Noncoding RNAs as a potential biomarker for the prognosis of bladder cancer: a systematic review and meta-analysis

ObjectiveThe relationship between noncoding RNAs and the prognosis of bladder cancer (BC) is still controversial. The purpose of this study is to evaluate the relationship between noncoding RNAs and prognosis by meta-analysis.MethodsComprehensive retrieval of PubMed, Embase, the Cochrane Library, the Web of Science, CNKI, and WanFang databases is related to the correlation between noncoding RNAs and the prognosis of BC. Data were extracted, and the literature quality was evaluated. STATA16.0 served for the meta-analysis.Results1. CircRNAs: High circ-ZFR expression led to poor overall survival (OS) of BC. 2. LncRNAs: Low lnc-GAS5 expression predicted poor OS of BC, high lnc-TUG1 expression predicted poor OS of BC. 3. MiRNAs: High miR-21 expression predicted poor OS of BC, high miR-222 expression led to poor OS of BC, high miR-155 expression predicted poor progression-free survival (PFS) of BC, high miR-143 expression caused poor PFS of BC, low miR-214 expression could result in poor recurrence-free survival (RFS) of BC.ConclusionsHigh circ-ZFR, lnc-TUG1, miR-222, and miR-21 expressions were correlated with poor OS of BC; high miR-155 and miR-143 expression predicted poor PFS of BC; low lnc-GAS5 expression predicted poor OS of BC; low miR-214 expression predicted poor RFS of BC.

Automated summary

This study used meta-analysis to evaluate the relationship between noncoding RNAs and the prognosis of bladder cancer. It found that high expression of circ-ZFR, lnc-TUG1, miR-222, and miR-21 were correlated with poor overall survival in bladder cancer. High expression of miR-155 and miR-143 predicted poor progression-free survival, while low expression of lnc-GAS5 predicted poor overall survival, and low expression of miR-214 predicted poor recurrence-free survival.