Neural control of coronary artery blood flow by non-adrenergic and non-cholinergic mechanisms

Review Cardiac & Cardiovascular Systems

Coronary blood flow in heart failure: cause, consequence and bystander

Gerd Heusch

Summary: Heart failure is a clinical syndrome characterized by inadequate cardiac output to maintain perfusion and normal bodily functions. It can be caused by reduced coronary blood flow in both ischemic and non-ischemic forms.

BASIC RESEARCH IN CARDIOLOGY (2022)

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Article Peripheral Vascular Disease

Aortic Body Chemoreceptors Regulate Coronary Blood Flow in Conscious Control and Hypertensive Sheep

Dylan Pen et al.

Summary: This study found that activation of the aortic bodies can increase coronary blood flow, mediated by a cholinergic mechanism. In hypertensive animals, activation of the aortic bodies also increased coronary blood flow without significant difference compared to the normotensive group. However, the coronary vasodilation in hypertensive animals was affected by propranolol. These results reveal the important role of the aortic bodies in modulating coronary blood flow and the alteration of their effector mechanism in hypertension.

HYPERTENSION (2022)

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Article Cardiac & Cardiovascular Systems

Elevated circulating level of P2X7 receptor is related to severity of coronary artery stenosis and prognosis of acute myocardial infarction

Xiang-Xiang Shi et al.

Summary: This study found that circulating levels of P2X7R were elevated in AMI patients and closely associated with the severity of coronary artery stenosis and prognosis of AMI. Additionally, higher P2X7R mRNA expression was associated with a higher rate of MACE within 360 days after AMI.

CARDIOLOGY JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Coronary microvascular dysfunction is associated with exertional haemodynamic abnormalities in patients with heart failure with preserved ejection fraction

Ali Ahmad et al.

Summary: This study found that coronary microvascular function is inversely associated with filling pressures, particularly during exercise. Both types of coronary microvascular dysfunction are associated with higher filling pressures at peak exercise.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

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Review Physiology

Mechanobiology of Microvascular Function and Structure in Health and Disease: Focus on the Coronary Circulation

Maarten M. Brandt et al.

Summary: The article discusses the role of coronary microvasculature in regulating myocardial perfusion and oxygen demand, outlining both short-term and chronic flow regulation mechanisms. It explores the molecular mechanisms and cardiovascular risk factors influencing microvascular function and structure alterations.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Physiology

Regulation of Coronary Blood Flow by the Carotid Body Chemoreceptors in Ovine Heart Failure

Mridula Pachen et al.

Summary: The results of the experiment indicate that in an ovine model of heart failure, carotid body-mediated increases in coronary blood flow (CoBF) and vascular conductance (CVC) are more pronounced compared to control animals. This increase in CoBF is mediated by an increase in cardiac sympathetic nerve activity in the control group, but not in the heart failure group.

FRONTIERS IN PHYSIOLOGY (2021)

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Review Biochemistry & Molecular Biology