Identification of characteristic markers for monofloral honey of Astragalus membranaceus var. mongholicus Hsiao: A combined untargeted and targeted MS-based study

Article Chemistry, Applied

Improved water solubility, chemical stability, antioxidant and anticancer activity of resveratrol via nanoencapsulation with pea protein nanofibrils

Jiang Yi et al.

Summary: Fabricated pea protein isolate nanofibrils can be used as nanocarriers to improve water solubility, antioxidant capacity, and antiproliferative activities of hydrophobic nutraceuticals.

FOOD CHEMISTRY (2022)

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Article Chemistry, Applied

Sequential changes in antioxidant activity and structure of curcumin-myofibrillar protein nanocomplex during in vitro digestion

Changling Wu et al.

Summary: This study investigated the in vitro digestion of curcumin-myofibrillar protein (MP) complexes and found that the nanocomplexes significantly enhanced the release of protein and the scavenging of free radicals. Additionally, curcumin can alter the protein structure during digestion, leading to changes in the composition of the digested products.

FOOD CHEMISTRY (2022)

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Article Food Science & Technology

Kaempferol-3-O-galactoside as a marker for authenticating Lespedeza bicolor Turcz. monofloral honey

Caijun Ren et al.

Summary: This study characterized the physicochemical parameters and palynological characteristics of Lespedeza bicolor honey, and established a screening method for authenticating L. bicolor honey. Mass spectrometry analysis identified kaempferol-3-O-galactoside as a candidate chemical marker for L. bicolor honey.

FOOD RESEARCH INTERNATIONAL (2022)

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Article Pharmacology & Pharmacy

Astragalus mongholicus Bunge Water Extract Exhibits Anti-inflammatory Effects in Human Neutrophils and Alleviates Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice

Wei-Jen Cheng et al.

Summary: The water extract of Astragalus mongholicus Bunge (AWE) demonstrated anti-inflammatory effects by directly inhibiting human neutrophil activation and anti-psoriatic effects in mice with IMQ-induced psoriasis-like skin inflammation.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Mechanism of Radix Astragali and Radix Salviae Miltiorrhizae Ameliorates Hypertensive Renal Damage

Guangjian Hou et al.

Summary: The combination of Radix Astragali (RA) and Radix Salviae Miltiorrhizae (RS) can improve hypertension-induced renal damage (HRD) by regulating renal sympathetic nerve, reducing vascular resistance, lowering levels of neurotransmitters, protecting the cardiovascular system, and alleviating kidney pathology.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Chemistry, Applied

Proteomic analysis of honey. Identification of unique peptide markers for authentication of NZ manuka (Leptospermum scoparium) honey

Jessie Bong et al.

Summary: This study utilized proteomics to analyze the protein components of ma?nuka honey, identifying 50 bee-derived proteins with major royal jelly proteins as the predominant ones. Unique nectar-derived proteins in ma?nuka honey were also discovered, along with the presence of plant proteins and proteins related to drought tolerance. Authentication markers were proposed based on the uniqueness of certain peptides, showcasing peptide profiling as a novel approach for ma?nuka honey authentication.

FOOD CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Antioxidant activity of calycosin against α-synuclein amyloid fibrils-induced oxidative stress in neural-like cells as a model of preventive care studies in Parkinson's disease

Qichen Pan et al.

Summary: The study demonstrated that calycosin significantly inhibits the fibril formation of α-syn in a concentration-dependent manner, preventing α-syn amyloid-triggered neurotoxicity. By modifying the aggregation pathway, calycosin promotes the formation of non-toxic species, restoring SOD/CAT activity and GSH content while reducing ROS levels and caspase-3 activity. This research provides valuable insights into the mechanism of α-syn amyloid inhibition by calycosin and suggests the development of small molecules-based therapeutic platforms for Parkinson's disease.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Multidisciplinary Sciences

Major bioactive chemical compounds in Astragali Radix samples from different vendors vary greatly

Bijay Kafle et al.

Summary: The study evaluated the influence of different sample types, preparation methods, and ammonia treatment on concentrations of bioactive molecules in Astragali Radix. Results showed significant differences in bioactive molecules concentrations depending on sample types, extraction processes, and ammonia treatment. Routine quantitative analysis of major bioactive compounds in Astragali Radix can help ensure quality control and guarantee the quality of commercial products.

PLOS ONE (2021)

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Article Pharmacology & Pharmacy