☆ 4.4 Review

Molecular engineering tools for the development of vaccines against infectious diseases: current status and future directions

EXPERT REVIEW OF VACCINES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Cell Biology

MHC Class II Presentation in Autoimmunity

Irina A. Ishina et al.

Summary: Antigen presentation by MHC-II is crucial for immune response and self-antigen tolerance. Certain MHC-II alleles are associated with autoimmune diseases. The process of MHC-II-mediated presentation plays a significant role in understanding the mechanisms of autoimmune diseases and the protective effect of certain MHC-II alleles.

CELLS (2023)

添加到收藏夹

Review Immunology

Recent Advances in PROTAC-Based Antiviral Strategies

Haleema Ahmad et al.

Summary: Extensive research in intracellular processes has resolved numerous mysteries in cell and molecular biology, leading to innovative technologies for treating infectious and non-infectious diseases. Viruses have caused some of the deadliest diseases, but conventional antiviral therapies have struggled to combat viral infections. The PROteolysis TArgeting Chimeras (PROTAC) technology offers a promising approach for selective protein degradation, providing new possibilities for cutting-edge antiviral treatments and vaccines.

VACCINES (2023)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Harnessing sortase A transpeptidation for advanced targeted therapeutics and vaccine engineering

Eugene M. Obeng et al.

Summary: This review briefly introduces the SrtA enzyme and its associated transpeptidation activity, and describes interesting sortase-mediated protein engineering and chemistry approaches for achieving multivalent therapeutic and antigenic responses. The review further highlights advanced applications in targeted delivery systems, multivalent therapeutics, adoptive cellular therapy, and vaccine engineering. These innovations show the potential of sortase-mediated techniques in facilitating the development of simple plug-and-play nanomedicine technologies against recalcitrant diseases and pandemics such as cancer and viral infections.

BIOTECHNOLOGY ADVANCES (2023)

添加到收藏夹

Article Health Care Sciences & Services

Safety and immunogenicity of a skin- and neuro-attenuated live vaccine for varicella: a randomized, double-blind, controlled, dose-escalation and age de-escalation phase 1 clinical trial

Zhao-Jun Mo et al.

Summary: This study evaluated the safety and immunogenicity of a skin and neuro-attenuated varicella vaccine candidate. The results showed that the vaccine candidate was well-tolerated and immunogenic in humans.

LANCET REGIONAL HEALTH-WESTERN PACIFIC (2023)

添加到收藏夹

Review Biotechnology & Applied Microbiology

PROTAC targeted protein degraders: the past is prologue

Miklos Bekes et al.

Summary: Targeted protein degradation (TPD) is a new therapeutic modality that can tackle disease-causing proteins which are difficult to target with conventional small molecules. PROTAC molecules, utilizing the ubiquitin-proteasome system to degrade target proteins, has achieved clinical proof-of-concept and attracted significant industry activity. Future directions include identifying target classes suitable for TPD, expanding the use of ubiquitin ligases for precision medicine, and extending the modality beyond oncology.

NATURE REVIEWS DRUG DISCOVERY (2022)

添加到收藏夹

Review Microbiology

Infectious disease in an era of global change

Rachel E. Baker et al.

Summary: Global changes such as climate change, urbanization, and global travel and trade have impacted the emergence and spread of infectious diseases. Recent decades have seen a wave of severe infectious disease outbreaks, including COVID-19 and Zika virus disease, which have had devastating effects worldwide.

NATURE REVIEWS MICROBIOLOGY (2022)

添加到收藏夹

Article Medicine, General & Internal

Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico

Lisa M. Dunkle et al.

Summary: The NVX-CoV2373 vaccine has shown to be safe and highly effective in preventing Covid-19, with a vaccine efficacy of 90.4% against reverse-transcriptase-polymerase-chain-reaction-confirmed cases and 100% efficacy against moderate-to-severe disease. The vaccine also demonstrated high efficacy against various variants of the virus.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Development of a skin- and neuro-attenuated live vaccine for varicella

Wei Wang et al.

Summary: The article describes the rational design of a live-attenuated varicella vaccine candidate, v7D, which is severely impaired for infection of human skin and neuronal cells but retains immunogenicity in vitro and in animal models. The vaccine shows promise as a safer alternative to current varicella vaccines with reduced risk of complications.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Design of protein-binding proteins from the target structure alone

Longxing Cao et al.

Summary: This study presents a general solution to the challenge of designing proteins that can bind to specific sites on the surface of a target protein solely based on its three-dimensional structure. Through experimental validation, the method demonstrates broad applicability and successful de novo design of binding proteins for diverse protein targets. Detailed feedback from extensive experimental data guides improvements in both the method and our understanding of protein-protein interactions.

NATURE (2022)

添加到收藏夹

Article Virology

Generation of Premature Termination Codon (PTC)-Harboring Pseudorabies Virus (PRV) via Genetic Code Expansion Technology

Tong-Yun Wang et al.

Summary: This study attempted to develop a live but replication-incompetent Pseudorabies virus (PRV) using genetic code expansion (GCE) technology. Although the premature termination codon (PTC) harboring PRV was successfully rescued, the incorporation efficacy of unnatural amino acids (UAA) was found to be extremely low. Moreover, the establishment of a stable transgenic cell line for PTC virus replication failed, with orthogonal tRNA(Pyl) identified as a limiting factor.

VIRUSES-BASEL (2022)

添加到收藏夹

Article Multidisciplinary Sciences

A live attenuated virus-based intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2

Junyu Chen et al.

Summary: Significant progress has been made in the development of intramuscular vaccines against SARS-CoV-2, but they have limitations in eliciting local immunity in the respiratory tract. To overcome this, researchers have constructed a nasal vaccine candidate using an influenza vector that contains the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. Preclinical studies have shown that this vaccine candidate provides protection against lung pathology and demonstrates cross-protection against SARS-CoV-2 variants and other influenza viruses.

SCIENCE BULLETIN (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate

Kwinten Sliepen et al.

Summary: This study describes the generation of recombinant soluble E1E2 immunogens, which are displayed on nanoparticles and induce potent neutralizing antibody responses. Furthermore, mosaic nanoparticles displaying multiple different E2E1 immunogens significantly improve neutralization.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Generation of a live attenuated influenza A vaccine by proteolysis targeting

Longlong Si et al.

Summary: The study describes the generation of a live attenuated influenza A virus vaccine using PROTAC technology to degrade viral proteins via the host cell's ubiquitin-proteasome system. The vaccine showed highly attenuated and immune responses against both homologous and heterologous virus challenges in mouse and ferret models.

NATURE BIOTECHNOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity

Coralie M. Backlund et al.

Summary: Covalent conjugation of antigens with cell-penetrating peptides enhances the potency of peptide vaccines by promoting antigen uptake by dendritic cells and accumulation in draining lymph nodes. This results in robust T cell priming and expansion.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

添加到收藏夹

Review Immunology

The use of viral vectors in vaccine development

Tatianna Travieso et al.

Summary: Vaccines are the most cost-efficient and equitable way to combat and eradicate infectious diseases. Nucleic acid vaccines, including DNA plasmid vaccines, mRNA vaccines, and recombinant viral vectors, have advantages such as inducing durable immune responses, high vaccine stability, and ease of large-scale manufacturing. In this review, we provide an overview of pre-clinical and clinical data on recombinant viral vector vaccines and discuss the advantages and limitations of different viral vector platforms.

NPJ VACCINES (2022)

添加到收藏夹

Article Multidisciplinary Sciences

A multinational Delphi consensus to end the COVID-19 public health threat

Jeffrey Lazarus et al.

Summary: Despite scientific and medical advances, political, socioeconomic, and behavioral factors continue to undermine the response to the COVID-19 pandemic. A Delphi study involving a diverse panel of experts from 112 countries and territories developed a set of recommendations across various domains to address this global threat to public health.

NATURE (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

PROTACs: past, present and future

Ke Li et al.

Summary: PROTACs are a type of molecules with novel event-driven mechanism, offering multiple advantages over traditional inhibitors, such as catalytic nature and targeted protein degradation, which may lead to improved therapeutic outcomes with reduced toxicity. However, further research and development efforts are needed to fully explore their potential.

CHEMICAL SOCIETY REVIEWS (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Challenges in the use of sortase and other peptide ligases for site-specific protein modification

Holly E. Morgan et al.

Summary: Site-specific protein modification is a widely-used biochemical tool, but there are challenges in its development. This review focuses on the engineering of peptide ligases and their substrates to address these challenges, and explores techniques to improve reaction efficiency and expand substrate scope.

CHEMICAL SOCIETY REVIEWS (2022)

添加到收藏夹

Letter Biology

Construction and characterization of UAA-controlled recombinant Zika virus by genetic code expansion

Rong-Rong Zhang et al.

SCIENCE CHINA-LIFE SCIENCES (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

CRISPR-Cas9: A Preclinical and Clinical Perspective for the Treatment of Human Diseases

Garima Sharma et al.

Summary: The revolutionary CRISPR-Cas9 technology has therapeutic potential against genetic disorders and is being tested in clinical trials for cancer treatment. In addition to therapeutic applications, it can also be used to create genetic animal models for drug discovery. However, challenges and safety concerns still need to be addressed in CRISPR-Cas9-mediated therapeutic approaches.

MOLECULAR THERAPY (2021)

添加到收藏夹

Review Chemistry, Medicinal

Proteolysis targeting chimera (PROTAC) in drug discovery paradigm: Recent progress and future challenges

Shenxin Zeng et al.

Summary: PROTAC is a novel drug discovery paradigm that targets proteins for degradation. ARV-110, an orally small molecule PROTAC designed for Androgen receptor, has entered clinical trials, marking a new avenue for PROTAC development.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

添加到收藏夹

Review Engineering, Biomedical

Next-Generation Vaccines: Nanoparticle-Mediated DNA and mRNA Delivery

William Ho et al.

Summary: Nucleic acid vaccines hold promise as an immunization method for combating pandemics, with nanoparticles being a top candidate for successful DNA/mRNA vaccine delivery due to their unique properties.

ADVANCED HEALTHCARE MATERIALS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design

Clara T. Schoeder et al.

Summary: Structure-based antibody and antigen design has advanced greatly in recent years, with improved computational methods and the availability of experimentally determined structures contributing to this progress. The Rosetta software suite has played a key role in expanding the scope of structure prediction, including docking and design applications for antibodies and antigens. These materials aim to assist novice users in applying Rosetta to their own projects for modeling antibodies and antigens.

BIOCHEMISTRY (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Engineering for an HPV 9-valent vaccine candidate using genomic constitutive over-expression and low lipopolysaccharide levels in Escherichia coli cells

Kaihang Wang et al.

Summary: By interrupting the expression of key genes involved in LPS synthesis, 7 LPS biosynthesis-defective recombinant strains were successfully constructed in E. coli to reduce endotoxin contamination. Through chromosomal integrated expression, 6 loci were identified for stable expression of HPV L1 protein, resulting in decreased endotoxin levels. In large-scale fermentation, recombinant strains with multiple copies of the expression cassette had higher overall expression and lower endotoxin levels compared to the wild-type strain.

MICROBIAL CELL FACTORIES (2021)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

AlphaFold heralds a data-driven revolution in biology and medicine

Janet M. Thornton et al.

Summary: Using artificial intelligence to predict protein structures will benefit medical research, but utilizing clinical data in a similar manner to understand human disease will provide the greatest benefit.

NATURE MEDICINE (2021)

添加到收藏夹

Editorial Material Medicine, General & Internal

Sputnik V COVID-19 vaccine candidate appears safe and effective Comment

Ian Jones et al.

LANCET (2021)

添加到收藏夹

Editorial Material Biotechnology & Applied Microbiology

Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines

S. Moein Moghimi

MOLECULAR THERAPY (2021)

添加到收藏夹

Review Immunology

COVID-19 Vaccine Hesitancy Worldwide: A Concise Systematic Review of Vaccine Acceptance Rates

Malik Sallam

Summary: COVID-19 vaccine acceptance rates are generally high worldwide, but low rates are reported in the Middle East, Russia, Africa, and certain European countries. This could pose a significant challenge in global efforts to control the pandemic. More studies are recommended to address COVID-19 vaccine hesitancy in different regions.

VACCINES (2021)

添加到收藏夹

Article Cell Biology

SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity

M. Gordon Joyce et al.

Summary: The study designed and characterized four categories of engineered nanoparticle immunogens that induced robust antibodies against SARS-CoV-2, showing effectiveness against different variants and also significant neutralizing antibody titers against SARS-CoV-1. These immunogens demonstrated high protective efficacy in animal experiments, offering new insights for vaccine development and antiviral strategies.

CELL REPORTS (2021)

添加到收藏夹

Article Infectious Diseases

Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD-based protein subunit vaccine (ZF2001) against COVID-19 in adults: two randomised, double-blind, placebo-controlled, phase 1 and 2 trials

Shilong Yang et al.

Summary: The results from Phase 1 and Phase 2 trials of the COVID-19 vaccine ZF2001 show that the vaccine is well tolerated and immunogenic, supporting the use of a 25 microgram dose in a three-dose schedule for large-scale evaluation in a Phase 3 trial.

LANCET INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses

Kevin O. Saunders et al.

Summary: This study demonstrates that immunizing macaques with nanoparticles conjugated with the receptor-binding domain of SARS-CoV-2, adjuvanted with 3M-052 and alum, can elicit cross-neutralizing antibody responses against various coronaviruses and provide protection against SARS-CoV-2. Nucleoside-modified mRNAs encoding stabilized spike proteins also induce antibody responses against different coronaviruses, suggesting potential for developing vaccines against multiple betacoronaviruses in the future.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

Prabhu S. Arunachalam et al.

Summary: This study demonstrated the effectiveness of an adjuvanted RBD-NP vaccine in inducing robust and durable neutralizing antibody responses, providing protection against SARS-CoV-2 infection, and cross-neutralizing various variants. Adjuvants such as AS03 and AS37 significantly enhanced the immunogenicity of the vaccine and have the potential to be candidates for COVID-19 vaccines.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Quadrivalent influenza nanoparticle vaccines induce broad protection

Seyhan Boyoglu-Barnum et al.

Summary: Computational design of nanoparticle immunogens can induce potent and broad antibody responses against diverse influenza viruses, including neutralizing antibody responses to vaccine-matched strains and broadly protective antibody responses to heterologous viruses. These novel vaccines have the potential to replace traditional seasonal vaccines.

NATURE (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Emerging concepts in the science of vaccine adjuvants

Bali Pulendran et al.

Summary: Adjuvants are vaccine components that enhance the immune response. Recent advances in understanding the molecular mechanisms and systems vaccinology have revitalized the science and development of novel adjuvants for use in vaccines against COVID-19 and future pandemics.

NATURE REVIEWS DRUG DISCOVERY (2021)

添加到收藏夹

Review Virology

Latest Advances of Virology Research Using CRISPR/Cas9-Based Gene-Editing Technology and Its Application to Vaccine Development

Man Teng et al.

Summary: CRISPR/Cas9-based gene-editing techniques have been widely applied in biological sciences, particularly in modifying viral genomes, to reveal gene function, virus pathogenesis, and play a crucial role in vaccine development.

VIRUSES-BASEL (2021)

添加到收藏夹

Editorial Material Microbiology

Recurring Revolutions in Virology

Lynn W. Enquist et al.

ANNUAL REVIEW OF VIROLOGY, VOL 8 (2021)

添加到收藏夹

Review Immunology

Protein-based antigen presentation platforms for nanoparticle vaccines

Brian Nguyen et al.

Summary: Modern vaccine design is moving towards minimalization, isolating antigens from pathogens to create safer vaccines. To combat global diseases, such as COVID-19, malaria, and AIDS, more effective next-generation vaccines are urgently needed. One approach to enhance the immunogenicity of vaccines involves using nanoparticle platforms to present antigens repetitively on their surface, improving antigen presenting cell uptake and B-cell activation.

NPJ VACCINES (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Lipid Nanoparticles-From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

Rumiana Tenchov et al.

Summary: Lipid nanoparticles (LNPs) have become promising vehicles in the pharmaceutical industry for delivering various therapeutics, particularly highlighted in the COVID-19 mRNA vaccines. LNPs exhibit versatility and physical stability, allowing for targeted delivery of therapeutic drugs to specific locations within the body. Liposomes, an early version of LNPs, have already been widely applied in medical practice.

ACS NANO (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Genetic Code Expansion: A Brief History and Perspective

Mia A. Shandell et al.

Summary: Biochemists have been working on fine-tuning the chemical properties of proteins to address fundamental mechanistic questions since the establishment of site-specific mutagenesis in the 1970s. Unnatural amino acid technology allows for expanding beyond the 20 naturally occurring amino acids and installing new useful chemical functions.

BIOCHEMISTRY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

CRISPR: History and perspectives to the future

Z. Kozovska et al.

Summary: This review provides an overview of the history and future prospects of the CRISPR/Cas9 method, highlighting its potential applications in genome editing and gene therapy for genetic disorders in humans, particularly cancer.

BIOMEDICINE & PHARMACOTHERAPY (2021)

添加到收藏夹

Review Immunology

Ebola virus disease: current vaccine solutions

Oyewale Tomori et al.

Summary: Ebola Virus Disease is an emerging zoonotic disease with intermittent outbreaks in Central and West African countries. Vaccine platforms have shown promise in prophylactic protection, but the process of licensing an Ebola vaccine is challenging due to sporadic outbreaks and resource constraints.

CURRENT OPINION IN IMMUNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery

Michael Segel et al.

Summary: Eukaryotic genomes contain domesticated genes from integrating viruses and mobile genetic elements, including mammalian Gag homologs and PEG10, which can be used for RNA delivery. The development of selective endogenous encapsidation for cellular delivery (SEND) using PEG10 demonstrates its potential as an efficient therapeutic delivery modality.

SCIENCE (2021)

添加到收藏夹

Article Cell Biology

Synonymous Codon Pair Recoding of the HIV-1 env Gene Affects Virus Replication Capacity

Ana Jordan-Paiz et al.

Summary: Deoptimizing synonymous codon pair bias in the HIV-1 envelope gene did not always lead to virus attenuation, while optimization of codon pair bias attenuated virus replication. The study also revealed that increasing CpG dinucleotides in the 5' end of the env gene did not always reduce the replication capacity of HIV-1.

CELLS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo

Siyuan Yu et al.

Summary: The authors present an intracellular protein delivery system that overcomes the limitations of ineffective endosomal escape and low serum tolerance associated with cell-penetrating peptide-mediated protein delivery. This system shows efficient delivery and therapeutic efficacy in a liver failure model, highlighting the potential of using multifunctional chimaeric peptides for developing cell-penetrating peptide-based protein delivery systems.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Biochemical Research Methods

Virology, epidemiology, immunology and vaccine development of SARS-CoV-2, update after nine months of pandemic

Marc Baay et al.

Summary: The International Alliance for Biological Standardization COVID-19 webinar was held to provide updates on the virology, epidemiology, immunology, and vaccine development of SARS-CoV-2 nine months after COVID-19 was declared a public health emergency of international concern. It involved a diverse group of international stakeholders from academia, regulators, funders, and industry, with a significant representation from low- and middle-income countries.

BIOLOGICALS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice

Alexander A. Cohen et al.

Summary: The study developed nanoparticles displaying the receptor binding domain (RBD) of SARS-CoV-2 and other animal coronaviruses, which induced cross-reactive antibody responses in mice. Immunization with mosaic RBD nanoparticles resulted in superior neutralization of heterologous viruses, providing a potential strategy for simultaneous protection against multiple coronaviruses.

SCIENCE (2021)

添加到收藏夹

Review Immunology

Adenovirus Vectors: Excellent Tools for Vaccine Development

Jun Chang

Summary: Adenovirus, originally used for gene therapy, has seen increased utility as a vaccine vector in recent years with higher safety and immunogenicity. It is being tested for preventing infectious diseases and as cancer vaccines, with ongoing research to overcome limitations for improved vaccine development using adenovirus vectors.

IMMUNE NETWORK (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

RTS,S/AS01 vaccine (Mosquirix?): an overview

Matthew B. Laurens

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2020)

添加到收藏夹

Article Virology

Optimization of the Codon Pair Usage of Human Respiratory Syncytial Virus Paradoxically Resulted in Reduced Viral Replication In Vivo and Reduced Immunogenicity

Cyril Le Nouen et al.

JOURNAL OF VIROLOGY (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Peptide-Based Vaccines: Current Progress and Future Challenges

Ryan J. Malonis et al.

CHEMICAL REVIEWS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Integrating gene delivery and gene-editing technologies by adenoviral vector transfer of optimized CRISPR-Cas9 components

Ignazio Maggio et al.

GENE THERAPY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Semisynthetic, self-adjuvanting vaccine development: Efficient, site-specific sortase A-mediated conjugation of Toll-like receptor 2 ligand FSL-1 to recombinant protein antigens under native conditions and application to a model group A streptococcal vaccine

Zhenghui Xu et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Editorial Material Chemistry, Medicinal

PROTAC Technology: Opportunities and Challenges

Hongying Gao et al.

ACS MEDICINAL CHEMISTRY LETTERS (2020)

添加到收藏夹

Article Cell Biology

Mechanism of Virus Attenuation by Codon Pair Deoptimization

Nicole Groenke et al.

CELL REPORTS (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice

Alec W. Freyn et al.

MOLECULAR THERAPY (2020)

添加到收藏夹

Article Immunology

Development of a new oral poliovirus vaccine for the eradication end game using codon deoptimization

Jennifer L. Konopka-Anstadt et al.

NPJ VACCINES (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Genetic-Code-Expansion Strategies for Vaccine Development

Jelle A. Fok et al.

CHEMBIOCHEM (2020)

添加到收藏夹

Review Immunology

Improving efficacy of glycoconjugate vaccines: from chemical conjugates to next generation constructs

Francesco Berti et al.

CURRENT OPINION IN IMMUNOLOGY (2020)

添加到收藏夹

Review Immunology

Improving protein glycan coupling technology (PGCT) for glycoconjugate vaccine production

Jennifer Mhairi Dow et al.

EXPERT REVIEW OF VACCINES (2020)

添加到收藏夹

Article Multidisciplinary Sciences

The pore size of mesoporous silica nanoparticles regulates their antigen delivery efficiency

Xiaoyu Hong et al.

SCIENCE ADVANCES (2020)

添加到收藏夹

Article Medicine, General & Internal

An mRNA Vaccine against SARS-CoV-2-Preliminary Report

L. A. Jackson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing

Wen-Wei Zhang et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Medicine, General & Internal

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

Edward E. Walsh et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

Longxing Cao et al.

SCIENCE (2020)

添加到收藏夹

Article Immunology

SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation

Katlyn Lederer et al.

IMMUNITY (2020)

添加到收藏夹

Article Immunology

Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses

Xiancai Ma et al.

IMMUNITY (2020)

添加到收藏夹

Review Plant Sciences

CRISPR/Cas9 Genome Editing Technology: A Valuable Tool for Understanding Plant Cell Wall Biosynthesis and Function

Yuan Zhang et al.

FRONTIERS IN PLANT SCIENCE (2020)

添加到收藏夹

Article Biology

Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions

Pranam Chatterjee et al.

COMMUNICATIONS BIOLOGY (2020)

添加到收藏夹

Article Biology

Rapid poxvirus engineering using CRISPR/Cas9 as a selection tool

Anjali Gowripalan et al.

COMMUNICATIONS BIOLOGY (2020)

添加到收藏夹

Review Immunology

Adjuvants for Coronavirus Vaccines

Zhihui Liang et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Public, Environmental & Occupational Health

COVID-19 Crisis in Jordan: Response, Scenarios, Strategies, and Recommendations

Raeda Alqutob et al.

JMIR PUBLIC HEALTH AND SURVEILLANCE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age

Barbara Muehlemann et al.

SCIENCE (2020)

添加到收藏夹

Article Infectious Diseases

The 2019-2020 Novel Coronavirus (Severe Acute Respiratory Syndrome Coronavirus 2) Pandemic: A Joint American College of Academic International Medicine-World Academic Council of Emergency Medicine Multidisciplinary COVID-19 Working Group Consensus Paper

Stanislaw P. Stawicki et al.

JOURNAL OF GLOBAL INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus

Jessica Marcandalli et al.

CELL (2019)

添加到收藏夹

Review Cell Biology

CRISPR/Cas9 technology as a potent molecular tool for gene therapy

Ansar Karimian et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

添加到收藏夹

Review Biotechnology & Applied Microbiology

mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases

Giulietta Maruggi et al.

MOLECULAR THERAPY (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Cell-Penetrating Peptides: Efficient Vectors for Vaccine Delivery

Jieru Yang et al.

CURRENT DRUG DELIVERY (2019)

添加到收藏夹

Article Public, Environmental & Occupational Health

Postlicensure Safety Surveillance of Recombinant Zoster Vaccine (Shingrix) — United States, October 2017–June 2018

Elisabeth M. Hesse et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2019)

添加到收藏夹

Review Immunology

Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity

Shuting Shi et al.

VACCINE (2019)

添加到收藏夹

Review Immunology

Recent advances in the production of recombinant glycoconjugate vaccines

Emily Kay et al.

NPJ VACCINES (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeted protein degradation: elements of PROTAC design

Stacey-Lynn Paiva et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2019)

添加到收藏夹

Article Infectious Diseases

Immunogenicity and safety of the adjuvanted recombinant zoster vaccine in adults with haematological malignancies: a phase 3, randomised, clinical trial and post-hoc efficacy analysis

Alemnew F. Dagnew et al.

LANCET INFECTIOUS DISEASES (2019)

添加到收藏夹

Review Virology

Utilization of herpesviridae as recombinant viral vectors in vaccine development against animal pathogens

Mohamed Kamel et al.

VIRUS RESEARCH (2019)

添加到收藏夹

Review Medicine, Research & Experimental

Zika Virus Vaccine Development: Progress in the Face of New Challenges

Michael S. Diamond et al.

ANNUAL REVIEW OF MEDICINE, VOL 70 (2019)

添加到收藏夹

Review Immunology

Infectious Disease Threats in the Twenty-First Century: Strengthening the Global Response

David E. Bloom et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Current Advances in Chitosan Nanoparticles Based Drug Delivery and Targeting

Unnati Garg et al.

ADVANCED PHARMACEUTICAL BULLETIN (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Shingrix: The New Adjuvanted Recombinant Herpes Zoster Vaccine

Stephanie F. James et al.

ANNALS OF PHARMACOTHERAPY (2018)

添加到收藏夹

Review Engineering, Biomedical

Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities

Ling Li et al.

BIOMATERIALS (2018)

添加到收藏夹

Review Biotechnology & Applied Microbiology

CRISPR/Cas9 genome editing technology significantly accelerated herpes simplex virus research

Dong Wang et al.

CANCER GENE THERAPY (2018)

添加到收藏夹

Review Biochemical Research Methods

Computational protein design - the next generation tool to expand synthetic biology applications

Pablo Gainza-Cirauqui et al.

CURRENT OPINION IN BIOTECHNOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Eudragit® L100-coated mannosylated chitosan nanoparticles for oral protein vaccine delivery

Bohui Xu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

添加到收藏夹

Article Virology

Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse Models

Penghui Li et al.

JOURNAL OF VIROLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

Kai Xu et al.

NATURE MEDICINE (2018)

添加到收藏夹

Review Genetics & Heredity

Detecting and Avoiding Problems When Using the Cre-Iox System

Allisa J. Song et al.

TRENDS IN GENETICS (2018)

添加到收藏夹

Article Immunology

A simple and rapid approach to develop recombinant avian herpesvirus vectored vaccines using CRISPR/Cas9 system

Na Tang et al.

VACCINE (2018)

添加到收藏夹

Review Virology

Potential Application of the CRISPR/Cas9 System against Herpesvirus Infections

Yuan-Chuan Chen et al.

VIRUSES-BASEL (2018)

添加到收藏夹

Review Multidisciplinary Sciences

The CRISPR tool kit for genome editing and beyond

Mazhar Adli

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

CRISPR-Cas9, a tool to efficiently increase the development of recombinant African swine fever viruses

Manuel V. Borca et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Post-licensure safety surveillance of zoster vaccine live (Zostavax®) in the United States, Vaccine Adverse Event Reporting System (VAERS), 2006-2015

Elaine R. Miller et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2018)

添加到收藏夹

Article Immunology

The TLR-4 agonist adjuvant, GLA-SE, improves magnitude and quality of immune responses elicited by the ID93 tuberculosis vaccine: first-in-human trial

Rhea N. Coler et al.

NPJ VACCINES (2018)

添加到收藏夹

Review Medicine, Research & Experimental

Cell penetrating peptides: A concise review with emphasis on biomedical applications

Hossein Derakhshankhah et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

Zhihai Li et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Structure of bacterial oligosaccharyltransferase PglB bound to a reactive LLO and an inhibitory peptide

Maja Napiorkowska et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Immunology

A recombinant conjugated pneumococcal vaccine that protects against murine infections with a similar efficacy to Prevnar-13

Mark Reglinski et al.

NPJ VACCINES (2018)

添加到收藏夹

Article Immunology

Efficient control of chronic LCMV infection by a CD4 T cell epitope-based heterologous prime-boost vaccination in a murine model

Ran He et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2018)

添加到收藏夹

Review Immunology

Meningococcal Vaccines: Current Status and Emerging Strategies

Pumtiwitt C. McCarthy et al.

VACCINES (2018)

添加到收藏夹

Review Immunology

Multivalent and Multipathogen Viral Vector Vaccines

Katharina B. Lauer et al.

CLINICAL AND VACCINE IMMUNOLOGY (2017)

添加到收藏夹

Review Immunology

Adjuvant system AS01: helping to overcome the challenges of modern vaccines

Arnaud M. Didierlaurent et al.

EXPERT REVIEW OF VACCINES (2017)

添加到收藏夹

Article Infectious Diseases

Safety, immunogenicity, and preliminary clinical efficacy of a vaccine against extraintestinal pathogenic Escherichia coli in women with a history of recurrent urinary tract infection: a randomised, single-blind, placebo-controlled phase 1b trial

Angela Huttner et al.

LANCET INFECTIOUS DISEASES (2017)

添加到收藏夹

Article Medicine, General & Internal

Evaluating the immunogenicity and safety of a BiondVax-developed universal influenza vaccine (Multimeric-001) either as a standalone vaccine or as a primer to H5N1 influenza vaccine Phase IIb study protocol

Eva van Doorn et al.

MEDICINE (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural Basis for the Altered PAM Recognition by Engineered CRISPR-Cpf1

Hiroshi Nishimasu et al.

MOLECULAR CELL (2017)

添加到收藏夹

Review Multidisciplinary Sciences

Expanding and reprogramming the genetic code

Jason W. Chin

NATURE (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural basis of PROTAC cooperative recognition for selective protein degradation

Morgan S. Gadd et al.

NATURE CHEMICAL BIOLOGY (2017)

添加到收藏夹

Review Biophysics

A molecular engineering toolbox for the structural biologist

Galia T. Debelouchina et al.

QUARTERLY REVIEWS OF BIOPHYSICS (2017)

添加到收藏夹

Review Immunology

The complexity and cost of vaccine manufacturing - An overview

Stanley Plotkin et al.

VACCINE (2017)

添加到收藏夹

Article Medicine, Research & Experimental

Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanoparticles and Dendritic/tumor Cells Fusion Vaccine Effectively Inhibit the Growth of Hepatocellular Carcinoma in Mice

Zixi Hu et al.

THERANOSTICS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Development of improved vaccine cell lines against rotavirus

Weilin Wu et al.

SCIENTIFIC DATA (2017)

添加到收藏夹

Review Immunology

Escherichia coli-derived virus-like particles in vaccine development

Xiaofen Huang et al.

NPJ VACCINES (2017)

添加到收藏夹

Article Oncology

Shingles (Herpes Zoster) Vaccine (Zostavax®): A Review in the Prevention of Herpes Zoster and Postherpetic Neuralgia

Gillian M. Keating

BIODRUGS (2016)

添加到收藏夹

Article Immunology

Safety and Immunogenicity of a Candidate Bioconjugate Vaccine against Shigella flexneri 2a Administered to Healthy Adults: a Single-Blind, Randomized Phase I Study

Mark S. Riddle et al.

CLINICAL AND VACCINE IMMUNOLOGY (2016)

添加到收藏夹

Article Immunology

Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs

Joao N. Duarte et al.

JOURNAL OF IMMUNOLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

Keiichiro Suzuki et al.

NATURE (2016)

添加到收藏夹

Article Biochemical Research Methods

Genetic code expansion for multiprotein complex engineering

Christine Koehler et al.

NATURE METHODS (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose

Jasdave S. Chahal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Generation of influenza A viruses as live but replication-incompetent virus vaccines

Longlong Si et al.

SCIENCE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Accurate design of megadalton-scale two-component icosahedral protein complexes

Jacob B. Bale et al.

SCIENCE (2016)

添加到收藏夹

Article Immunology

Evaluation of the attenuation, immunogenicity, and efficacy of a live virus vaccine generated by codon-pair bias de-optimization of the 2009 pandemic H1N1 influenza virus, in ferrets

Andrew J. Broadbent et al.

VACCINE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Isozygous and selectable marker-free MSTN knockout cloned pigs generated by the combined use of CRISPR/Cas9 and Cre/LoxP

Yanzhen Bi et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Multidisciplinary Sciences

A Modular Vaccine Development Platform Based on Sortase-Mediated Site-Specific Tagging of Antigens onto Virus-Like Particles

Shubing Tang et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Review Pharmacology & Pharmacy

Liposome-Based Adjuvants for Subunit Vaccines: Formulation Strategies for Subunit Antigens and Immunostimulators

Signe Tandrup Schmidt et al.

PHARMACEUTICS (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

Mucoadhesive glycol chitosan nanoparticles for intranasal delivery of hepatitis B vaccine: enhancement of mucosal and systemic immune response

Dilip Pawar et al.

DRUG DELIVERY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

A CRISPR/Cas9 and Cre/Lox system-based express vaccine development strategy against re-emerging Pseudorabies virus

Xun Liang et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Review Immunology

Recent Advances in Subunit Vaccine Carriers

Abhishek Vartak et al.

VACCINES (2016)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Coupling the CRISPR/Cas9 System with Lambda Red Recombineering Enables Simplified Chromosomal Gene Replacement in Escherichia coli

Michael E. Pyne et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2015)

添加到收藏夹

Article Biotechnology & Applied Microbiology

A simple and rapid approach to manipulate pseudorabies virus genome by CRISPR/Cas9 system

Aotian Xu et al.

BIOTECHNOLOGY LETTERS (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Secrets of a covalent interaction for biomaterials and biotechnology: SpyTag and SpyCatcher

Samuel C. Reddington et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Layer-by-Layer Assembly of Inactivated Poliovirus and N-Trimethyl Chitosan on pH-Sensitive Microneedles for Dermal Vaccination

Koen van der Maaden et al.

LANGMUIR (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Codon Bias as a Means to Fine-Tune Gene Expression

Tessa E. F. Quax et al.

MOLECULAR CELL (2015)

添加到收藏夹

Article Immunology

Safety and immunogenicity of a candidate bioconjugate vaccine against Shigella dysenteriae type 1 administered to healthy adults: A single blind, partially randomized Phase I study

Christoph F. R. Hatz et al.

VACCINE (2015)

添加到收藏夹

Article Immunology

A bioinformatics tool for epitope-based vaccine design that accounts for human ethnic diversity: Application to emerging infectious diseases

Patricio Oyarzun et al.

VACCINE (2015)

添加到收藏夹

Review Virology

Live attenuated vaccines: Historical successes and current challenges

Philip D. Minor

VIROLOGY (2015)

添加到收藏夹

Article Medicine, General & Internal

Varicella zoster virus infection

Anne A. Gershon et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Construction of a Live-Attenuated HIV-1 Vaccine through Genetic Code Expansion

Nanxi Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

SpyTag/SpyCatcher Cyclization Confers Resilience to Boiling on a Mesophilic Enzyme

Christopher Schoene et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

添加到收藏夹

Article Engineering, Biomedical

Targeted oral delivery of BmpB vaccine using porous PLGA microparticles coated with M cell homing peptide-coupled chitosan

Tao Jiang et al.

BIOMATERIALS (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization

Cyril Le Nouen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Review Immunology

Developments in Viral Vector-Based Vaccines

Takehiro Ura et al.

VACCINES (2014)

添加到收藏夹

Review Cell Biology

Metabolic Pitfalls of CNS Cre-Based Technology

Erika Harno et al.

CELL METABOLISM (2013)

添加到收藏夹

Review Chemistry, Medicinal

Modern Subunit Vaccines: Development, Components, and Research Opportunities

Peter Michael Moyle et al.

CHEMMEDCHEM (2013)

添加到收藏夹

Article Immunology

Phase II and III Clinical Studies of Diphtheria-Tetanus-Acellular Pertussis Vaccine Containing Inactivated Polio Vaccine Derived from Sabin Strains (DTaP-sIPV)

Kenji Okada et al.

JOURNAL OF INFECTIOUS DISEASES (2013)

添加到收藏夹

Review Oncology

Clinical trials of human papillomavirus vaccines and beyond

Matti Lehtinen et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Edible lipid nanoparticles: Digestion, absorption, and potential toxicity

David Julian McClements

PROGRESS IN LIPID RESEARCH (2013)

添加到收藏夹

Review Infectious Diseases

A Licensed Combined Haemophilus influenzae Type b-Serogroups C and Y Meningococcal Conjugate Vaccine

Kirsten P. Perrett et al.

INFECTIOUS DISEASES AND THERAPY (2013)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Evaluating metabolic stress and plasmid stability in plasmid DNA production by Escherichia coli

Filomena Silva et al.

BIOTECHNOLOGY ADVANCES (2012)

添加到收藏夹

Review Pharmacology & Pharmacy

Lipid nanoparticles: state of the art, new preparation methods and challenges in drug delivery

Luigi Battaglia et al.

EXPERT OPINION ON DRUG DELIVERY (2012)

添加到收藏夹

Review Immunology

Risks associated with the use of live-attenuated vaccine poliovirus strains and the strategies for control and eradication of paralytic poliomyelitis

Vaia Pliaka et al.

EXPERT REVIEW OF VACCINES (2012)

添加到收藏夹

Review Cell Biology

Designer proteins: applications of genetic code expansion in cell biology

Lloyd Davis et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin

Bijan Zakeri et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

添加到收藏夹

Article Immunology

Systematic review of regional and temporal trends in global rotavirus strain diversity in the pre rotavirus vaccine era: Insights for understanding the impact of rotavirus vaccination programs

Krisztian Banyai et al.

VACCINE (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Aluminum Vaccine Adjuvants: Are they Safe?

L. Tomljenovic et al.

CURRENT MEDICINAL CHEMISTRY (2011)

添加到收藏夹

Review Biochemistry & Molecular Biology

Sortase enzymes in Gram-positive bacteria

Thomas Spirig et al.

MOLECULAR MICROBIOLOGY (2011)

添加到收藏夹

Article Genetics & Heredity

Lambda Red Recombineering in Escherichia coli Occurs Through a Fully Single-Stranded Intermediate

J. A. Mosberg et al.

GENETICS (2010)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Live attenuated influenza virus vaccines by computer-aided rational design

Steffen Mueller et al.

NATURE BIOTECHNOLOGY (2010)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Rationalizing the development of live attenuated virus vaccines

Adam S. Lauring et al.

NATURE BIOTECHNOLOGY (2010)

添加到收藏夹

Review Pharmacology & Pharmacy

Novel cellular and molecular mechanisms of induction of immune responses by aluminum adjuvants

Vishukumar Aimanianda et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2009)

添加到收藏夹

Review Pharmacology & Pharmacy

Vaccine adjuvant systems: Enhancing the efficacy of sub-unit protein antigens

Yvonne Perrie et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)

添加到收藏夹

Article Multidisciplinary Sciences

Virus attenuation by genome-scale changes in codon pair bias

J. Robert Coleman et al.

SCIENCE (2008)

添加到收藏夹

Review Biochemical Research Methods

Replicating and non-replicating viral vectors for vaccine development

Marjorie Robert-Guroff

CURRENT OPINION IN BIOTECHNOLOGY (2007)

添加到收藏夹

Article Medicine, General & Internal

Decline in pneumonia admissions after routine childhood immunisation with pneumococcal conjugate vaccine in the USA: a time-series analysis

Carlos G. Grijalva et al.

LANCET (2007)

添加到收藏夹

Review Cell Biology

Innovation: A chemical toolkit for proteins - an expanded genetic code

Jianming Xie et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

添加到收藏夹

Article Geography

The spatial dynamics of poliomyelitis in the United States: From epidemic emergence to vaccine-induced retreat, 1910-1971

B Trevelyan et al.

ANNALS OF THE ASSOCIATION OF AMERICAN GEOGRAPHERS (2005)

添加到收藏夹

Review Chemistry, Multidisciplinary

Expanding the genetic code

L Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)

添加到收藏夹

Review Biochemistry & Molecular Biology

The biology of Gram-positive sortase enzymes

GK Paterson et al.

TRENDS IN MICROBIOLOGY (2004)

添加到收藏夹

Review Genetics & Heredity

Progress and problems with the use of viral vectors for gene therapy

CE Thomas et al.

NATURE REVIEWS GENETICS (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.