The effect of sex and laterality on the phenotype of primary rhegmatogenous retinal detachment

BackgroundTo assess the effect of sex and laterality on clinical features of primary rhegmatogenous retinal detachment (RRD).MethodThis study is a retrospective analysis of data prospectively collected. We extracted data from two online datasets over a 7-year period of patients older than 16 years who had undergone surgery for primary RRD. Data on baseline characteristics were analyzed to compare males versus females, and right versus left eyes.ResultsOf 8133 eyes analyzed, 4342 (53.4%) were right. The overall male predominance (63.7%) was more marked in the age range 50-69 years. Men were more commonly pseudophakic and presented more frequently with baseline posterior vitreous detachment (PVD). Female sex was significantly associated with baseline myopia, retinal holes as causative retinal break, and isolated inferior RD. Men had more frequent foveal involvement, greater RRD extent, greater numbers and larger sized retinal tears including dialysis and giant retinal tears. Regarding laterality, foveal involvement, larger retinal breaks, isolated temporal RD and temporal retinal breaks were more common in right eyes, whereas left eyes were more myopic at baseline and presented more frequently with isolated nasal RD and nasal retinal breaks.ConclusionsThis study confirmed the predominance of male sex and right laterality in RRD. Sex and laterality were associated with multiple presenting features of RRD including extent, break distribution, number, size and type, as well as RD distribution.

Automated summary

This study retrospectively analyzed data from two online datasets to assess the effect of sex and laterality on clinical features of primary RRD. The results showed a male predominance and a higher number of right eyes. Males were more commonly pseudophakic and presented with baseline posterior vitreous detachment. Females were associated with myopia, retinal holes, and isolated inferior RD. Right eyes had more foveal involvement and larger retinal tears, while left eyes were more myopic and presented with isolated nasal RD.