Brain correlates of subjective cognitive complaints in COVID-19 survivors: A multimodal magnetic resonance imaging study

Editorial Material Multidisciplinary Sciences

Nervous system consequences of COVID-19

Serena Spudich et al.

Summary: Understanding the pathophysiological mechanisms behind neurological symptoms is crucial.

SCIENCE (2022)

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Review Pharmacology & Pharmacy

Neurological manifestations of long-COVID syndrome: a narrative review

Maria-Ioanna Stefanou et al.

Summary: Accumulating evidence suggests a high prevalence of prolonged neurological symptoms among COVID-19 survivors. 'Long-COVID' is conceptualized as a multi-organ disorder with a wide range of clinical manifestations. Neuroinflammatory and oxidative stress processes are thought to be involved in the development of neurological sequelae. Collaborative research initiatives are urgently needed to expedite the development of preventive and therapeutic strategies for these symptoms.

THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2022)

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Review Immunology

Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis

Felicia Ceban et al.

Summary: Post-COVID-19 syndrome, characterized by persistent symptoms after resolution of acute infection, is associated with significant fatigue and cognitive impairment. This study aimed to quantify the proportion of individuals experiencing fatigue and cognitive impairment 12 or more weeks after COVID-19 diagnosis, and to explore the inflammatory and functional consequences of post-COVID-19 syndrome. The results showed that a significant proportion of individuals continue to experience fatigue and cognitive impairment even after 12 or more weeks of COVID-19 diagnosis. Additionally, some individuals showed elevated levels of inflammatory markers and significant functional impairment.

BRAIN BEHAVIOR AND IMMUNITY (2022)

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Meeting Abstract Psychiatry

Subjective cognitive complaints and neuropsychological performance at six months post COVID-19

S. Andersson et al.

JOURNAL OF PSYCHOSOMATIC RESEARCH (2022)

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Article Multidisciplinary Sciences

SARS-CoV-2 is associated with changes in brain structure in UK Biobank

Gwenaelle Douaud et al.

Summary: Through long-term observation of participants' MRI images, it was found that COVID-19 infection is associated with abnormal brain changes, including a reduction in gray matter thickness in the orbitofrontal cortex and parahippocampal gyrus, greater changes in markers of tissue damage in regions functionally connected to the primary olfactory cortex, and a greater reduction in global brain size. Infected individuals also showed significant cognitive decline.

NATURE (2022)

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Article Medicine, General & Internal

Chemotherapy-Related Cognitive Impairment in Patients with Breast Cancer Based on Functional Assessment and NIRS Analysis

Noelia Duran-Gomez et al.

Summary: This study aims to investigate the impact of chemotherapy-related cognitive impairment (CRCI) in breast cancer patients during chemotherapy treatment and its relationship with changes in cerebral activity during a verbal fluency task. The results show that chemotherapy causes cognitive impairments in patients with breast cancer, affecting their cognitive function.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Neurosciences

Changes in the Intranetwork and Internetwork Connectivity of the Default Mode Network and Olfactory Network in Patients with COVID-19 and Olfactory Dysfunction

Hui Zhang et al.

Summary: OD is a common symptom in COVID-19 patients, and many neurological manifestations have been reported. This study found increased intranetwork connectivity in the default mode network and stronger internetwork connectivity between the olfactory network and the default mode network in COVID-19 patients with OD. However, no significant difference was found in the intranetwork connectivity within the olfactory network. These results suggest that resting-state fMRI is an important tool for evaluating neurosensory dysfunction in COVID-19 patients.

BRAIN SCIENCES (2022)

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Article Clinical Neurology

Widespread white matter oedema in subacute COVID-19 patients with neurological symptoms

Alexander Rau et al.

Summary: Using diffusion microstructure imaging, researchers found widespread interstitial oedema in subacute COVID-19 inpatients, which is associated with cognitive impairment and changes in brain metabolism.

BRAIN (2022)

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Article Clinical Neurology

Lower levels of glutathione in the anterior cingulate cortex associate with depressive symptoms and white matter hyperintensities in COVID-19 survivors

Sara Poletti et al.

Summary: The study suggests associations between depressive symptoms, cerebral white matter alterations, and brain glutathione (GSH) levels in COVID-19 survivors, with systemic inflammation playing a role in GSH concentration.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2022)

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Article Psychiatry

Neuropsychological, Medical, and Psychiatric Findings After Recovery From Acute COVID-19: A Cross-sectional Study

Stephen J. Ferrando et al.

Summary: This study describes the neuropsychological, medical, psychiatric, and functional correlates of cognitive complaints experienced after recovery from acute COVID-19 infection. The results suggest the existence of extremely low neuropsychological test performance, which is associated with worse acute COVID-19 symptoms, depression, medical comorbidities, functional complaints, and subjective cognitive complaints. Exploratory correlations with proinflammatory cytokines support further research into inflammatory mechanisms and viable treatments.

JOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY (2022)

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Article Clinical Neurology

Functional connectivity underlying cognitive and psychiatric symptoms in post-COVID-19 syndrome: is anosognosia a key determinant?

Philippe Voruz et al.

Summary: Lack of awareness of cognitive impairment, specifically anosognosia, plays a key role in distinguishing between different phenotypes of post-COVID-19 conditions. The prevalence of anosognosia for memory impairment varies based on the severity of the infection. Anosognosic patients show different cognitive and psychiatric profiles compared to nosognosic patients, and there are differences in brain functional connectivity between the two groups.

BRAIN COMMUNICATIONS (2022)

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Article Clinical Neurology

Lower levels of glutathione in the anterior cingulate cortex associate with depressive symptoms and white matter hyperintensities in COVID-19 survivors

Sara Poletti et al.

Summary: The study suggests that COVID-19 survivors may experience depressive symptoms and cerebral white matter changes, which may be associated with reduced glutathione levels. It was also found that systemic inflammation can affect glutathione concentration in the ACC.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Multisystem Assessment of the Imaging Manifestations of Coagulopathy in Hospitalized Patients With Coronavirus Disease (COVID-19)

Aileen O'Shea et al.

Summary: Imaging manifestations of coagulopathy in patients with COVID-19 are common, with over one-fifth showing multisite involvement. Clinical variables poorly predict positive imaging results, highlighting the complementary role of imaging in detecting COVID-19-associated coagulopathy.

AMERICAN JOURNAL OF ROENTGENOLOGY (2021)

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Article Oncology

Diffusion tensor imaging indices to predict cognitive changes following adult radiotherapy

Noorazrul Yahya et al.

Summary: This study systematically evaluated the relationship between DTI indices and cognitive changes following radiotherapy, finding consistent associations between decreased fractional anisotropy and cognitive decline, particularly in specific regions of the cingulum and corpus callosum.

EUROPEAN JOURNAL OF CANCER CARE (2021)

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Review Immunology

Psychiatric and neuropsychiatric sequelae of COVID-19-A systematic review

Thor Mertz Schou et al.

Summary: COVID-19 patients may exhibit psychiatric symptoms such as anxiety, depression, PTSD, cognitive deficits, fatigue, and sleep disturbances. Potential risk factors include disease severity, duration of symptoms, and female sex. Survivors of COVID-19 are at risk of psychiatric sequelae, but symptoms generally improve over time.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Immunology

Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: Effect of inflammatory biomarkers at three-month follow-up

Mazza Mario Gennaro et al.

Summary: The mental health implications and cognitive status of COVID-19 pneumonia survivors were prospectively evaluated one and three months after hospital discharge. 35.8% of patients still self-rated symptoms in the clinical range in at least one psychopathological dimension at three months post-discharge. Baseline systemic immune-inflammation index predicted self-rated depressive symptomatology and cognitive impairment at three-months follow-up.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Review Neurosciences

Inflammatory neuropsychiatric disorders and COVID-19 neuroinflammation

Siu Wa Tang et al.

Summary: Neuropsychiatric sequalae to infections are emerging, with inflammation playing a role in related disorders but lacking established clinical management. COVID-19 may cause neuronal damage and cytokine storms, impacting patient prognosis, while long-term specific neuronal damages remain unclear. Adjunct anti-inflammatory treatment may benefit selected patients in neuroinflammatory conditions.

ACTA NEUROPSYCHIATRICA (2021)

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Article Clinical Neurology

Cognitive impairments four months after COVID-19 hospital discharge: Pattern, severity and association with illness variables

K. W. Miskowiak et al.

Summary: This study investigated the frequency, pattern, and severity of cognitive impairments in patients 3-4 months after COVID-19 hospital discharge, finding that a majority of patients had clinically significant cognitive impairment. These impairments were associated with subjective cognitive complaints, lower quality of life, and illness variables. Further research is needed to understand the associations between cognitive sequelae of COVID-19 and lung affection, cerebral oxygen delivery, and targeted treatments for persistent cognitive impairments.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2021)

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Article Clinical Neurology

COVID-19-related cognitive dysfunction may be associated with transient disruption in the DLPFC glutamatergic pathway

Umit Haluk Yesilkaya et al.

Summary: A 29-year-old male patient with COVID-19 developed new-onset transient attention deficit and memory problems, with MR-spectroscopy showing decreased NAA and glutamate levels in bilateral DLPFC. After three months of memory exercises, a follow-up MRS screening indicated improvement.

JOURNAL OF CLINICAL NEUROSCIENCE (2021)

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Review Biochemistry & Molecular Biology

Post-acute COVID-19 syndrome

Ani Nalbandian et al.

Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.

NATURE MEDICINE (2021)

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Review Neurosciences

The default mode network in cognition: a topographical perspective

Jonathan Smallwood et al.

Summary: The default mode network (DMN) consists of widely distributed brain regions in the parietal, temporal, and frontal cortex, showing reduced activity during attention-demanding tasks and increased activity during complex cognition tasks. DMN is located in regions furthest away from sensory and motor systems in the cortex. Leveraging knowledge of the topographic characteristics of DMN can enhance understanding of its contribution to cognition and behavior.

NATURE REVIEWS NEUROSCIENCE (2021)

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Article Medicine, General & Internal

Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study

Lovisa Hellgren et al.

Summary: A study in Sweden investigated the long-term effects of COVID-19 on brain MRI and neurocognitive function in high-risk patients, finding that most patients had abnormal MRI findings or impaired neurocognitive function, along with reported fatigue.

BMJ OPEN (2021)

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Article Medicine, General & Internal

Cognitive deficits in people who have recovered from COVID-19

Adam Hampshire et al.

Summary: This study investigates cognitive deficits in individuals who have recovered from COVID-19, showing that even asymptomatic individuals exhibit significant cognitive impairments. This suggests a multi-domain impact of COVID-19 on human cognition.

ECLINICALMEDICINE (2021)

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Article Clinical Neurology

SARS-CoV-2 can induce brain and spine demyelinating lesions

Luca Zanin et al.

ACTA NEUROCHIRURGICA (2020)

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Article Immunology

Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors

Mario Gennaro Mazza et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

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Article Multidisciplinary Sciences

Residual clinical damage after COVID-19: A retrospective and prospective observational cohort study

Rebecca De Lorenzo et al.

PLOS ONE (2020)

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Review Infectious Diseases

COVID-19 and multisystem inflammatory syndrome in children and adolescents

Li Jiang et al.

LANCET INFECTIOUS DISEASES (2020)

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Review Clinical Neurology

Magnetic resonance imaging in Alzheimer's disease and mild cognitive impairment

Avinash Chandra et al.

JOURNAL OF NEUROLOGY (2019)

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Article Clinical Neurology

Clinical characteristics associated with the discrepancy between subjective and objective cognitive impairment in depression

J. Z. Petersen et al.

JOURNAL OF AFFECTIVE DISORDERS (2019)

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Article Clinical Neurology

Structural integrity in subjective cognitive decline, mild cognitive impairment and Alzheimer's disease based on multicenter diffusion tensor imaging

Katharina Brueggen et al.

JOURNAL OF NEUROLOGY (2019)

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Article Clinical Neurology

Discrepancy between objective and subjective cognition in major depressive disorder

Maria Serra-Blasco et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2019)

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Article Geriatrics & Gerontology

Relationship Between DTI Metrics and Cognitive Function in Alzheimer's Disease

Chantel D. Mayo et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

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Article Psychiatry

The association between antidepressant treatment and brain connectivity in two double-blind, placebo-controlled clinical trials: a treatment mechanism study

Yun Wang et al.

LANCET PSYCHIATRY (2019)

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Review Neurosciences

Brodmann area 10: Collating, integrating and high level processing of nociception and pain

Ke Peng et al.

PROGRESS IN NEUROBIOLOGY (2018)

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Review Clinical Neurology

Understanding the Physiopathology Behind Axial and Radial Diffusivity Changes - What Do we Know?

Pawel J. Winklewski et al.

FRONTIERS IN NEUROLOGY (2018)

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Article Neurosciences

The Hierarchical Organization of the Default, Dorsal Attention and Salience Networks in Adolescents and Young Adults

Yuan Zhou et al.

CEREBRAL CORTEX (2018)

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Review Neurosciences

Review of functional MRI in HIV: effects of aging and medication

C. S. Hakkers et al.

JOURNAL OF NEUROVIROLOGY (2017)

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Article Public, Environmental & Occupational Health

CONSTANCES: a general prospective population-based cohort for occupational and environmental epidemiology: cohort profile

Marcel Goldberg et al.

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2017)

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Article Multidisciplinary Sciences

Discrepancy between objective and subjective cognition in adults with major depressive disorder

Manit Srisurapanont et al.

SCIENTIFIC REPORTS (2017)

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Review Rehabilitation

Diffusion-Tensor Imaging Findings and Cognitive Function Following Hospitalized Mixed-Mechanism Mild Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Lucy Oehr et al.

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION (2017)

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Article Biochemistry & Molecular Biology

Brain connectomics predict response to treatment in social anxiety disorder

S. Whitfield-Gabrieli et al.

MOLECULAR PSYCHIATRY (2016)

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Article Clinical Neurology

Screening for cognitive dysfunction in unipolar depression: Validation and evaluation of objective and subjective tools

Caroline Vintergaard Ott et al.

JOURNAL OF AFFECTIVE DISORDERS (2016)

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Article Behavioral Sciences

Working memory performance is related to intrinsic resting state functional connectivity changes in community-dwelling elderly cohort

Celine Charroud et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2016)

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Article Neurosciences

Incorporating outlier detection and replacement into a non-parametric framework for movement and distortion correction of diffusion MR images

Jesper L. R. Andersson et al.

NEUROIMAGE (2016)

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Review Psychology, Clinical

Subjective Cognitive Complaints and Objective Cognitive Function in Aging: A Systematic Review and Meta-Analysis of Recent Cross-Sectional Findings

Bridget Burmester et al.

NEUROPSYCHOLOGY REVIEW (2016)

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Review Biotechnology & Applied Microbiology

Integrating Retrogenesis Theory to Alzheimer's Disease Pathology: Insight from DTI-TBSS Investigation of the White Matter Microstructural Integrity

Gilberto Sousa Alves et al.

BIOMED RESEARCH INTERNATIONAL (2015)

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Article Clinical Neurology

Multivariate Classification of Blood Oxygen Level-Dependent fMRI Data with Diagnostic Intention: A Clinical Perspective

B. Sundermann et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2014)

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Article Multidisciplinary Sciences

Modulatory interactions between the default mode network and task positive networks in resting-state

Xin Di et al.

PEERJ (2014)

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Article Neurosciences

Dynamic functional reorganizations and relationship with working memory performance in healthy aging

Roser Sala-Llonch et al.

FRONTIERS IN HUMAN NEUROSCIENCE (2012)

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Review Neurosciences

Multivariate pattern analysis of fMRI: The early beginnings

James V. Haxby

NEUROIMAGE (2012)

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Article Endocrinology & Metabolism

Obesity Is Associated With Reduced White Matter Integrity in Otherwise Healthy Adults

Kelly M. Stanek et al.

OBESITY (2011)

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Multiple Indices of Diffusion Identifies White Matter Damage in Mild Cognitive Impairment and Alzheimer's Disease

Laurence O'Dwyer et al.

PLOS ONE (2011)

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Article Geriatrics & Gerontology

Age-related alterations in default mode network: Impact on working memory performance

Fabio Sambataro et al.

NEUROBIOLOGY OF AGING (2010)

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Article Neurosciences

Right frontopolar cortex activity correlates with reliability of retrospective rating of confidence in short-term recognition memory performance

Osamu Yokoyama et al.

NEUROSCIENCE RESEARCH (2010)

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Bayesian analysis of neuroimaging data in FSL

Mark W. Woolrich et al.

NEUROIMAGE (2009)

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Threshold-free cluster enhancement: Addressing problems of smoothing, threshold dependence and localisation in cluster inference

Stephen M. Smith et al.

NEUROIMAGE (2009)

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Review Behavioral Sciences

Cognitive reserve

Yaakov Stern

NEUROPSYCHOLOGIA (2009)

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Article Neurosciences

Reduced resting-state brain activity in the default network in normal aging

J. S. Damoiseaux et al.

CEREBRAL CORTEX (2008)

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Article Neurosciences

Neural correlates of memory confidence

Steffen Moritz et al.

NEUROIMAGE (2006)

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Article Neurosciences

Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data

Stephen M. Smith et al.

NEUROIMAGE (2006)

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Understanding metamemory: Neural correlates of the cognitive process and subjective level of confidence in recognition memory

EF Chua et al.

NEUROIMAGE (2006)

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Review Geriatrics & Gerontology

Subjective memory complaints and cognitive impairment in older people

Louise M. Reid et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2006)

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Article Multidisciplinary Sciences

Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI

MD Greicius et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Article Neurosciences

Nonparametric permutation tests for functional neuroimaging: A primer with examples

TE Nichols et al.

HUMAN BRAIN MAPPING (2002)

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Article Computer Science, Artificial Intelligence

A global optimisation method for robust affine registration of brain images

M Jenkinson et al.

MEDICAL IMAGE ANALYSIS (2001)

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Brain correlates of subjective cognitive complaints in COVID-19 survivors: A multimodal magnetic resonance imaging study

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