistry & Molecular Biology

Nucleophosmin: from structure and function to disease development

Joseph K. Box et al.

BMC MOLECULAR BIOLOGY (2016)

Review Biochemistry & Molecular Biology

Touch and go: nuclear proteolysis in the regulation of metabolic genes and cancer

Laure Maneix et al.

FEBS LETTERS (2016)

Article Multidisciplinary Sciences

An evolutionarily conserved pathway controls proteasome homeostasis

Adrien Rousseau et al.

NATURE (2016)

Article Multidisciplinary Sciences

UtpA and UtpB chaperone nascent pre-ribosomal RNA and U3 snoRNA to initiate eukaryotic ribosome assembly

Mirjam Hunziker et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

The HBx oncoprotein of hepatitis B virus engages nucleophosmin to promote rDNA transcription and cellular proliferation

Richa Ahuja et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)

Review Biochemistry & Molecular Biology

Sp1 and the 'hallmarks of cancer'

Kate Beishline et al.

FEBS JOURNAL (2015)

Review Pharmacology & Pharmacy

Sp1 transcription factor: A long-standing target in cancer chemotherapy

Carolina Vizcaino et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Article Biochemistry & Molecular Biology

Upstream binding factor-dependent and pre-rRNA transcription-independent association of pre-rRNA processing factors with rRNA gene

Shuhei Ueshima et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Review Gastroenterology & Hepatology

Targeting the mTOR pathway in hepatocellular carcinoma: Current state and future trends

Matthias S. Matter et al.

JOURNAL OF HEPATOLOGY (2014)

Review Cell Biology

mTORC1 signaling controls multiple steps in ribosome biogenesis

Valentina Iadevaia et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2014)

Article Cell Biology

In silico discovery of novel transcription factors regulated by mTOR-pathway activities

Agnieszka Jablonska et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro

Eun-Ang Raiber et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Cell Biology

The small subunit processome in ribosome biogenesis-progress and prospects

Kathleen R. Phipps et al.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2011)

Review Pharmacology & Pharmacy

The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer

Denis Drygin et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2010)

Review Oncology

MYC as a regulator of ribosome biogenesis and protein synthesis

Jan van Riggelen et al.

NATURE REVIEWS CANCER (2010)

Article Gastroenterology & Hepatology

Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma

Augusto Villanueva et al.

GASTROENTEROLOGY (2008)

Article Multidisciplinary Sciences

Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation

Zhaoliang Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Oncology

Does the ribosome translate cancer?

D Ruggero et al.

NATURE REVIEWS CANCER (2003)

Article Biochemistry & Molecular Biology

Two consecutive zinc fingers in Sp1 and in MAZ are essential for interactions with cis-elements

J Song et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)