4.7 Article

Ultrasound sensitive O2 microbubbles radiosensitize murine breast cancer but lead to higher metastatic spread

期刊

FREE RADICAL BIOLOGY AND MEDICINE
卷 199, 期 -, 页码 166-176

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2023.02.022

关键词

Oxygen microbubbles; Hypoxia; Radiotherapy; EPR imaging

向作者/读者索取更多资源

The inadequate oxygenation in tumors is associated with increased invasiveness of cancer cells and reduced sensitivity to anticancer therapies. Attempts to increase tumor oxygenation have been largely ineffective. The use of phospholipid-coated oxygen microbubbles (OMB) can increase tumor oxygenation, but it also affects tumor vasculature and promotes cancer cell spread.
The inadequate level of oxygenation in tumors has been shown to correlate not only with greater invasiveness of cancer cells, but also with a reduction in their sensitivity to anticancer therapies. Over the years, many attempts have been made to increase the oxygenation level of cancer, but most of them have been ineffective. We investigated the heterogeneous response of tumor tissue to phospholipid-coated oxygen microbubbles (OMB) in murine tumors in vivo using oxygen and hemoglobin saturation mapping and the influence of OMB treatment on microvasculature, perfusion, and radiotherapy effectiveness. Intravenous administration of OMB followed by ultrasound pulse leads to increased oxygenation of a tumor, found mainly in the vicinity of tumor vessels, while intratumoral delivery resulted in areas of increased pO2 more evenly distributed within the tumor. Furthermore, hemoglobin contributes little to the increase in tumor oxygenation caused by oxygen microbubbles. Extensive vasculature disruption was observed in the groups treated with both oxygen/nitrogen microbubbles and ultra -sound pulse. This therapy also led to a reduction in the coverage of the vessels by pericytes, while the density of the microvessels was unchanged. Radiotherapy with a single dose of 12Gy reduced tumor growth by 50% in all treated groups. Unfortunately, at the same time, the number of macroscopic metastases in the lungs increased significantly after intravenous administration of oxygen/nitrogen microbubbles and the application of an ul-trasound pulse. In conclusion, ultrasound-sensitive oxygen microbubbles are effective in delivering oxygen to tumor tissue, thus increasing the effectiveness of radiotherapy. However, cavitation effects and destruction of the integrity of tumor vessels result in greater spread of cancer cells in the host organism.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据