Spatial transcriptomics in human skin research

Spatial transcriptomics is a revolutionary technique that enables researchers to characterise tissue architecture and localisation of gene expression. A plethora of technologies that map gene expression are currently being developed, aiming to facilitate spatially resolved, high-dimensional assessment of gene transcription in the context of human skin research. Knowing which gene is expressed by which cell and in which location within skin, facilitates understanding of skin function and dysfunction in both health and disease. In this review, we summarise the available spatial transcriptomic methods and we describe their application to a broad spectrum of dermatological diseases.

Automated summary

Spatial transcriptomics is a revolutionary technique that helps researchers understand tissue architecture and gene expression localization. Various technologies are being developed to map gene expression, aiming to facilitate the assessment of gene transcription in human skin research. Knowing the gene expression of different cells in different skin locations enhances understanding of skin function and dysfunction in health and disease.