期刊
FOOD CHEMISTRY
卷 404, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2022.134405
关键词
Proanthocyanidins; Obesity; Inflammation; Gut microbiota; White adipose tissue; TLR4 pathway
Several factors can impact the gut microbiota, affecting host metabolism and immunity. Grape seed proanthocyanidins extract (GSPE) has potential effects on the gut microbiota-white adipose tissue axis against obesity by improving intestinal permeability and microbial diversity, decreasing LPS levels, and modulating the TLR-4 pathway.
Several factors can impact the gut microbiota, affecting host metabolism and immunity. It implies intestinal barrier disruption and translocation of gut microbiota metabolites to the bloodstream, such as lipopolysaccha-rides (LPS). LPS is an endotoxin from gram-negative gut bacteria that trigger the activation of the Toll-like re-ceptor-4 (TLR-4) inflammatory pathway and can modulate white adipose tissue (WAT) metabolism. Dietary components, including diets rich in fiber and polyphenols, contribute to intestinal environment homeostasis. Grape seed proanthocyanidins extract (GSPE) may improve intestinal permeability and microbial diversity and increase short-chain fatty acids production. Furthermore, GSPE has been involved in LPS reduction, down -regulating the TLR-4 pathway, decreasing the WAT metainflammatory profile, and preventing adipocyte hy-pertrophy. Studies have pointed out strategies to promote health and control obesity by modulating the gut microbiota environment. Therefore, this review aims to summarize the potential effects of GSPE on the gut microbiota-white adipose tissue axis against obesity.
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