4.4 Article

GDF15 plays a critical role in insulin secretion in INS-1 cells and human pancreatic islets

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Pharmacology & Pharmacy

GDF15: a potential therapeutic target for type 1 diabetes

Soumyadeep Sarkar et al.

Summary: This paper discusses the potential role of GDF15 in preventing insulitis and protecting pancreatic beta cells against cellular stress. Although GDF15 shows promise as a potential intervention, further development is needed, and challenges such as anorexia and short half-life need to be addressed.

EXPERT OPINION ON THERAPEUTIC TARGETS (2022)

Article Cell Biology

Growth differentiation factor-15 prevents glucotoxicity and connexin-36 downregulation in pancreatic beta-cells

Mohamed Asrih et al.

Summary: GDF15 plays a role in preventing glucotoxicity-mediated altered glucose-stimulated insulin secretion and connexin-36 downregulation. Inhibition of endogenous GDF15 reduces glucose-stimulated insulin secretion in normal conditions while exacerbating glucolipotoxicity-reduced cell survival. This indicates that endogenous GDF15 is necessary for cell survival but not glucose-stimulated insulin secretion in the context of glucolipotoxicity.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2022)

Article Cell Biology

NAG-1/GDF15 protects against streptozotocin-induced type 1 diabetes by inhibiting apoptosis, preserving beta-cell function, and suppressing inflammation in pancreatic islets

Ying Wang et al.

Summary: The study found that NAG-1/GDF15 transgenic mice are resistant to diabetogenesis induced by multiple low-dose streptozotocin. Overexpression of NAG-1/GDF15 significantly reduced the incidence of diabetes and improved glucose intolerance and insulin resistance.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2022)

Review Biochemistry & Molecular Biology

The Effect of Oxidative Stress and Antioxidant Therapies on Pancreatic β-cell Dysfunction: Results from in Vitro and in Vivo Studies

Ioanna A. Anastasiou et al.

Summary: Oxidative stress is implicated in many diseases, particularly in pancreatic beta-cell dysfunction and apoptosis associated with diabetes. Antioxidants, especially natural extracts, have shown protective effects on pancreatic beta-cells in vitro and in vivo, while evidence for the antioxidant effects of antidiabetic drugs is limited.

CURRENT MEDICINAL CHEMISTRY (2021)

Review Cell Biology

Mechanisms controlling pancreatic islet cell function in insulin secretion

Jonathan E. Campbell et al.

Summary: Insulin secretion from pancreatic beta-cells is tightly regulated by various factors such as glucose, amino acids, fatty acids, metabolites, etc., which is crucial for understanding pancreatic dysfunction in diabetes. The complementary actions of insulin and glucagon in mammals tightly regulate metabolic homeostasis, and the dysregulation of these hormones can lead to various pathologies, notably type 2 diabetes.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Cell Biology

Heme Oxygenase-1 (HMOX-1) and inhibitor of differentiation proteins (ID1, ID3) are key response mechanisms against iron-overload in pancreatic β-cells

Mawieh Hamad et al.

Summary: Iron overload promotes the generation of reactive oxygen species, leading to oxidative stress in pancreatic beta-cells. Through RNA-sequencing and functional experiments, it was found that HMOX1, ID1, and ID3 play key roles in the protective response against iron overload-induced stress in beta-cells. The differential expression of genes in response to iron overload includes TGF-beta, regulating stem cells, ferroptosis, and HIF-1 signaling pathways.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2021)

Review Biochemistry & Molecular Biology

The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes

Natsuki Eguchi et al.

Summary: Diabetes is a chronic metabolic disorder characterized by inappropriately elevated glucose levels due to impaired pancreatic beta cell function and insulin resistance. Studies have shown that endoplasmic reticulum stress, mitochondrial dysfunction, and oxidative stress play central roles in promoting beta cell dysfunction, with oxidative stress particularly important as beta cells exhibit lower antioxidative capacity. Efforts are being made to understand and counteract the effects of oxidative stress on beta cell health and survival.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

Copine 3 CPNE3 is a novel regulator for insulin secretion and glucose uptake in pancreatic β-cells

Waseem El-Huneidi et al.

Summary: The study revealed that CPNE3 plays a crucial role in maintaining normal beta-cell function, with its silencing impairing insulin secretion and beta-cell function. This finding suggests CPNE3 as a potential new target for future management of type 2 diabetes therapy.

SCIENTIFIC REPORTS (2021)

Article Multidisciplinary Sciences

GDF15 mediates the effects of metformin on body weight and energy balance

Anthony P. Coll et al.

NATURE (2020)

Article Endocrinology & Metabolism

GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS

Vicky Wang-Wei Tsai et al.

INTERNATIONAL JOURNAL OF OBESITY (2019)

Article Cell Biology

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

Satish Patel et al.

CELL METABOLISM (2019)

Review Physiology

GDF15 and Growth Control

Paul J. Emmerson et al.

FRONTIERS IN PHYSIOLOGY (2018)

Article Cell Biology

Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys

Yumei Xiong et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Medicine, Research & Experimental

GDF15 is a heart-derived hormone that regulates body growth

Ting Wang et al.

EMBO MOLECULAR MEDICINE (2017)

Review Endocrinology & Metabolism

GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective

Ramu Adela et al.

JOURNAL OF DIABETES RESEARCH (2015)

Letter Endocrinology & Metabolism

GDF15 Is a Novel Biomarker for Impaired Fasting Glucose (Diabetes Metab J 2014; 38: 472-9)

Bo Kyung Koo

DIABETES & METABOLISM JOURNAL (2015)

Article Endocrinology & Metabolism

NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism

K. Chrysovergis et al.

INTERNATIONAL JOURNAL OF OBESITY (2014)

Review Biochemistry & Molecular Biology

A Fresh View of Glycolysis and Glucokinase Regulation: History and Current Status

Sigurd Lenzen

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Multidisciplinary Sciences

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

Joao Fadista et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Physiology

Regulation of pancreatic beta-cell mass

L Bouwens et al.

PHYSIOLOGICAL REVIEWS (2005)

Article Biochemistry & Molecular Biology

MafA is a key regulator of glucose-stimulated insulin secretion

C Zhang et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion

M Brissova et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)