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miR-489 inhibits proliferation, cell cycle progression and induces apoptosis of glioma cells via targeting SPIN1-mediated PI3K/AKT pathway
Yan Li et al.
BIOMEDICINE & PHARMACOTHERAPY (2017)
Long Noncoding RNA AFAP1-AS1 Promotes Cell Proliferation and Apoptosis of Gastric Cancer Cells via PTEN/p-AKT Pathway
Jun-qiang Guo et al.
DIGESTIVE DISEASES AND SCIENCES (2017)
An increase in long non-coding RNA PANDAR is associated with poor prognosis in clear cell renal cell carcinoma
Yi Xu et al.
BMC CANCER (2017)
Vorinostat, a histone deacetylase (HDAC) inhibitor, promotes cell cycle arrest and re-sensitizes rituximab- and chemo-resistant lymphoma cells to chemotherapy agents
Kai Xue et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2016)
Uvangoletin induces mitochondria-mediated apoptosis in HL-60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances
Zhuanzhen Zheng et al.
ONCOLOGY REPORTS (2016)
Antiapoptotic Bcl-2 protein as a potential target for cancer therapy: A mini review
Hitesh Jagani et al.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2016)
MicroRNA-30 inhibits antiapoptotic factor Mcl-1 in mouse and human hematopoietic cells after radiation exposure
Xiang Hong Li et al.
APOPTOSIS (2016)
MicroRNA-744 inhibited cervical cancer growth and progression through apoptosis induction by regulating Bcl-2
Xiao-Fang Chen et al.
BIOMEDICINE & PHARMACOTHERAPY (2016)
Long noncoding RNA HULC predicts poor clinical outcome and represents pro-oncogenic activity in diffuse large B-cell lymphoma
Wei Peng et al.
BIOMEDICINE & PHARMACOTHERAPY (2016)
Silence of long noncoding RNA UCA1 inhibits malignant proliferation and chemotherapy resistance to adriamycin in gastric cancer
Chao Shang et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2016)
Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and synergizes with antimicrotubule drugs
Michael Torsten Meister et al.
CANCER LETTERS (2016)
Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane
Katelyn L. O'Neill et al.
GENES & DEVELOPMENT (2016)
Silibinin-Induced Apoptosis and Downregulation of MicroRNA-21 and MicroRNA-155 in MCF-7 Human Breast Cancer Cells
Masoud Maleki Zadeh et al.
JOURNAL OF BREAST CANCER (2016)
The lncRNA MALAT1 functions as a competing endogenous RNA to regulate MCL-1 expression by sponging miR-363-3p in gallbladder cancer
Shou-Hua Wang et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2016)
MiR-23b targets cyclin G1 and suppresses ovarian cancer tumorigenesis and progression
Jing Yan et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2016)
Anacardic Acids from Knema hookeriana as Modulators of Bcl-xL/Bak and Mcl-1/Bid Interactions
Charlotte Geny et al.
JOURNAL OF NATURAL PRODUCTS (2016)
Safety, tolerability, and preliminary activity of CUDC-907, a first-in-class, oral, dual inhibitor of HDAC and PI3K, in patients with relapsed or refractory lymphoma or multiple myeloma: an open-label, dose-escalation, phase 1 trial
Anas Younes et al.
LANCET ONCOLOGY (2016)
MicroRNA-505 functions as a tumor suppressor in endometrial cancer by targeting TGF-α
Shuo Chen et al.
MOLECULAR CANCER (2016)
Metformin induces apoptosis by microRNA-26a-mediated downregulation of myeloid cell leukaemia-1 in human oral cancer cells
Fang Wang et al.
MOLECULAR MEDICINE REPORTS (2016)
MicroRNA-21 expression is associated with the clinical features of patients with gastric carcinoma and affects the proliferation, invasion and migration of gastric cancer cells by regulating Noxa
Haibin Sun et al.
MOLECULAR MEDICINE REPORTS (2016)
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia
Andrew W. Roberts et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model
Tomoya Takeda et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)
Isoledene from Mesua ferrea oleo-gum resin induces apoptosis in HCT 116 cells through ROS-mediated modulation of multiple proteins in the apoptotic pathways: A mechanistic study
Muhammad Asif et al.
TOXICOLOGY LETTERS (2016)
Down-regulation of miR-320 associated with cancer progression and cell apoptosis via targeting Mcl-1 in cervical cancer
Ting Zhang et al.
TUMOR BIOLOGY (2016)
The miR-644a/CTBP1/p53 axis suppresses drug resistance by simultaneous inhibition of cell survival and epithelial-mesenchymal transition in breast cancer
Umar Raza et al.
ONCOTARGET (2016)
LncRNA H19 confers chemoresistance in ERα-positive breast cancer through epigenetic silencing of the pro-apoptotic gene BIK
Xinxin Si et al.
ONCOTARGET (2016)
MEG3, HCN3 and linc01105 influence the proliferation and apoptosis of neuroblastoma cells via the HIF-1α and p53 pathways
Weitao Tang et al.
SCIENTIFIC REPORTS (2016)
Anticancer bioactive peptide-3 inhibits human gastric cancer growth by targeting miR-338-5p
Zhiwei Xing et al.
CELL AND BIOSCIENCE (2016)
Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer
Pallab Ray et al.
SCIENTIFIC REPORTS (2016)
Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies
Alex R. D. Delbridge et al.
NATURE REVIEWS CANCER (2016)
A fate worse than death: apoptosis as an oncogenic process
Gabriel Ichim et al.
NATURE REVIEWS CANCER (2016)
Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors
Yichao Wan et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells
Mohammad Hassan Naseri et al.
CANCER CELL INTERNATIONAL (2015)
Functional studies of miR-130a on the inhibitory pathways of apoptosis in patients with chronic myeloid leukemia
X. Zhu et al.
CANCER GENE THERAPY (2015)
Growth differentiation factor-15 encodes a novel microRNA 3189 that functions as a potent regulator of cell death
M. F. Jones et al.
CELL DEATH AND DIFFERENTIATION (2015)
MiR-429 Induces Gastric Carcinoma Cell Apoptosis Through BcI-2
Ping Zhu et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)
Long Non-Coding RNA MEG3 Inhibits Cell Proliferation and Induces Apoptosis in Prostate Cancer
Gang Luo et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)
miR-137 and miR-197 Induce Apoptosis and Suppress Tumorigenicity by Targeting MCL-1 in Multiple Myeloma
Yijun Yang et al.
CLINICAL CANCER RESEARCH (2015)
Synthesis and biological evaluation of a novel betulinic acid derivative as an inducer of apoptosis in human colon carcinoma cells (HT-29)
Biswajit Chakraborty et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
Down-regulated expression of miR-134 contributes to paclitaxel resistance in human ovarian cancer cells
Ting Shuang et al.
FEBS LETTERS (2015)
A Time to Kill: Targeting Apoptosis in Cancer
Jean L. Koff et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)
ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development
Shundong Cang et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2015)
Structure-Based Lead Optimization and Biological Evaluation of BAX Direct Activators as Novel Potential Anticancer Agents
Mariano Stornaiuolo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Tamoxifen-Induced Cell Death of Malignant Glioma Cells Is Brought About by Oxidative-Stress-Mediated Alterations in the Expression of BCL2 Family Members and Is Enhanced on miR-21 Inhibition
Mugdha Harmalkar et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2015)
Profiling of Virus-Encoded MicroRNAs in Epstein-Barr Virus-Associated Gastric Carcinoma and Their Roles in Gastric Carcinogenesis
Aya Shinozaki-Ushiku et al.
JOURNAL OF VIROLOGY (2015)
Obatoclax in combination with fludarabine and rituximab is well-tolerated and shows promising clinical activity in relapsed chronic lymphocytic leukemia
Jennifer R. Brown et al.
LEUKEMIA & LYMPHOMA (2015)
miR-377-dependent BCL-xL regulation drives chemotherapeutic resistance in B-cell lymphoid malignancies
Sayer Al-Harbi et al.
MOLECULAR CANCER (2015)
p53 upregulated modulator of apoptosis sensitizes drug-resistant U251 glioblastoma stem cells to temozolomide through enhanced apoptosis
Wang Miao et al.
MOLECULAR MEDICINE REPORTS (2015)
microRNA-10b Is Overexpressed and Critical for Cell Survival and Proliferation in Medulloblastoma
Rekha Pal et al.
PLOS ONE (2015)
miR-335 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells through direct suppression of BCL-W
Kefeng Wang et al.
TUMOR BIOLOGY (2015)
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
J. D. Leverson et al.
CELL DEATH & DISEASE (2015)
miR-193a-3p is a potential tumor suppressor in malignant pleural mesothelioma
Marissa Williams et al.
ONCOTARGET (2015)
Concurrent Targeting of KRAS and AKT by MiR-4689 Is a Novel Treatment Against Mutant KRAS Colorectal Cancer
Masayuki Hiraki et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2015)
MicroRNA-195 Chemosensitizes Colon Cancer Cells to the Chemotherapeutic Drug Doxorubicin by Targeting the First Binding Site of BCL2L2 mRNA
Juan Qu et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2015)
3-Hydroxy-3′,4′-dimethoxyflavone suppresses Bcl-w-induced invasive potentials and sternness in glioblastoma multiforme
In Hwa Bae et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein
Andrew M. Petros et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway
B. Zhang et al.
BRITISH JOURNAL OF CANCER (2014)
Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells
K. S. Siveen et al.
BRITISH JOURNAL OF CANCER (2014)
Antitumor effect of miR-197 targeting in p53 wild-type lung cancer
M. E. Fiori et al.
CELL DEATH AND DIFFERENTIATION (2014)
MicroRNA-363-mediated downregulation of S1PR1 suppresses the proliferation of hepatocellular carcinoma cells
Peng Zhou et al.
CELLULAR SIGNALLING (2014)
A Phase II, Multicenter, Open-Label Study of Obatoclax Mesylate in Patients With Previously Untreated Myelodysplastic Syndromes With Anemia or Thrombocytopenia
Martha L. Arellano et al.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2014)
Chalcones with electron-withdrawing and electron-donating substituents: Anticancer activity against TRAIL resistant cancer cells, structure-activity relationship analysis and regulation of apoptotic proteins
Chun Wai Mai et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Baicalein attenuates proteasome inhibition-induced apoptosis by suppressing the activation of the mitochondrial pathway and the caspase-8-and Bid-dependent pathways
Eun Byul Jung et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2014)
Gossypol Increases Expression of the Pro-apoptotic BH3-only Protein NOXA through a Novel Mechanism Involving Phospholipase A2, Cytoplasmic Calcium, and Endoplasmic Reticulum Stress
Ryan S. Soderquist et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Endiandric Acid Analogues from Beilschmiedia ferruginea as Dual Inhibitors of Bcl-xL/Bak and Mcl-1/Bid Interactions
Cecile Apel et al.
JOURNAL OF NATURAL PRODUCTS (2014)
Activation of the Proapoptotic Bcl-2 Protein Bax by a Small Molecule Induces Tumor Cell Apoptosis
Guoping Zhao et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
miR-511 induces the apoptosis of radioresistant lung adenocarcinoma cells by triggering BAX
Han-Han Zhang et al.
ONCOLOGY REPORTS (2014)
BM-1197: A Novel and Specific Bcl-2/Bcl-xL Inhibitor Inducing Complete and Long-Lasting Tumor Regression In Vivo
Longchuan Bai et al.
PLOS ONE (2014)
A miRNA Signature of Chemoresistant Mesenchymal Phenotype Identifies Novel Molecular Targets Associated with Advanced Pancreatic Cancer
Alakesh Bera et al.
PLOS ONE (2014)
MicroRNA-34a Targets Bcl-2 and Sensitizes Human Hepatocellular Carcinoma Cells to Sorafenib Treatment
Fan Yang et al.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2014)
Many players in BCL-2 family affairs
Tudor Moldoveanu et al.
TRENDS IN BIOCHEMICAL SCIENCES (2014)
miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation
C. Denoyelle et al.
CELL DEATH & DISEASE (2014)
Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies?
K. Brinkmann et al.
CELL DEATH & DISEASE (2014)
Small-molecule Bax agonists for cancer therapy
Meiguo Xin et al.
NATURE COMMUNICATIONS (2014)
MicroRNA-206 suppresses gastric cancer cell growth and metastasis
Jun Ren et al.
CELL AND BIOSCIENCE (2014)
A new bisphosphonate derivative, CP, induces gastric cancer cell apoptosis via activation of the ERK1/2 signaling pathway
Hai-jun Wang et al.
ACTA PHARMACOLOGICA SINICA (2013)
Ionizing radiation-inducible microRNA miR-193a-3p induces apoptosis by directly targeting Mcl-1
Jeong-Eun Kwon et al.
APOPTOSIS (2013)
MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells
Chung-Ching Chio et al.
ARCHIVES OF TOXICOLOGY (2013)
Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer
K. Kavitha et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)
Cationic microRNA-delivering nanovectors with bifunctional peptides for efficient treatment of PANC-1 xenograft model
Q. L. Hu et al.
BIOMATERIALS (2013)
3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1
Ting Song et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
MicroRNA-133a, downregulated in osteosarcoma, suppresses proliferation and promotes apoptosis by targeting Bcl-xL and Mcl-1
Fang Ji et al.
BONE (2013)
Genista sessilifolia DC. extracts induce apoptosis across a range of cancer cell lines
P. Bontempo et al.
CELL PROLIFERATION (2013)
MiR-139 Inhibits Mcl-1 Expression and Potentiates TMZ-Induced Apoptosis in Glioma
Rui-Yan Li et al.
CNS NEUROSCIENCE & THERAPEUTICS (2013)
Fisetin inhibits growth, induces G2/M arrest and apoptosis of human epidermoid carcinoma A431 cells: role of mitochondrial membrane potential disruption and consequent caspases activation
Harish C. Pal et al.
EXPERIMENTAL DERMATOLOGY (2013)
Daidzein causes cytochrome c-mediated apoptosis via the Bcl-2 family in human hepatic cancer cells
Hyun Jin Park et al.
FOOD AND CHEMICAL TOXICOLOGY (2013)
MicroRNA-205, a novel regulator of the anti-apoptotic protein Bcl2, is downregulated in prostate cancer
Berlinda Verdoodt et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2013)
Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
Anders Friberg et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X-L
Brad E. Sleebs et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
A Potent and Highly Efficacious Bcl-2/Bcl-xL Inhibitor
Angelo Aguilar et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Discovery of Potent Mcl-1/Bcl-xL Dual Inhibitors by Using a Hybridization Strategy Based on Structural Analysis of Target Proteins
Yuta Tanaka et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Hypoxia inducible factor-1α induces chemoresistance phenotype in non-Hodgkin lymphoma cell line via up-regulation of Bcl-xL
Marco A. Hernandez-Luna et al.
LEUKEMIA & LYMPHOMA (2013)
Mcl-1 is essential for the survival of plasma cells
Victor Peperzak et al.
NATURE IMMUNOLOGY (2013)
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Andrew J. Souers et al.
NATURE MEDICINE (2013)
BID-induced structural changes in BAK promote apoptosis
Tudor Moldoveanu et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R
J. Gong et al.
ONCOGENE (2013)
Oncomir miR-125b Suppresses p14ARF to Modulate p53-Dependent and p53-Independent Apoptosis in Prostate Cancer
Sumaira Amir et al.
PLOS ONE (2013)
Correction: MiR-26a Inhibits Proliferation and Migration of Breast Cancer through Repression of MCL-1
Jie Gao et al.
PLoS One (2013)
Tetrandrine Induces Mitochondria-Mediated Apoptosis in Human Gastric Cancer BGC-823 Cells
Rong Qin et al.
PLOS ONE (2013)
Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a synthetic resveratrol analogue
Hanna Piotrowska et al.
TOXICOLOGY IN VITRO (2013)
MicroRNA-200a/b influenced the therapeutic effects of curcumin in hepatocellular carcinoma (HCC) cells
Hung-Hua Liang et al.
TUMOR BIOLOGY (2013)
Mechanisms of Action of Bcl-2 Family Proteins
Aisha Shamas-Din et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
Cellular Mechanisms Controlling Caspase Activation and Function
Amanda B. Parrish et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
Tumor suppressor PDCD4 modulates miR-184-mediated direct suppression of C-MYC and BCL2 blocking cell growth and survival in nasopharyngeal carcinoma
Yan Zhen et al.
CELL DEATH & DISEASE (2013)
Removal of the BH4 Domain from Bcl-2 Protein Triggers an Autophagic Process that Impairs Tumor Growth
Daniela Trisciuoglio et al.
NEOPLASIA (2013)
MiR-125b Inhibits Tumor Growth and Promotes Apoptosis of Cervical Cancer Cells by Targeting Phosphoinositide 3-Kinase Catalytic Subunit Delta
Fang Cui et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2012)
Heat Shock Protein 90B1 Plays an Oncogenic Role and is a Target of microRNA-223 in Human Osteosarcoma
Guodong Li et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2012)
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
Stefan P. Glaser et al.
GENES & DEVELOPMENT (2012)
Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells
Chenjuan Zhou et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2012)
Targeting the B-Cell Lymphoma/Leukemia 2 Family in Cancer
Matthew S. Davids et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
Design of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New Scaffold
Haibin Zhou et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
MicroRNA miR-491-5p Targeting both TP53 and Bcl-XL Induces Cell Apoptosis in SW1990 Pancreatic Cancer Cells through Mitochondria Mediated Pathway
Rong Guo et al.
MOLECULES (2012)
New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy
J. S. Long et al.
ONCOGENE (2012)
Selective Induction of Cell Death in Melanoma Cell Lines through Targeting of Mcl-1 and A1
Daniela Senft et al.
PLOS ONE (2012)
MiR-200c Regulates Noxa Expression and Sensitivity to Proteasomal Inhibitors
Mikael Lerner et al.
PLOS ONE (2012)
Molecular biology of Bax and Bak activation and action
Dana Westphal et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
BH3-only proteins: Orchestrators of apoptosis
Aisha Shamas-Din et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways
L. Zhang et al.
CELL DEATH AND DIFFERENTIATION (2011)
The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy
P. N. Kelly et al.
CELL DEATH AND DIFFERENTIATION (2011)
microRNA-203 suppresses bladder cancer development by repressing bcl-w expression
Juanjie Bo et al.
FEBS JOURNAL (2011)
3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) Based Molecules as Potent, Dual Inhibitors of B-Cell Lymphoma 2 (Bcl-2) and Myeloid Cell Leukemia Sequence 1 (Mcl-1): Structure-Based Design and Structure-Activity Relationship Studies
Zhichao Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
MicroRNA-199a-3p Is Downregulated in Human Osteosarcoma and Regulates Cell Proliferation and Migration
Zhenfeng Duan et al.
MOLECULAR CANCER THERAPEUTICS (2011)
Cellular Stress Induced Alterations in MicroRNA let-7a and let-7b Expression Are Dependent on p53
Anthony D. Saleh et al.
PLOS ONE (2011)
Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR
Andrew M. Petros et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells
Antonio F. Santidrian et al.
BLOOD (2010)
Bid integrates intrinsic and extrinsic signaling in apoptosis induced by α-tocopheryl succinate in human gastric carcinoma cells
Yan Zhao et al.
CANCER LETTERS (2010)
Fisetin induces apoptosis in Huh-7 cells via downregulation of BIRC8 and Bcl2L2
Ju Yeon Kim et al.
FOOD AND CHEMICAL TOXICOLOGY (2010)
Functional screening identifies a microRNA, miR-491 that induces apoptosis by targeting Bcl-XL in colorectal cancer cells
Haruo Nakano et al.
INTERNATIONAL JOURNAL OF CANCER (2010)
Apoptotic Regulation by MCL-1 through Heterodimerization
Qian Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma
Satoshi Shimizu et al.
JOURNAL OF HEPATOLOGY (2010)
Synthesis and Biological Evaluation of Apogossypolone Derivatives as Pan-active Inhibitors of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins
Jun Wei et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Design, Synthesis, and Interaction Study of Quinazoline-2(1H)-thione Derivatives as Novel Potential Bcl-xL Inhibitors
Yu Feng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
BI-97C1, an Optically Pure Apogossypol Derivative as Pan-Active Inhibitor of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins
Jun Wei et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Gymnochromes E and F, Cytotoxic Phenanthroperylenequinones from a Deep-Water Crinoid, Holopus rangii
Hilaire V. Kemami Wangun et al.
JOURNAL OF NATURAL PRODUCTS (2010)
Cryptosphaerolide, a Cytotoxic Mcl-1 Inhibitor from a Marine-Derived Ascomycete Related to the Genus Cryptosphaeria
Hyuncheol Oh et al.
JOURNAL OF NATURAL PRODUCTS (2010)
The Novel Tryptamine Derivative JNJ-26854165 Induces Wild-Type p53-and E2F1-Mediated Apoptosis in Acute Myeloid and Lymphoid Leukemias
Kensuke Kojima et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
Wyndham H. Wilson et al.
LANCET ONCOLOGY (2010)
Lyn Kinase-Dependent Regulation of miR181 and Myeloid Cell Leukemia-1 Expression: Implications for Drug Resistance in Myelogenous Leukemia
Eric I. Zimmerman et al.
MOLECULAR PHARMACOLOGY (2010)
A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy
W. J. Placzek et al.
CELL DEATH & DISEASE (2010)
Bcl-2 family on guard at the ER
Eva Szegezdi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)
Genistein sensitizes human hepatocellular carcinoma cells to TRAIL-mediated apoptosis by enhancing Bid cleavage
Cheng-Yun Jin et al.
ANTI-CANCER DRUGS (2009)
MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer
Melissa Crawford et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
A rice bran polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis
Carrie K. L. Kong et al.
BIOCHEMICAL PHARMACOLOGY (2009)
Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors
John Porter et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
MicroRNA-101, Down-regulated in Hepatocellular Carcinoma, Promotes Apoptosis and Suppresses Tumorigenicity
Hang Su et al.
CANCER RESEARCH (2009)
Targeting the Apoptosome for Cancer Therapy
Elizabeth C. Ledgerwood et al.
CLINICAL CANCER RESEARCH (2009)
The role of microRNA expression pattern in human intrahepatic cholangiocarcinoma
Lei Chen et al.
JOURNAL OF HEPATOLOGY (2009)
Apogossypol Derivatives as Pan-Active Inhibitors of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins
Jun Wei et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
NMR Strategy for Unraveling Structures of Bioactive Sponge-Derived Oxy-polyhalogenated Diphenyl Ethers
Laurent Calcul et al.
JOURNAL OF NATURAL PRODUCTS (2009)
Dehydrocostuslactone disrupts signal transducers and activators of transcription 3 through up-regulation of suppressor of cytokine signaling in breast cancer cells
Po-Lin Kuo et al.
MOLECULAR CANCER THERAPEUTICS (2009)
Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells
Y. Saito et al.
ONCOGENE (2009)
MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family
L. J. Beverly et al.
ONCOGENE (2009)
Surgical Treatment of Pancreatic Cancer
Martin Loos et al.
RECENT ADVANCES IN CLINICAL ONCOLOGY (2008)
miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines
Cliff Ji-Fan Lin et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?
V. Labi et al.
CELL DEATH AND DIFFERENTIATION (2008)
Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins
Cheol-Min Park et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities
Desiree Bonci et al.
NATURE MEDICINE (2008)
The BCL-2 protein family: opposing activities that mediate cell death
Richard J. Youle et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
BH3-only proteins in apoptosis and beyond: an overview
E. Lomonosova et al.
ONCOGENE (2008)
Bid: a Bax-like BH3 protein
L. P. Billen et al.
ONCOGENE (2008)
PUMA, a potent killer with or without p53
J. Yu et al.
ONCOGENE (2008)
Preventive effect of Ganoderma amboinense on acetaminophen-induced acute liver injury
Cheng-chin Hsu et al.
PHYTOMEDICINE (2008)
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
Mai Nguyen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition
Mikhail A. Nikiforov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
mir-29 regulates Mcl-1 protein expression and apoptosis
J. L. Mott et al.
ONCOGENE (2007)
Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic bcl-2 proteins
Guozhi Tang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
BCL2L2 is a probable target for novel 14q11.2 amplification detected in a non-small cell lung cancer cell line
Tsutomu Kawasaki et al.
CANCER SCIENCE (2007)
Noxa up-regulation and Mcl-1 cleavage are associated to apoptosis induction by bortezomib in multiple myeloma
Patricia Gomez-Bougie et al.
CANCER RESEARCH (2007)
Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins
Guozhi Tang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells
Azhar R. Hussain et al.
CANCER RESEARCH (2007)
Studies leading to potent, dual inhibitors of bcl-2 and Bcl-xL
Milan Bruncko et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
Simon N. Willis et al.
SCIENCE (2007)
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas
Cinta Mestre-Escorihuela et al.
BLOOD (2007)
Safety, pharmacokinetics, and preliminary antitumor activity of sorafenib: A review of four phase I trials in patients with advanced refractory solid tumors
Dirk Strumberg et al.
ONCOLOGIST (2007)
Apoptosis: A review of programmed cell death
Susan Elmore
TOXICOLOGIC PATHOLOGY (2007)
Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer
Jignesh M. Doshi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
Mark F. van Delft et al.
CANCER CELL (2006)
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins
Guoping Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
BCL2 family in DNA damage and cell cycle control
S. Zinkel et al.
CELL DEATH AND DIFFERENTIATION (2006)
Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3′-kinase/Akt pathway and Bcl-2 family proteins
Moammir H. Aziz et al.
MOLECULAR CANCER THERAPEUTICS (2006)
miR-15 and miR-16 induce apoptosis by targeting BCL2
A Cimmino et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Effects of antioxidants and caspase-3 inhibitor on the phenylethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells
SJ Wu et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2005)
Structural conservation of residues in BH1 and BH2 domains of Bcl-2 family proteins
GU Gurudutta et al.
FEBS LETTERS (2005)
Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis of cancer cells
CH Li et al.
LIFE SCIENCES (2005)
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
T Oltersdorf et al.
NATURE (2005)
Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species
SV Singh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Indomethacin-induced activation of the death receptor-mediated apoptosis pathway circumvents acquired doxorubicin resistance in SCLC cells
DJA de Groot et al.
BRITISH JOURNAL OF CANCER (2005)
E1A activates transcription of p73 and noxa to induce apoptosis
M Flinterman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
L Chen et al.
MOLECULAR CELL (2005)
Overview of cell death signaling pathways
ZY Jin et al.
CANCER BIOLOGY & THERAPY (2005)
Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis
T Hershko et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Bcl-2 family members and disease
CM Sorenson
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)
Structural biology of the Bcl-2 family of proteins
AM Petros et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
R Ley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK
M Unoki et al.
ONCOGENE (2003)
Oblimersen sodium (G3139 bcl-2 antisense oligonucleotide) therapy in Waldenstrom's macroglobulinemia: A targeted approach to enhance apoptosis
SR Frankel
SEMINARS IN ONCOLOGY (2003)
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
A Letai et al.
CANCER CELL (2002)
Death and anti-death: Tumour resistance to apoptosis
FH Igney et al.
NATURE REVIEWS CANCER (2002)
MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis
RW Craig
LEUKEMIA (2002)
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2
C Adrain et al.
EMBO JOURNAL (2001)
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway
M Unoki et al.
ONCOGENE (2001)
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
WX Zong et al.
GENES & DEVELOPMENT (2001)
Structure of Bax: Coregulation of dimer formation and intracellular localization
M Suzuki et al.
CELL (2000)
Nora, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
E Oda et al.
SCIENCE (2000)
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