4.6 Review

Drug loaded implantable devices to treat cardiovascular disease

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Summary: In this study, an electrospun core-shell nanofiber loaded with ROS scavenger TEMPOL and VSMC inhibitor RAPA was developed to improve the biocompatibility of drug-eluting stent coatings. The membrane selectively inhibited VSMC proliferation while protecting endothelial cells, and showed superior antioxidant, anti-inflammatory, and anti-thrombotic effects.

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Jaryl Chen Koon Ng et al.

Summary: Drug delivery systems in cardiovascular applications include drug-eluting stents and drug-coated balloons to ensure effective treatment. Besides antiproliferative drugs, growth factors, genetic materials, hormones, and signaling molecules are also used. Nanoencapsulation techniques are developed for targeted drug delivery. This review discusses drug delivery and coating mechanisms in current drug-eluting stents and drug-coated balloons, as well as innovations in drug-eluting stent technologies and drug encapsulation in nanocarriers for vascular diseases.

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Summary: Localized drug delivery from drug-eluting stents can provide therapeutic efficacy with minimal systemic toxicity. The researchers in this study developed a micro- to nanoscale network assembly composed of copper ion and epigallocatechin gallate (EGCG), which can release rapamycin and promote endothelial cell growth. The coated stents exhibited long-term antithrombotic efficacy and attenuated the negative impact of rapamycin on endothelial cells.

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Sadia Hassan et al.

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