Next-generation viral nanoparticles for targeted delivery of therapeutics: Fundamentals, methods, biomedical applications, and challenges

Article Chemistry, Multidisciplinary

Delivery of MicroRNAs by plant virus-based nanoparticles to functionally alter the osteogenic differentiation of human mesenchymal stem cells

Fei Xue et al.

Summary: A novel plant virus gene delivery system based on CCMV was constructed to enhance the stability and cellular membrane penetration efficiency of miR-26a, promoting osteogenic differentiation of mesenchymal stem cells.

CHINESE CHEMICAL LETTERS (2023)

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Review Biochemistry & Molecular Biology

Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy?

Longfei Deng et al.

Summary: Gene therapy shows potential in curing cancer by editing tumor cells' deleterious genes, but inefficient delivery of genetic material into specific tumor sites limits its efficacy in cancer gene therapy. Lentiviral vectors (LVs) can be modified through pseudotyping to selectively kill tumor cells, as they have altered tropism and cell-type specificity in transduction. LVs' ability to efficiently deliver genes in vivo makes them attractive tools in future cancer gene therapy. This review summarizes the current status of pseudotyping LVs and their applications in basic anti-cancer studies across various malignancies, as well as discusses the opportunities of translating pseudotyped LVs into clinical use in cancer therapy.

GENES & DISEASES (2023)

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Article Biotechnology & Applied Microbiology

Manufacturing a chimpanzee adenovirus-vectored SARS-CoV-2 vaccine to meet global needs

Carina C. D. Joe et al.

Summary: In response to the COVID-19 pandemic, we have developed an effective vaccine based on novel manufacturing technologies, allowing for large-scale production and distributed manufacturing to ensure international supply security and cost-effectiveness.

BIOTECHNOLOGY AND BIOENGINEERING (2022)

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Article Biochemistry & Molecular Biology

Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins

Samagya Banskota et al.

Summary: We have developed and applied engineered DNA-free virus-like particles (eVLPs) for efficient delivery of gene editing tools, achieving high levels of base editing. By overcoming the limitations of cargo packaging, release, and localization, the fourth-generation eVLPs demonstrated efficient base editing in mouse and human cells. In addition, the off-target effects of eVLPs were significantly reduced compared to other delivery methods such as AAV or plasmid.

CELL (2022)

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Article Medicine, General & Internal

Final efficacy analysis, interim safety analysis, and immunogenicity of a single dose of recombinant novel coronavirus vaccine (adenovirus type 5 vector) in adults 18 years and older: an international, multicentre, randomised, double-blinded, placebo-controlled phase 3 trial

Scott A. Halperin et al.

Summary: The Ad5-nCoV vaccine showed a 57.5% efficacy against PCR-confirmed COVID-19 infection at least 28 days post-vaccination and demonstrated safety in healthy adults aged 18 years and older during the phase 3 trial.

LANCET (2022)

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Review Pharmacology & Pharmacy

Current approaches of nanomedicines in the market and various stage of clinical translation

Xiaoting Shan et al.

Summary: Compared with traditional drug therapy, nanomedicines have shown intriguing biological features that enhance therapeutic efficiency and reduce toxicity. This review provides an overview of currently launched or in-clinical-trial nanomedicines, highlighting the diversified trends in carrier types, applied indications, and mechanisms of action. Additionally, the review presents the applications of nanomedicines in the prevention, diagnosis, and treatment of various diseases, such as cancer, infections, blood disorders, cardiovascular diseases, immuno-associated diseases, and nervous system diseases. The article also offers considerations and perspectives for the research and development of nanomedicines to facilitate their translation into clinical practice.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Chemistry, Medicinal

Targeted Enzymatic VLP-Nanoreactors with β-Glucocerebrosidase Activity as Potential Enzyme Replacement Therapy for Gaucher's Disease

Kanchan Chauhan et al.

Summary: Encapsulated enzyme nanoreactors showed significant GCase catalytic activity and enhanced stability under physiological conditions. Targeting to macrophages was achieved through mannose receptor functionalization, suggesting potential for enzyme replacement therapy in Gaucher's disease.

CHEMMEDCHEM (2022)

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Review Immunology

Viral vector vaccines

Naina McCann et al.

Summary: Viral vector vaccines, utilizing recombinant viruses to deliver immunogens, have shown significant impact and efficacy in the response to the SARS-CoV-2 pandemic. Adenoviral vector vaccines, in particular, have demonstrated strong immune responses and hold promise in the fight against infectious diseases.

CURRENT OPINION IN IMMUNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Toxicologic Concerns with Current Medical Nanoparticles

Tsai-Mu Cheng et al.

Summary: Nanotechnology, as a scientific advance in technology, has different effects on cell physiological responses due to changes in the shape of nanoparticles. The toxicity of nanomaterials is influenced by characteristics such as composition, surface chemistry, surface charge, and shape. This review explores the impact of NPs on nanomedicine and the mechanisms of cytotoxicity induced by different types of nanomaterials.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biology

Process- and product-related impurities in the ChAdOx1 nCov-19 vaccine

Lea Krutzke et al.

Summary: ChAdOx1 nCoV-19 vaccine contains higher than expected levels of host cell proteins (HCPs) and free viral proteins, while Ad26.COV2.S vaccine has low amounts of HCPs. The purification procedures of ChAdOx1 nCoV-19 vaccine should be modified to remove protein impurities, and standard quality assays for protein manufacturing need to be adapted for vectored vaccines.

ELIFE (2022)

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Review Biotechnology & Applied Microbiology

Nanoparticle classification, physicochemical properties, characterization, and applications: a comprehensive review for biologists

Nadeem Joudeh et al.

Summary: Interest in nanoparticles has grown rapidly in recent decades due to their unique physical and chemical properties. This review provides a comprehensive overview of nanoparticles, including their characterization methods and applications. It also highlights the environmentally friendly alternative of biologically synthesizing nanoparticles.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Pharmacology & Pharmacy

Monoclonal antibody as a targeting mediator for nanoparticle targeted delivery system for lung cancer

Nasrul Wathoni et al.

Summary: Lung cancer, the second most common type of cancer, has the highest mortality rate. Nanoparticle technology is being developed for lung cancer therapies, but specific ligands are needed to enhance drug delivery precision. Monoclonal antibodies can actively target nanoparticles to cancer cells, but they have drawbacks. Formulating antibodies in nanoparticles can minimize these drawbacks and enhance drug targeting.

DRUG DELIVERY (2022)

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Review Virology

Virus-like Particles as Nanocarriers for Intracellular Delivery of Biomolecules and Compounds

Junyao He et al.

Summary: Virus-like particles (VLPs) are assembled nanostructures made from viral proteins, and they have been widely used for vaccine development and as nanocarriers for cargo delivery. VLPs have good cell penetrating property, making them ideal for intracellular delivery of biomolecules and drugs. This article summarizes the current advances and applications of VLPs as delivery vectors, including the delivery of different types of biomolecules and drugs, and highlights the strategies for cargo packaging. The production and applications of VLPs are briefly reviewed, along with a discussion on future challenges in this field.

VIRUSES-BASEL (2022)

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Review Materials Science, Biomaterials

Transport of nanomedicines across the blood-brain barrier: Challenges and opportunities for imaging and therapy

Sara Lopes van den Broek et al.

Summary: The blood-brain barrier (BBB) prevents toxins and foreign bodies from entering the brain, hindering the development of nanomedicines for brain diseases. Various strategies, such as transcytosis and BBB disruption techniques, have been explored to overcome this barrier. Recent research on focused ultrasound-based BBB opening shows promising results for the delivery of nanomedicines into the brain.

BIOMATERIALS ADVANCES (2022)

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Article Chemistry, Multidisciplinary

Transport of Molecular Cargo by Interaction with Virus-Like Particle RNA

Soumen Das et al.

Summary: This study identified a simple general method for non-covalent packaging and subsequent release of functional molecules inside nucleoprotein nanocages, independent of modifications to the capsid protein.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Review Medicine, Research & Experimental

The viral capsid as novel nanomaterials for drug delivery

Alaa A. A. Aljabali et al.

Summary: Viruses self-assemble into particles with potential applications in drug delivery and molecular imaging, making them valuable tools in biotechnology.

FUTURE SCIENCE OA (2021)

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Article Biochemical Research Methods

Induced Disassembly of a Virus-like Particle under Physiological Conditions for Venom Peptide Delivery

M. Patrick Kelly et al.

Summary: The study introduces a mechanism based on ROMP for controlled VLP disassembly, by covalently conjugating ROMP substrate with surface-exposed lysine residues of VLP, inducing ROMP with AquaMet to release target substances. This strategy does not rely on specific VLP structure or morphology, applicable for potential pharmacological applications.

BIOCONJUGATE CHEMISTRY (2021)

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Review Pharmacology & Pharmacy

Antibody-mediated drug delivery

Fatma Betul Arslan et al.

Summary: Passive and active targeted nanoparticulate delivery systems have the potential to compensate for the shortcomings of conventional therapy. Active targeted delivery systems have not yet been clinically used, but efforts are ongoing to formulate them successfully. Monoclonal antibodies and their fragments as targeting ligands are the main focus of this review.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Biotechnology & Applied Microbiology

Self-assembled Viral Nanoparticles as Targeted Anticancer Vehicles

Yuanzheng Wu et al.

Summary: Viral nanoparticles are versatile building blocks and supra-molecular templates in nanotechnology, offering advantages such as biocompatibility, biodegradability, water solubility, and high uptake capability. They have been utilized for genetic and chemical manipulation, targeted drug delivery, and encapsulation of various payloads for diagnosis or therapeutic intervention.

BIOTECHNOLOGY AND BIOPROCESS ENGINEERING (2021)

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Article Clinical Neurology

Onasemnogene abeparvovec gene therapy for symptomatic infantile-onset spinal muscular atrophy type 1 (STR1VE-EU): an open-label, single-arm, multicentre, phase 3 trial

Eugenio Mercuri et al.

Summary: The STR1VE-EU study evaluated the safety and efficacy of onasemnogene abeparvovec gene replacement therapy in infants with spinal muscular atrophy type 1, showing effectiveness in symptomatic patients and a favorable benefit-risk profile for this patient population. Further long-term safety studies are needed.

LANCET NEUROLOGY (2021)

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Review Chemistry, Multidisciplinary

Endocytosis of abiotic nanomaterials and nanobiovectors: Inhibition of membrane trafficking

Pooyan Makvandi et al.

Summary: This article discusses the exposure of humans to nanobiovectors and nanomaterials, as well as the interactions between cell membranes and these nanostructures, providing insights for scientists to design better biomedical nanomaterials. It also highlights the importance of understanding viral infections and their treatment.

NANO TODAY (2021)

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Article Biochemistry & Molecular Biology

Hepatitis B Virus-Like Particle: Targeted Delivery of Plasmid Expressing Short Hairpin RNA for Silencing the Bcl-2 Gene in Cervical Cancer Cells

Made Angga Akwiditya et al.

Summary: Gene therapy using tHBcAg VLP as a carrier for shRNA targeting anti-apoptotic Bcl-2 has shown promising results in downregulating Bcl-2 expression in cancer cells. The encapsidated plasmid conjugated with folic acid demonstrated targeted delivery and significant reduction in cell viability, indicating the potential of this approach for gene silencing in cancer therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, General & Internal

Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine

Ann R. Falsey et al.

Summary: The clinical trial in the United States, Chile, and Peru showed that the AZD1222 vaccine was both safe and effective in preventing symptomatic and severe Covid-19 cases, with an overall estimated efficacy of 74% and a higher efficacy of 83.5% in participants 65 years of age or older. The high vaccine efficacy was consistent across various demographic subgroups, and antibodies increased significantly after each dose.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Biotechnology & Applied Microbiology

Recombinant turnip yellow mosaic virus coat protein as a potential nanocarrier

F. H. Tan et al.

Summary: The study successfully displayed a 10-residue peptide on the surface of TYMVcHis(6) VLPs, showing high stability under different pH and temperature conditions, and the ability to reassemble into VLPs after chemical denaturation.

JOURNAL OF APPLIED MICROBIOLOGY (2021)

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Article Medicine, General & Internal

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

Denis Y. Logunov et al.

Summary: The Gam-COVID-Vac vaccine showed 91.6% efficacy against COVID-19 in the phase 3 trial, with good safety and tolerability in a large cohort of participants.

LANCET (2021)

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Article Multidisciplinary Sciences

Bacteriophage uptake by mammalian cell layers represents a potential sink that may impact phage therapy

Marion C. Bichet et al.

Summary: It has been found that bacteriophages have tropisms beyond their bacterial hosts and can adhere to mammalian tissues before being internalized through processes like macropinocytosis. Understanding these interactions may have significant implications on immune responses, phage pharmacokinetics, and the efficacy of phage therapy.

ISCIENCE (2021)

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Article Nanoscience & Nanotechnology

Encapsulation of NIR-II AIEgens in Virus-like Particles for Bioimaging

Xuehong Min et al.

Summary: The development of organic nanoparticles with NIR-II fluorescence properties, encapsulated in virus-like particles as templates, enables high-quality in vivo imaging and image-guided surgeries, representing a new type of AIE nanoprobes for biomedical imaging.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Biochemical Research Methods

Dual Site-Selective Presentation of Functional Handles on Protein-Engineered Cowpea Chlorotic Mottle Virus-Like Particles

Daan F. M. Vervoort et al.

Summary: Protein cages show promise as carrier systems in nanomedicine due to their defined size and biodegradability, but require stability and surface modifications for drug delivery. By combining protein engineering and bio-orthogonal chemistry, successful introduction of functional peptides and fluorescent dyes into CCMV capsids for cell uptake studies was achieved.

BIOCONJUGATE CHEMISTRY (2021)

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Review Biotechnology & Applied Microbiology

Plant Virus Nanoparticles for Anti-cancer Therapy

Srividhya Venkataraman et al.

Summary: Plant virus nanoparticles (VNPs) are cost-effective, safe, and efficacious as treatments, showing potential as epitope carriers for vaccines and agents in cancer immunotherapy. Their highly immunogenic nature and ability to promote antigen presentation make them promising platforms for inducing robust immune responses.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Infectious Diseases

Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial

Keith J. Chappell et al.

Summary: The study evaluated the safety and immunogenicity of a novel COVID-19 vaccine, showing promising results in both aspects. Adverse reactions were minimal, and the vaccine elicited antigen-specific responses regardless of the dosage.

LANCET INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency

D. B. Kohn et al.

Summary: Gene therapy for ADA deficiency in 50 patients in the United States and the United Kingdom resulted in high overall survival and event-free survival rates, sustained metabolic correction, and functional immune reconstitution. No adverse events such as replication-competent virus, abnormal proliferations, autoimmunity, or graft-versus-host disease were observed.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Integrase-derived peptides together with CD24-targeted lentiviral particles inhibit the growth of CD24 expressing cancer cells

Shiran Shapira et al.

Summary: A novel targeted cancer therapeutic platform based on lentiviral integrase stimulated by integrase-derived peptides specifically delivered to cancer cells via CD24 antigen-antibody targeting is proposed. The platform leads to apoptosis in tumor cells by inducing genomic instability, presenting a potentially effective and safe approach for selective cancer cell eradication.

ONCOGENE (2021)

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Article Virology

The pharmacology of plant virus nanoparticles

Christian Isalomboto Nkanga et al.

Summary: The application of nanoparticles in medicine has greatly advanced, with plant virus-based nanoparticles being studied for drug delivery and imaging. While there are many reports on engineering and manufacturing aspects of VNPs, research on the nanotoxicity of this new platform nanotechnology is relatively scarce.

VIROLOGY (2021)

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Article Multidisciplinary Sciences

Molecular exclusion limits for diffusion across a porous capsid

Ekaterina Selivanovitch et al.

Summary: The study investigates the size and charge limitations of molecules entering virus-like particles, finding that negatively charged substrates diffuse across more readily compared to neutral ones. The research provides important insights into molecular transport across physical barriers.

NATURE COMMUNICATIONS (2021)

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Article Biochemistry & Molecular Biology

Single-Point Mutations in Qβ Virus-like Particles Change Binding to Cells

Marisa L. Martino et al.

Summary: Virus-like particles (VLPs) use lysine residues for nonspecific interactions with cells; chemical modification of these residues can reduce binding. Functional mutations of lysine residues on the VLP surface can alter cellular binding specificity, providing potential for targeted delivery applications.

BIOMACROMOLECULES (2021)

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Article Cell & Tissue Engineering

Anti-tumor effects of vascular endothelial growth factor/vascular endothelial growth factor receptor binding domain-modified chimeric antigen receptor T cells

Haiyan Xing et al.

Summary: The study presented a novel chimeric antigen receptor (CAR) T cell targeting both VEGFR-2 and VEGFR-3, which demonstrated significant anti-tumor activity by inhibiting the growth, infiltration, and metastasis of breast cancer cells.

CYTOTHERAPY (2021)

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Article Chemistry, Multidisciplinary

PhotothermalPhage: A Virus-Based Photothermal Therapeutic Agent

Arezoo Shahrivarkevishahi et al.

Summary: A new generation immunophotothermal agent is developed by utilizing a chemically modified VLP called bacteriophage Q beta to adjuvant photothermal ablation. This system, named PhotothermalPhage, combines the benefits of near-infrared absorbing croconium dyes with the structure of VLPs to generate more heat and act as an immunoadjuvant, leading to effective tumor suppression and increased survival time.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Oncology

Overcoming PD-1 Blockade Resistance with CpG-A Toll-Like Receptor 9 Agonist Vidutolimod in Patients with Metastatic Melanoma

Antoni Ribas et al.

Summary: In patients with advanced melanoma, combining intratumoral TLR9 agonist vidutolimod with pembrolizumab showed promising clinical activity and manageable safety profile, indicating potential to overcome resistance to PD-1 blockade through IFN response induction.

CANCER DISCOVERY (2021)

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Article Cell Biology

Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering

Jennifer R. Hamilton et al.

Summary: A new strategy has been developed in this study, which uses engineered lentiviral particles to introduce Cas9 RNPs and a CAR transgene into human T cells ex vivo, allowing targeting of specific cell types within a mixed population. This approach provides a method for genetic modification of immune cells without the need for electroporation.

CELL REPORTS (2021)

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Review Biology

Recent advances in lentiviral vectors for gene therapy

Xiaoyu Wang et al.

Summary: Lentiviral vectors, derived from HIV, have been widely used in research and clinical trials for modifying eukaryotic cell genes, showing promising results in treating diseases such as leukemia, beta-thalassemia, and immunodeficiency disorders. Their safety and efficiency make them a valuable tool for human gene therapy.

SCIENCE CHINA-LIFE SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Viral vector platforms within the gene therapy landscape

Jote T. Bulcha et al.

Summary: The field of gene therapy has made significant progress in combating human diseases and providing hope to patients and families with limited treatment options, but it has also faced setbacks. Viral-based vectors have played a crucial role in developing powerful drug platforms, but challenges still limit their full potential.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Biochemistry & Molecular Biology

Combination of cabazitaxel and p53 gene therapy abolishes prostate carcinoma tumor growth

Rodrigo Esaki Tamura et al.

GENE THERAPY (2020)

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Review Biotechnology & Applied Microbiology

The approved gene therapy drugs worldwide: from 1998 to 2019

Cui-Cui Ma et al.

BIOTECHNOLOGY ADVANCES (2020)

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Article Nanoscience & Nanotechnology

Brome mosaic virus-like particles as siRNA nanocarriers for biomedical purposes

Alfredo Nunez-Rivera et al.

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2020)

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Article Biochemical Research Methods

Supramolecular Encapsulation of Small-Ultrared Fluorescent Proteins in Virus-Like Nanoparticles for Noninvasive In Vivo Imaging Agents

Fabian C. Herbert et al.

BIOCONJUGATE CHEMISTRY (2020)

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Article Medicine, General & Internal

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial

Feng-Cai Zhu et al.

LANCET (2020)

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Review Pharmacology & Pharmacy

Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications

Young Hun Chung et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Oncology

Development of a VLP-Based Vaccine Displaying an xCT Extracellular Domain for the Treatment of Metastatic Breast Cancer

Valeria Rolih et al.

CANCERS (2020)

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Article Medicine, Research & Experimental

Strategies for Precise Engineering and Conjugation of Antibody Targeted-nanoparticles for Cancer Therapy

Yuan-yuan Guo et al.

CURRENT MEDICAL SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Modular Hepatitis B Virus-like Particle Platform for Biosensing and Drug Delivery

Emily J. Hartzell et al.

ACS NANO (2020)

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Article Biochemical Research Methods

Doxorubicin-Loaded Physalis Mottle Virus Particles Function as a pH-Responsive Prodrug Enabling Cancer Therapy

He Hu et al.

BIOTECHNOLOGY JOURNAL (2020)

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Article Multidisciplinary Sciences

Targeted delivery of 5-fluorouracil-1-acetic acid (5-FA) to cancer cells overexpressing epithelial growth factor receptor (EGFR) using virus-like nanoparticles

Bee Koon Gan et al.

SCIENTIFIC REPORTS (2020)

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Article Virology

Plant Viruses and Bacteriophage-Based Reagents for Diagnosis and Therapy

Sourabh Shukla et al.

ANNUAL REVIEW OF VIROLOGY, VOL 7, 2020 (2020)

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Article Biochemical Research Methods

Synthetic Virus-like Particles for Glutathione Biosynthesis

Yang Wang et al.

ACS SYNTHETIC BIOLOGY (2020)

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Article Medicine, Research & Experimental

Cisplatin Prodrug-Loaded Nanoparticles Based on Physalis Mottle Virus for Cancer Therapy

He Hu et al.

MOLECULAR PHARMACEUTICS (2020)

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Article Immunology

Rapid Response Subunit Vaccine Design in the Absence of Structural Information

Danushka K. Wijesundara et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Tuning the catalytic properties of P22 nanoreactors through compositional control

Jhanvi Sharma et al.

NANOSCALE (2020)

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Review Chemistry, Multidisciplinary

Nanoparticles: Properties, applications and toxicities

Ibrahim Khan et al.

ARABIAN JOURNAL OF CHEMISTRY (2019)

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Article Biophysics

Enhanced anti-tumor efficacy and reduced cardiotoxicity of doxorubicin delivered in a novel plant virus nanoparticle

Effat Alemzadeh et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Biochemistry & Molecular Biology

Delivering SaCas9 mRNA by lentivirus-like bionanoparticles for transient expression and efficient genome editing

Baisong Lu et al.

NUCLEIC ACIDS RESEARCH (2019)

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Review Plant Sciences

Small, Smaller, Nano: New Applications for Potato Virus X in Nanotechnology

Juliane Roeder et al.

FRONTIERS IN PLANT SCIENCE (2019)

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Article Oncology

A Phase I-II Study Using Rexin-G Tumor-Targeted Retrovector Encoding a Dominant-Negative Cyclin G1 Inhibitor for Advanced Pancreatic Cancer

Sant P. Chawla et al.

MOLECULAR THERAPY-ONCOLYTICS (2019)

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Article Nanoscience & Nanotechnology

Physalis Mottle Virus-like Nanoparticles for Targeted Cancer Imaging

He Hu et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Review Pharmacology & Pharmacy

Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine

Nathan D. Donahue et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Review Pharmacology & Pharmacy

Cowpea mosaic virus nanoparticles for cancer imaging and therapy

Perrin H. Beatty et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Article Pharmacology & Pharmacy

Onasemnogene Abeparvovec: First Global Approval

Sheridan M. Hoy

DRUGS (2019)

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Article Biotechnology & Applied Microbiology

Development of target-tunable P22 VLP-based delivery nanoplatforms using bacterial superglue

Hansol Kim et al.

BIOTECHNOLOGY AND BIOENGINEERING (2019)

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Article Immunology

An Influenza A Vaccine Based on the Extracellular Domain of Matrix 2 Protein Protects BALB/C Mice Against H1N1 and H3N2

Hui Kian Ong et al.

VACCINES (2019)

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Article Biochemical Research Methods

Theranostic Quercetin Nanoparticle for Treatment of Hepatic Fibrosis

Qiang Zhang et al.

BIOCONJUGATE CHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

Shielding of Hepatitis B Virus-Like Nanoparticle with Poly(2-Ethyl-2-Oxazoline)

See Yee Fam et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Chemistry, Multidisciplinary

Pharmaceutical Development of AAV-Based Gene Therapy Products for the Eye

Gerard A. Rodrigues et al.

PHARMACEUTICAL RESEARCH (2019)

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Article Multidisciplinary Sciences

Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins

Philippe E. Mangeot et al.

NATURE COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

Engineering the PP7 Virus Capsid as a Peptide Display Platform

Liangjun Zhao et al.

ACS NANO (2019)

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Article Pharmacology & Pharmacy

A Viral Nanoparticle Cancer Vaccine Delays Tumor Progression and Prolongs Survival in a HER2+ Tumor Mouse Model

Sourabh Shukla et al.

ADVANCED THERAPEUTICS (2019)

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Article Multidisciplinary Sciences

Thermally-responsive Virus-like Particle for Targeted Delivery of Cancer Drug

Qiu Xian Thong et al.

SCIENTIFIC REPORTS (2019)

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Article Nanoscience & Nanotechnology

Hybrid Assembly toward Enhanced Thermal Stability of Virus-like Particles and Antibacterial Activity of Polyoxometalates

Ding-Yi Fu et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Medicine, Research & Experimental

Lung cancer targeted therapy: Folate and transferrin dual targeted, glutathione responsive nanocarriers for the delivery of cisplatin

Sheng Tan et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Biotechnology & Applied Microbiology

The First Approved Gene Therapy Product for Cancer Ad-p53 (Gendicine): 12 Years in the Clinic

Wei-Wei Zhang et al.

HUMAN GENE THERAPY (2018)

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Article Materials Science, Multidisciplinary

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Functional RNAs: combined assembly and packaging in VLPs

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Phototoxic aptamers selectively enter and kill epithelial cancer cells

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Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis

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