期刊
EXPERT REVIEW OF NEUROTHERAPEUTICS
卷 23, 期 2, 页码 179-186出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14737175.2023.2185138
关键词
Headache; COVID-19; post-COVID; long COVID; SARS-CoV-2; variant
This article analyzes the differences in the prevalence of headache as an onset symptom and in post-COVID headache among the different SARS-CoV-2 variants (historical strain, Alpha, Delta, and Omicron) and discusses the different pathophysiological mechanisms by which SARS-CoV-2 infection may cause headache.
IntroductionCOVID19 associated headaches are highly common and there is currently an unmet need to better understand their association with SARSCoV2 variants. Headaches are a prevalent symptom in the acute phase of COVID19 and are associated with a better prognosis and better immune response. They are also a relevant post-COVID symptom.Areas coveredThis article analyses the differences in the prevalence of headache as an onset symptom and in post-COVID headache among the different SARS-CoV-2 variants: the historical strain, Alpha, Delta and Omicron. The different pathophysiological mechanisms by which SARS-CoV-2 infection may cause headache are also discussed.Expert opinionThe presence of headache at the acute phase is a risk factor for post-COVID headache, whereas a history of primary headache does not appear to be associated with post-COVID headache. The prevalence of headache as an onset symptom appears to be variable for the different SARS-CoV-2 variants, but current data are inconclusive. However, the current evidence also suggests that headache represents a prevalent symptom in the acute and post-infection COVID-19 phase, regardless of SARS-CoV-2 variant.
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