期刊
FISH & SHELLFISH IMMUNOLOGY
卷 137, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2023.108739
关键词
Ulceration; Lesion; Fish skin; Gene expression; Chinook salmon; Wound healing
This study investigated the relationship between ulcers and stress, immune, and structural gene expression in farmed Chinook salmon skin in New Zealand. The findings revealed that fish with ulcers showed signs of stress, inflammation, re-epithelization, and delayed healing near the ulcer site, emphasizing the importance of these processes in the pathogenesis of ulcers.
Fish skin is critical to physical defence against pathogens and there is a need to understand the physiological processes impacting ulcers and their healing. Ulcers have been reported in farmed Chinook salmon in New Zealand. This study investigated stress, immune and structural gene expression in farmed Chinook salmon skin with and without ulcers from two sites in New Zealand sampled from February (higher temperature, late sum -mer) to May (lower temperature, late autumn). Skin samples taken adjacent to non-specific ulcers in May and control fish in February demonstrated upregulation of heat shock protein 70 relative to control fish in May. Anterior gradient 2 expression was upregulated in fish with ulcers relative to control fish (both February and May), suggesting increased mucous cell activity. Based on the results of this study, fish with non-specific ulcers showed evidence of stress, inflammation, re-epithelisation, and delayed healing near the ulcer site, elucidating the importance of these processes in the pathogenesis of non-specific ulcers in farmed chinook salmon.
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