相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors
Lick Pui Lai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)
A Structure Is Worth a Thousand Words: New Insights for RAS and RAF Regulation
Dhirendra K. Simanshu et al.
CANCER DISCOVERY (2022)
Expanding the molecular spectrum of pathogenic SHOC2 variants underlying Mazzanti syndrome
Marialetizia Motta et al.
HUMAN MOLECULAR GENETICS (2022)
Polycistronic baculovirus expression of SUGT1 enables high-yield production of recombinant leucine-rich repeat proteins and protein complexes
Kelly Snead et al.
PROTEIN EXPRESSION AND PURIFICATION (2022)
Case report: A de novo RASopathy-causing SHOC2 variant in a Chinese girl with noonan syndrome-like with loose anagen hair
Qingming Wang et al.
FRONTIERS IN GENETICS (2022)
Structural keys unlock RAS-MAPK signalling
Hugo Lavoie et al.
NATURE (2022)
Structural basis for SHOC2 modulation of RAS signalling
Nicholas P. D. Liau et al.
NATURE (2022)
Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex
Jason J. Kwon et al.
NATURE (2022)
Structure of the MRAS-SHOC2-PP1C phosphatase complex
Zachary J. Hauseman et al.
NATURE (2022)
Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome
Daniel A. Bonsor et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2022)
SHOCing RAF into action
Helen R. Mott et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2022)
Case report: Identification and clinical phenotypic analysis of novel mutation of the PPP1CB gene in NSLH2 syndrome
Xuemei He et al.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2022)
The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease
HyeIn Jang et al.
FEBS JOURNAL (2021)
Towards Dissecting the Mechanism of Protein Phosphatase-1 Inhibition by Its C-Terminal Phosphorylation
Francesca Salvi et al.
CHEMBIOCHEM (2021)
Noonan syndrome with loose anagen hair with variants in the PPP1CB gene: First familial case reported
Victoria Huckstadt et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2021)
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation
Timothy H. Tran et al.
NATURE COMMUNICATIONS (2021)
Crystal Structure Reveals the Full Ras-Raf Interface and Advances Mechanistic Understanding of Raf Activation
Trinity Cookis et al.
BIOMOLECULES (2021)
Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane
Zhenhao Fang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A
Bernhard Hoermann et al.
NATURE COMMUNICATIONS (2020)
Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme
Roman O. Fedoryshchak et al.
ELIFE (2020)
M-Ras is Muscle-Ras, Moderate-Ras, Mineral-Ras, Migration-Ras, and Many More-Ras
Takeshi Endo
EXPERIMENTAL CELL RESEARCH (2020)
M-Ras/Shoc2 signaling modulates E-cadherin turnover and cell-cell adhesion during collective cell migration
Pradeep Kota et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Clinical and functional characterization of a novel RASopathy-causing SHOC2 mutation associated with prenatal-onset hypertrophic cardiomyopathy
Marialetizia Motta et al.
HUMAN MUTATION (2019)
Severe Noonan syndrome phenotype associated with a germline Q71R MRAS variant: a recurrent substitution in RAS homologs in various cancers
Hisato Suzuki et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2019)
SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers
Greg G. Jones et al.
NATURE COMMUNICATIONS (2019)
Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes
Eunyoung Park et al.
NATURE (2019)
Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers
Rita Sulahian et al.
CELL REPORTS (2019)
COSMIC: the Catalogue Of Somatic Mutations In Cancer
John G. Tate et al.
NUCLEIC ACIDS RESEARCH (2019)
MRAS: A Close but Understudied Member of the RAS Family
Lucy C. Young et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)
Epileptic spasms in PPP1CB-associated Noonan-like syndrome: a case report with clinical and therapeutic implications
Chien-Heng Lin et al.
BMC NEUROLOGY (2018)
SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis
Lucy C. Young et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme
Ganesan Senthil Kumar et al.
SCIENCE ADVANCES (2018)
Further evidence that variants in PPP1CB cause a rasopathy similar to Noonan syndrome with loose anagen hair
Regina M. Zambrano et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2017)
Defining a Cancer Dependency Map
Aviad Tsherniak et al.
CELL (2017)
RAS Proteins and Their Regulators in Human Disease
Dhirendra K. Simanshu et al.
CELL (2017)
Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy
Erin M. Higgins et al.
JCI INSIGHT (2017)
The Recurrent PPP1CB Mutation p. Pro49Arg in an Additional Noonan- Like Syndrome Individual: Broadening the Clinical Phenotype
Debora Bertola et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2017)
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras
Tim Wang et al.
CELL (2017)
Biogenesis and activity regulation of protein phosphatase 1
Iris Verbinnen et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2017)
A Novel Rasopathy Caused by Recurrent De Novo Missense Mutations in PPP1CB Closely Resembles Noonan Syndrome with Loose Anagen Hair
Karen W. Gripp et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2016)
De novo missense variants in PPP1CB are associated with intellectual disability and congenital heart disease
Lijiang Ma et al.
HUMAN GENETICS (2016)
SHOC2 subcellular shuttling requires the KEKE motif-rich region and N-terminal leucine-rich repeat domain and impacts on ERK signalling
Marialetizia Motta et al.
HUMAN MOLECULAR GENETICS (2016)
A Novel SHOC2 Variant in Rasopathy
Vickie Hannig et al.
HUMAN MUTATION (2014)
Structural basis for protein phosphatase 1 regulation and specificity
Wolfgang Peti et al.
FEBS JOURNAL (2013)
An MRAS, SHOC2, and SCRIB Complex Coordinates ERK Pathway Activation with Polarity and Tumorigenic Growth
Lucy C. Young et al.
MOLECULAR CELL (2013)
The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme
Nichole O'Connell et al.
STRUCTURE (2012)
Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity
Aylwin C. Y. Ng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Endothelial SUR-8 Acts in an ERK-Independent Pathway During Atrioventricular Cushion Development
Jing Yi et al.
DEVELOPMENTAL DYNAMICS (2010)
Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites
Michael J. Ragusa et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
The extended PP1 toolkit: designed to create specificity
Mathieu Bollen et al.
TRENDS IN BIOCHEMICAL SCIENCES (2010)
Recognition of an intra-chain tandem 14-3-3 binding site within PKCε
Brenda Kostelecky et al.
EMBO REPORTS (2009)
Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair
Viviana Cordeddu et al.
NATURE GENETICS (2009)
Activation of protein phosphatase 1 by a small molecule designed to bind to the enzyme's regulatory site
Erin Tappan et al.
CHEMISTRY & BIOLOGY (2008)
Characterization of R-Ras3/M-Ras null mice reveals a potential role in trophic factor signaling
Nelson Nunez Rodriguez et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity
P Rodriguez-Viciana et al.
MOLECULAR CELL (2006)
Structural principles of Leucine-Rich repeat (LRR) proteins
P Enkhbayar et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2004)
Structural basis of protein phosphatase 1 regulation
M Terrak et al.
NATURE (2004)
The RAF proteins take centre stage
C Wellbrock et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate
P Rodriguez-Viciana et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
分享论文
