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Article
Medicine, General & Internal
Meghan Lyman et al.
Summary: The number of Candida auris cases in the United States has been increasing each year, with a significant rise in 2021. Echinocandin-resistant cases have also increased in 2021, which is concerning as echinocandins are the first-line therapy for C auris infections. These findings highlight the need for improved detection and infection control practices for preventing the spread of C auris.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Camilla Sticchi et al.
Summary: Candida auris was first detected in Italy in July 2019, with one additional case reported in January 2020. Nine months later, a large number of cases were reported in northern Italy. A total of 361 cases were detected between July 2019 and December 2022 in various regions of Italy, with 146 deaths. The majority of cases were considered to be colonization, and only one had a history of travel abroad. Most isolates showed resistance to fluconazole.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Nicholas Geremia et al.
Summary: Candida auris is a newly emerged fungal pathogen with high mortality rates, persistent candidemia, inconsistencies in susceptibility testing, and misidentification issues. Multidrug-resistant and pandrug-resistant strains are increasing. Outbreaks caused by C. auris have been reported in hospitals across Europe, and sporadic cases have been detected in all European countries. Enhanced control measures are necessary due to the difficulty in controlling the survival and colonization abilities of C. auris.
Article
Microbiology
Dipti Sharma et al.
Summary: Echinocandins are frontline antifungal agents for the management of invasive infections due to multidrug resistant Candida auris. This study evaluated echinocandin resistance in 199 C. auris isolates from 30 centers across India, identifying FKS1 mutations as key factors. The study found that FKS1 genotype is a more accurate predictor of in vivo response than MIC, and other factors such as chitin content can also influence the response to echinocandins.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Anke Kohlenberg et al.
Summary: The number of cases and outbreaks of Candida auris infection or carriage, as well as the number of countries reporting these cases, increased in the European Union and European Economic Area between 2020 and 2021. Adequate laboratory capacity and surveillance are necessary for early detection and rapid implementation of control measures.
Article
Infectious Diseases
Federica Briano et al.
Summary: Candida auris (C. auris) is an emerging nosocomial pathogen that has shown a sharp rise in colonization and infection cases during the COVID-19 pandemic. This study found a high cumulative incidence of C. auris candidemia in colonized patients, with multisite colonization being an independent risk factor for candidemia development.
INFECTIOUS DISEASES AND THERAPY
(2022)
Review
Microbiology
Jeffrey M. Rybak et al.
Summary: Fungal infections cause significant health problems, and the resistance to antifungal drugs poses a threat to public health. Some pathogenic fungi display resistance to major antifungal drugs. This article provides an overview of the current knowledge on the molecular and genetic basis for antifungal resistance in this fungal pathogen.
CURRENT OPINION IN MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Jose F. Munoz et al.
Summary: Candida auris has four major clades with different infection characteristics and drug resistance profiles. While Clade II primarily causes ear infections and is susceptible to antifungal drugs, Clades I, III, and IV are responsible for ongoing outbreaks of invasive and multidrug-resistant infections.
Article
Microbiology
Vincenzo Di Pilato et al.
Summary: The study identified the recent introduction of MDR Candida auris in an Italian hospital, likely facilitated by the COVID-19 pandemic. All isolates belonged to the South Asian clade, with most transmission associated with a ward converted to a dedicated ICU during the pandemic.
Article
Microbiology
Rory M. Welsh et al.
Summary: By establishing an empirical outbreak benchmark dataset consisting of 23 Candida auris genomes, comparisons of genomic analyses can be validated and communication among surveillance networks can be facilitated. This benchmark dataset demonstrates a polyclonal phylogeny structure, showcasing the diversity of Candida auris genomes.
Article
Infectious Diseases
Ivan M. Pchelin et al.
Article
Immunology
Chayanika Biswas et al.
OPEN FORUM INFECTIOUS DISEASES
(2020)
Article
Infectious Diseases
Francesca Crea et al.
Review
Microbiology
Farid Chaabane et al.
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Infectious Diseases
Nancy A. Chow et al.
LANCET INFECTIOUS DISEASES
(2018)
