Recent advances in quinolone hybrids with potential antibacterial activity against drug-resistant bacteria

Quinolone derivatives, represented by fluoroquinolones, have emerged as the most commonly prescribed antibacterials for the treatment of various bacterial infections. In particular, the combination of a quinolone moiety with other antibacterial pharmacophores has the potential to act on different drug targets, which in turn, overcome drug resistance. Accordingly, quinolone hybrids are useful prototypes for fighting drug-resistant pathogens. The purpose of the present review is to provide an emphasis on the current scenario of quinolone hybrids with potential antibacterial activity against drug-resistant pathogens, covering articles published in the past 10 years. The structure-activity relationships, various aspects of rational design and mechanisms of action are also discussed to facilitate further rational development of more effective candidates.

Automated summary

Quinolone derivatives, especially fluoroquinolones, are widely prescribed antibiotics for treating bacterial infections. Combining quinolone with other antibacterial pharmacophores can target different drug resistance mechanisms. Quinolone hybrids are valuable prototypes in combating drug-resistant pathogens. This review focuses on recent articles within the past 10 years, highlighting the antibacterial activity of quinolone hybrids against drug-resistant pathogens. It also discusses structure-activity relationships, rational design, and mechanisms of action to further facilitate the development of more effective candidates.