Trained immunity and epigenetic memory in long-term self-renewing hematopoietic cells

Review Immunology

BCG vaccination induces cross-protective immunity against pathogenic microorganisms

Jorge A. Soto et al.

Summary: BCG vaccine is used to prevent tuberculosis infection and has the ability to enhance immune response to other vaccines and promote nonspecific immunomodulatory effects through epigenetic reprogramming and metabolic shifts.

TRENDS IN IMMUNOLOGY (2022)

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Article Cell Biology

BCG vaccination provides protection against IAV but not SARS-CoV-2

Eva Kaufmann et al.

Summary: A study found that while BCG vaccine can provide protection against influenza virus, it is ineffective against SARS-CoV-2. This may be due to the unique pulmonary vasculature damage caused by SARS-CoV-2, which facilitates the virus to spread to other organs, including the central site for BCG-induced trained immunity. In addition, individuals vaccinated with BCG show a strong immune response to influenza virus but minimal response to SARS-CoV-2.

CELL REPORTS (2022)

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Editorial Material Immunology

Culture amplified macrophages reassume identity and function in vivo

Michael H. Sieweke

Summary: Alveolar macrophages (AMs), which are resident macrophages of the lung, can be expanded ex vivo but may undergo epigenetic and transcriptional changes. However, when transplanted into mice lungs, culture-expanded AMs regain their in vivo identity and function.

NATURE IMMUNOLOGY (2022)

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Article Immunology

Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo

Sethuraman Subramanian et al.

Summary: Sieweke and colleagues demonstrate that alveolar macrophages maintain their core gene expression program even after long-term culture and regain their full transcriptional and epigenetic identity upon transplantation into the lung. This study shows that culture adaptations observed in ex vivo expanded alveolar macrophages are reversible and do not compromise their cellular identity in vivo. These findings provide new insights into the mechanisms of alveolar macrophages and highlight their therapeutic potential.

NATURE IMMUNOLOGY (2022)

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Review Immunology

Targeting immunometabolism in host defence against Mycobacterium tuberculosis

Frederick J. Sheedy et al.

Summary: This article discusses the reasons why tuberculosis remains pandemic and the importance of host defense strategies, focusing mainly on the metabolic demands of immune cells involved in host resistance and disease tolerance. The study suggests that targeting key players in immune cellular metabolism may provide a novel opportunity for treatments at different stages of TB disease.

IMMUNOLOGY (2021)

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Article Immunology

Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche

Wakako Kuribayashi et al.

Summary: As hematopoietic stem cells (HSCs) age, they exhibit reduced regenerative capacity and myeloid-biased differentiation. The aging of the HSC niche also contributes to these functional alterations. However, transplanting aged HSCs into young mice revealed that the young niche was insufficient to fully rejuvenate HSC functions, emphasizing the importance of age-associated cell-intrinsic defects in HSC aging.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Editorial Material Immunology

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Maziar Divangahi et al.

Summary: Researchers are working towards establishing a set of experimental standards to reach consensus on defining trained immunity, which will help advance research in this field.

NATURE IMMUNOLOGY (2021)

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Article Cell & Tissue Engineering

Establishment, maintenance, and recall of inflammatory memory

Samantha B. Larsen et al.

Summary: The research explains how cells establish, maintain, and recall inflammatory memory, revealing the collaboration between factors like FOS and JUN, and their crucial role in re-recruiting and activating genes under diverse secondary challenges.

CELL STEM CELL (2021)

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Review Immunology

Inflammation as a regulator of hematopoietic stem cell function in disease, and clonal selection

Francisco Caiado et al.

Summary: Inflammation is a defense response to infection or tissue damage involving activation and consumption of immune cells. Hematopoietic stem cells are influenced by inflammatory cues, replacing mature immune cells as needed. Lifelong inflammatory exposure contributes to HSC aging and the selection of premalignant HSC clones.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Immunology

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions

Theodore T. Ho et al.

Summary: The study indicated that despite the rejuvenating effects of young blood on aged tissues, the aged blood system and old hematopoietic stem cells (HSCs) are not significantly affected by exposure to young blood. Old HSC function is not improved by exercise, calorie restriction, or exposure to young niches, while young HSCs are resistant to systemic proaging conditions.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Multidisciplinary Sciences

Prevention of tuberculosis in macaques after intravenous BCG immunization

Patricia A. Darrah et al.

NATURE (2020)

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Article Immunology

EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential

Marta Derecka et al.

NATURE IMMUNOLOGY (2020)

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Article Cell & Tissue Engineering

C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells

Berengere de Laval et al.

CELL STEM CELL (2020)

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Article Cell Biology

β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1

Simone J. C. F. M. Moorlag et al.

CELL REPORTS (2020)

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Article Microbiology

BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

Branko Cirovic et al.

CELL HOST & MICROBE (2020)

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Article Immunology

Influenza Infection Induces Alveolar Macrophage Dysfunction and Thereby Enables Noninvasive Streptococcus pneumoniae to Cause Deadly Pneumonia

Atul K. Verma et al.

JOURNAL OF IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity

Nargis Khan et al.

CELL (2020)

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Article Cell & Tissue Engineering

TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration

Masayuki Yamashita et al.

CELL STEM CELL (2019)

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Article Biology

Isolation and Long-term Cultivation of Mouse Alveolar Macrophages

Clara Jana-Lui Busch et al.

BIO-PROTOCOL (2019)

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Article Biochemistry & Molecular Biology

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

Anette Christ et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Ioannis Mitroulis et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

Eva Kaufmann et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

Yushi Yao et al.

CELL (2018)

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Article Immunology

The fate and lifespan of human monocyte subsets in steady state and systemic inflammation

Amit A. Patel et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Correction Biochemistry & Molecular Biology

Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells (vol 167, pg 1310, 2016)

Vionnie W. C. Yu et al.

CELL (2017)

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Article Biochemistry & Molecular Biology

β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance

Boris Novakovic et al.

CELL (2016)

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Article Cell Biology

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

Eric M. Pietras et al.

NATURE CELL BIOLOGY (2016)

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Article Multidisciplinary Sciences

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells

Erinn L. Soucie et al.

SCIENCE (2016)

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Article Immunology

The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory

Keisuke Yoshida et al.

NATURE IMMUNOLOGY (2015)

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Article Immunology

Protection by BCG Vaccine Against Tuberculosis: A Systematic Review of Randomized Controlled Trials

Punam Mangtani et al.

CLINICAL INFECTIOUS DISEASES (2014)

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Article Hematology

Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling

Stefanie Bugl et al.

BLOOD (2013)

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Article Cell & Tissue Engineering

Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging

Isabel Beerman et al.

CELL STEM CELL (2013)

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Article Immunology

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

Simon Yona et al.

IMMUNITY (2013)

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Article Multidisciplinary Sciences

M-CSF instructs myeloid lineage fate in single haematopoietic stem cells

Noushine Mossadegh-Keller et al.

NATURE (2013)

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Review Multidisciplinary Sciences

Beyond Stem Cells: Self-Renewal of Differentiated Macrophages

Michael H. Sieweke et al.

SCIENCE (2013)

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Editorial Material Multidisciplinary Sciences

Saving lives by training innate immunity with bacille Calmette-Guerin vaccine

Peter Aaby et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Multidisciplinary Sciences

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Christian Schulz et al.

SCIENCE (2012)

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Article Microbiology

Trained Immunity: A Memory for Innate Host Defense

Mihai G. Netea et al.

CELL HOST & MICROBE (2011)

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Article Multidisciplinary Sciences

MafB/c-Maf Deficiency Enables Self-Renewal of Differentiated Functional Macrophages

Athar Aziz et al.

SCIENCE (2009)

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Article Immunology

Macrophage receptors implicated in the adaptive form of innate immunity

D. M. E. Bowdish et al.

MICROBES AND INFECTION (2007)

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Article Multidisciplinary Sciences

Gene-specific control of inflammation by TLR-induced chromatin modifications

Simmie L. Foster et al.

NATURE (2007)

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Article Immunology

Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment

Yoshinori Nagai et al.

IMMUNITY (2006)

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Article Multidisciplinary Sciences

Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells

CJ Luckey et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Review Immunology

TLR signaling pathways

K Takeda et al.

SEMINARS IN IMMUNOLOGY (2004)

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Article Hematology

Interaction of human hematopoietic stem cells with bacterial pathogens

A Kolb-Mäurer et al.

BLOOD (2002)

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Trained immunity and epigenetic memory in long-term self-renewing hematopoietic cells

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