期刊
FUTURE MICROBIOLOGY
卷 -, 期 -, 页码 -出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2022-0202
关键词
1; 10-phenanthroline; antifungal resistance; biofilm; chemotherapy; coordination compounds; Scedosporium; Lomentospora
类别
This study tested the effects of 16 metal-based compounds on human pathogens belonging to the Scedosporium/Lomentospora genera. All 16 compounds interfered with the viability of these fungal pathogens to different degrees. A manganese-containing compound showed the best activity against the fungal species and had the least toxicity to human lung cells. Additionally, it reduced the formation of biofilms by these fungi.
Plain language summaryMetals have been used to treat microbial infections for centuries. In this context, the effects of 16 metal-based compounds against the human pathogens Scedosporium apiospermum, Scedosporium minutisporum, Scedosporium aurantiacum and Lomentospora prolificans were tested. All the 16 metal-based compounds were able to interfere with the viability of these fungal pathogens to different degrees. Among the 16 compounds, a manganese-containing compound presented the best activity against the fungal species and it presented the least toxicity to a human lung cell line. In addition, this manganese-containing compound reduced the ability of fungal cells to come together and form a type of community called biofilm. In conclusion, the manganese-containing compound presents a promising option against the multidrug-resistant filamentous fungi species belonging to the Scedosporium/Lomentospora genera. Background: Scedosporium/Lomentospora species are human pathogens resistant to almost all antifungals currently available in clinical practice. Methods: The effects of 16 1,10-phenanthroline (phen)/1,10-phenanthroline-5,6-dione/dicarboxylate chelates containing Cu(II), Mn(II) and Ag(I) against Scedosporium apiospermum, Scedosporium minutisporum, Scedosporium aurantiacum and Lomentospora prolificans were evaluated. Results: To different degrees, all of the test chelates inhibited the viability of planktonic conidial cells, displaying MICs ranging from 0.029 to 72.08 mu M. Generally, Mn(II)-containing chelates were the least toxic to lung epithelial cells, particularly [Mn-2(oda)(phen)(4)(H2O)(2)][Mn-2(oda)(phen)(4)(oda)(2)].4H(2)O (MICs: 1.62-3.25 mu M: selectivity indexes >64). Moreover, this manganese-based chelate reduced the biofilm biomass formation and diminished the mature biofilm viability. Conclusion: [Mn-2(oda)(phen)(4)(H2O)(2)][Mn-2(oda)(phen)(4)(oda)(2)].4H(2)O opens a new chemotherapeutic avenue for the deactivation of these emergent, multidrug-resistant filamentous fungi.
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