☆ 4.3 Review

Radiolabeled FAPI in pancreatic cancer: can it be an additional value in the management of patients?

EXPERT REVIEW OF ANTICANCER THERAPY (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

The role of [99mTc]Tc-HFAPi SPECT/CT in patients with malignancies of digestive system: first clinical experience

Xi Jia et al.

Summary: In this study, we evaluated the potential effect of [Tc-99m]Tc-HFAPi in clinical analysis for digestive system tumours and found that it has a higher sensitivity and specificity than ceCT in diagnosing distant metastases, especially in identifying liver metastases.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Tumor-to-blood ratio for assessment of fibroblast activation protein receptor density in pancreatic cancer using [68Ga]Ga-FAPI-04

Ruohua Chen et al.

Summary: In this study, the tumor-to-blood ratio (TBR) was evaluated as an effective index for assessing the uptake of [Ga-68]Ga-FAPI-04 in tumors with high FAP expression. The results showed a strong positive correlation between TBRmean and the total distribution volume (V-t) of [Ga-68]Ga-FAPI-04. TBRmean was found to better reflect FAP receptor density compared to SUVmean and SUVmax.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

First Total-Body Kinetic Modeling and Parametric Imaging of Dynamic 68Ga-FAPI-04 PET in Pancreatic and Gastric Cancer

Ruohua Chen et al.

Summary: The study aimed to explore the pharmacokinetics of 68Ga-FAPI-04 PET/CT in pancreatic cancer and gastric cancer, and compare the parametric imaging of dynamic total-body data with SUV imaging. The results showed that parametric imaging using the 2T4K model improved tumor conspicuity and image quality, which may be helpful for early diagnosis, better characterization of tumors, or evaluation of treatment response.

JOURNAL OF NUCLEAR MEDICINE (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Static and Dynamic 68Ga-FAPI PET/CT for the Detection of Malignant Transformation of Intraductal Papillary Mucinous Neoplasia of the Pancreas

Matthias Lang et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) can arise from intraductal papillary mucinous neoplasms (IPMN) with malignant transformation. However, current nonoperative differentiation methods for benign IPMN and IPMN lesions undergoing malignant transformation are unsatisfactory. This study evaluated the clinical feasibility of using Ga-68-FAPI PET for the differentiation of menacing and low-grade IPMN, and found that Ga-68-FAPI PET showed high sensitivity and specificity in distinguishing between these subtypes.

JOURNAL OF NUCLEAR MEDICINE (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Benign lesions with 68Ga-FAPI uptake: a retrospective study

Qiaoqiao Shu et al.

Summary: This study retrospectively analyzed the characteristics of benign lesions with FAPI uptake on 68Ga-FAPI PET/CT imaging, and found that in addition to malignant tumors, certain benign lesions also show FAPI uptake.

BRITISH JOURNAL OF RADIOLOGY (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Impact of Ga-68-FAPI-04 PET/CT on Staging and Therapeutic Management in Patients With Digestive System Tumors

Aleksander Kosmala et al.

Summary: The purpose of this study was to compare the impact of FAPI-directed molecular imaging with GCI on staging and therapeutic management in patients with digestive system tumors. The results showed that 68Ga-FAPI-04 PET/CT resulted in staging changes in 46.9% of patients and therapeutic modifications in 25.0% of patients. These findings may favor a more widespread adoption of FAP-directed imaging, especially in patients with HCC and PDAC.

CLINICAL NUCLEAR MEDICINE (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Positron emission tomography and computed tomography with [68Ga]Ga-fibroblast activation protein inhibitors improves tumor detection and staging in patients with pancreatic cancer

Yizhen Pang et al.

Summary: This study evaluated the diagnostic performance of [Ga-68]Ga-FAPI PET/CT in primary and metastatic pancreatic carcinoma lesions and found it to have higher sensitivity and accuracy in TNM staging compared to [F-18]FDG PET/CT.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Correlation of 68Ga-FAPi-46 PET Biodistribution with FAP Expression by Immunohistochemistry in Patients with Solid Cancers: Interim Analysis of a Prospective Translational Exploratory Study

Christine E. Mona et al.

Summary: This study demonstrates the high expression of FAP in various cancers and shows that Ga-68-FAPi-46 PET accurately reflects FAP expression. These findings are important for further research on the feasibility of using FAP as a pan-cancer imaging biomarker and a target for therapy.

JOURNAL OF NUCLEAR MEDICINE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Fibroblast Activation Protein-Specific PET/CT Imaging in Fibrotic Interstitial Lung Diseases and Lung Cancer: A Translational Exploratory Study

Manuel Roehrich et al.

Summary: This study aimed to evaluate the imaging properties of static and dynamic fibroblast activation protein (FAP) inhibitor (FAPI) PET/CT in various types of fibrosing interstitial lung diseases (fILDs) and lung cancer (LC). The results showed that Ga-68-FAPI PET/CT imaging had high uptake and good imaging characteristics for fILD and LC.

JOURNAL OF NUCLEAR MEDICINE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Feasibility, Biodistribution, and Preliminary Dosimetry in Peptide-Targeted Radionuclide Therapy of Diverse Adenocarcinomas Using 177Lu-FAP-2286: First-in-Humans Results

Richard P. Baum et al.

Summary: The study on Lu-177-FAP-2286 for peptide-targeted radionuclide therapy (PTRT) showed promising results in advanced adenocarcinoma patients, with a relatively good tolerability and acceptable side effects. Further prospective clinical studies are needed to confirm its efficacy.

JOURNAL OF NUCLEAR MEDICINE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Physiological tracer distribution and benign lesion incidental uptake of Al18F-NOTA-FAPI-04 on PET/CT imaging

Ying Kou et al.

Summary: This study systematically investigates the physiological distribution and benign lesion incidental uptake of F-18-FAPI in cancer patients and establishes the normal uptake range in relevant organs and lesions.

NUCLEAR MEDICINE COMMUNICATIONS (2022)

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Article Oncology

Associations between Normal Organs and Tumor Burden in Patients Imaged with Fibroblast Activation Protein Inhibitor-Directed Positron Emission Tomography

Aleksander Kosmala et al.

Summary: This study investigates the relationship between radiotracer uptake in normal organs and tumor burden in patients with solid tumors. The results show no significant correlation between normal organs and tumor burden, except for a trend in the myocardium.

CANCERS (2022)

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Article Oncology

Safety and Efficacy of 90Y-FAPI-46 Radioligand Therapy in Patients with Advanced Sarcoma and Other Cancer Entities

Wolfgang P. Fendler et al.

Summary: This study reports the efficacy and safety of 90Y-labeled FAPI-46 in patients with advanced sarcoma, pancreatic cancer, and other cancers. The results show disease control in approximately 38% of patients, with a prolonged overall survival associated with disease control. However, there were adverse events observed, with thrombocytopenia and anemia being the most common.

CLINICAL CANCER RESEARCH (2022)

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Article Oncology

Subclass Analysis of Malignant, Inflammatory and Degenerative Pathologies Based on Multiple Timepoint FAPI-PET Acquisitions Using FAPI-02, FAPI-46 and FAPI-74

Frederik M. Glatting et al.

Summary: FAPI-PET is a promising imaging technique for various pathologies, showing differential uptake behavior over time in different lesions and providing additional imaging information. The differences in uptake kinetics of malignant and benign pathologies contribute to the interpretation of FAPI-positive lesions.

CANCERS (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Usefulness of [68Ga]Ga-DOTA-FAPI-04 PET/CT in patients presenting with inconclusive [18F]FDG PET/CT findings

Haojun Chen et al.

Summary: This prospective study evaluated the potential usefulness of [Ga-68]Ga-DOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT) in oncological evaluation of patients with inconclusive [F-18]FDG PET/CT findings. The study found that [Ga-68]Ga-DOTA-FAPI-04 may have a complementary role in discriminating mass lesions on conventional imaging, locating unknown primary sites in biopsy-proven metastatic malignancy, modifying tumor staging, and detecting suspected disease recurrence. However, caution should be exercised when interpreting [Ga-68]Ga-DOTA-FAPI-04 PET/CT images in tumors complicated with inflammation.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

FAPI-74 PET/CT Using Either 18F-AlF or Cold-Kit 68Ga Labeling: Biodistribution, Radiation Dosimetry, and Tumor Delineation in Lung Cancer Patients

Frederik L. Giesel et al.

Summary: F-18-FAPI-74 shows good physiological distribution and tumor uptake in PET scans of lung cancer patients. The effective dose radiation burden of F-18-FAPI-74 is lower than that of F-18-FDG and other F-18 tracers, while Ga-68-FAPI-74 is comparable to other Ga-68 ligands.

JOURNAL OF NUCLEAR MEDICINE (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Fibroblast Activation Protein-Targeted PET/CT with 68Ga-FAPI for Imaging IgG4-Related Disease: Comparison to 18F-FDG PET/CT

Yaping Luo et al.

Summary: Ga-68-FAPI shows promising potential as an imaging agent for assessing IgG4-RD, with higher detection rates in involved organs compared to F-18-FDG PET/CT, especially in the pancreas, bile duct/liver, and lacrimal gland. This suggests its potential utility in improving the evaluation of IgG4-related disease.

JOURNAL OF NUCLEAR MEDICINE (2021)

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Editorial Material Radiology, Nuclear Medicine & Medical Imaging

[68Ga]Ga-DOTA-FAPI-04 PET/CT imaging in a case of prostate cancer with shoulder arthritis

Tingting Xu et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Impact of 68Ga-FAPI PET/CT Imaging on the Therapeutic Management of Primary and Recurrent Pancreatic Ductal Adenocarcinomas

Manuel Roehrich et al.

Summary: The use of Ga-68-FAPI PET/CT imaging in PDAC patients led to significant changes in TNM staging and impacted the management of some patients.

JOURNAL OF NUCLEAR MEDICINE (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Active uptake of 68Ga-FAPI in Crohn's disease but not in ulcerative colitis

Yaping Luo et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Biodistribution, pharmacokinetics, dosimetry of [68Ga]Ga-DOTA.SA.FAPi, and the head-to-head comparison with [18F]F-FDG PET/CT in patients with various cancers

Sanjana Ballal et al.

Summary: The study evaluated the biodistribution, pharmacokinetics, and dosimetry of a new FAPi tracer [Ga-68]Ga-DOTA.SA.FAPi and compared it with the standard-of-care radiotracer [F-18]F-FDG in cancer patients. Results showed physiological uptake in organs such as liver, kidneys, and pancreas, with higher SULpeak and avg values in patients with H&N cancers.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Non-malignant findings of focal 68Ga-FAPI-04 uptake in pancreas

Xiao Zhang et al.

Summary: Although Ga-68-FAPI-04 shows great potential for oncological diagnosis, focal uptake of Ga-68-FAPI-04 may occur in benign pancreatic lesions and should be carefully evaluated. Fortunately, Ga-68-FAPI-04 PET/MR, when combined with MR imaging, may potentially help avoid misdiagnosis of certain pancreatic lesions.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Radiolabeled fibroblast activation protein inhibitor (FAPI) pet in oncology: has the time come for18F-fluorodeoxyglucose to think to a well-deserved retirement?

Priscilla Guglielmo et al.

CLINICAL AND TRANSLATIONAL IMAGING (2021)

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Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Inflammatory Arthritis Induced by Anti-Programmed Death-1 Shown in 68Ga-FAPI PET/CT in a Patient With Esophageal Carcinoma

Yaping Luo et al.

Summary: A 30-year-old woman with esophageal squamous cell carcinoma developed polyarthritis during neoadjuvant immunochemotherapy. PET/CT scans showed complete response of the tumor, while the polyarthritis was considered to be inflammatory arthritis induced by anti-PD1 therapy.

CLINICAL NUCLEAR MEDICINE (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Value of [68Ga]Ga-FAPI-04 imaging in the diagnosis of renal fibrosis

Yue Zhou et al.

Summary: This study evaluated the diagnostic performance of a novel PET radiotracer for renal fibrosis detection, demonstrating its ability to quickly demonstrate bilateral kidney conditions and provide important information for disease progression, diagnosis, and treatment plan development.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Review Radiology, Nuclear Medicine & Medical Imaging

The role of FDG PET/CT or PET/MRI in assessing response to neoadjuvant therapy for patients with borderline or resectable pancreatic cancer: a systematic literature review

Laura Evangelista et al.

Summary: FDG PET/CT or PET/MRI can be useful for predicting and assessing the response to CRT in patients with resectable or borderline PDAC. Higher baseline SUVs are associated with better treatment response and overall survival, while high SUVs post neoadjuvant therapy are correlated with poor prognosis.

ANNALS OF NUCLEAR MEDICINE (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Head-to-head intra-individual comparison of biodistribution and tumor uptake of 68Ga-FAPI and 18F-FDG PET/CT in cancer patients

Frederik L. Giesel et al.

Summary: The study aimed to compare Ga-68-FAPI and F-18-FDG in organ biodistribution and tumor uptake in PET/CT, showing that Ga-68-FAPI has lower uptake in most normal tissues compared to F-18-FDG, resulting in significantly higher TBRs at some sites for Ga-68-FAPI.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Review Oncology

Neoadjuvant Treatment Strategies in Resectable Pancreatic Cancer

Aurelien Lambert et al.

Summary: Only 10-20% of patients with resectable pancreatic adenocarcinoma have potentially resectable disease. After surgical extirpation of tumors, up to 80% of patients will develop cancer recurrence, and adjuvant chemotherapy is the best strategy to improve overall survival. Neoadjuvant treatment shows some promising results but still requires further investigation to be validated.

CANCERS (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Radiation Dosimetry and Biodistribution of 68Ga-FAPI-46 PET Imaging in Cancer Patients

Catherine Meyer et al.

JOURNAL OF NUCLEAR MEDICINE (2020)

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Review Cell Biology

Synovial fibroblasts and articular tissue remodelling: Role and mechanisms

Thomas Pap et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F] FDG PET/CT for the diagnosis of primary and metastatic lesions in patients with various types of cancer

Haojun Chen et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Design and Development of 99mTc-Labeled FAPI Tracers for SPECT Imaging and 188Re Therapy

Thomas Lindner et al.

JOURNAL OF NUCLEAR MEDICINE (2020)

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Article Rheumatology

Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging

Christian Schmidkonz et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Review Multidisciplinary Sciences

Fibrosis: from mechanisms to medicines

Neil C. Henderson et al.

NATURE (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

68Ga-FAPI PET/CT: Tracer Uptake in 28 Different Kinds of Cancer

Clemens Kratochwil et al.

JOURNAL OF NUCLEAR MEDICINE (2019)

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Review Radiology, Nuclear Medicine & Medical Imaging

The diagnostic performance of CT versus FDG PET-CT for the detection of recurrent pancreatic cancer: a systematic review and meta-analysis

Lois A. Daamen et al.

EUROPEAN JOURNAL OF RADIOLOGY (2018)

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Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Fibroblast-Activating Protein: Targeting the Roots of the Tumor Microenvironment

Jens T. Siveke

JOURNAL OF NUCLEAR MEDICINE (2018)

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Review Medicine, Research & Experimental

The impact of cancer-associated fibroblasts on major hallmarks of pancreatic cancer

Qiqing Sun et al.

THERANOSTICS (2018)

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Review Oncology

The role of stromal cancer-associated fibroblasts in pancreatic cancer

Dagny von Ahrens et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

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Article Gastroenterology & Hepatology

Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas

Masao Tanaka et al.

PANCREATOLOGY (2017)

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Article Oncology

Cancer Statistics, 2016

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2016)

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Review Biochemical Research Methods

Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy

Elizabeth J. Hamson et al.

PROTEOMICS CLINICAL APPLICATIONS (2014)

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Article Gastroenterology & Hepatology

Imaging diagnosis of pancreatic cancer: A state-of-the-art review

Eun Sun Lee et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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Review Gastroenterology & Hepatology

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Federico Coccolini et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2013)

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Article Medicine, General & Internal

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

David Moher et al.

ANNALS OF INTERNAL MEDICINE (2009)

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Article Orthopedics

Single-stage multilevel soft-tissue surgery in the lower limbs with spastic cerebral palsy: Experience from a rehabilitation unit

Anupam Gupta et al.

INDIAN JOURNAL OF ORTHOPAEDICS (2008)

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