A comprehensive overview of PPM1B: From biological functions to diseases

Reversible phosphorylation of proteins is an important mechanism that regulates cellular processes, which are precisely regulated by protein kinases and phosphatases. PPM1B is a metal ion-dependent serine/threonine protein phosphatase, which regulates multiple biological functions by targeting substrate dephosphorylation, such as cell cycle, energy metabolism, inflammatory responses. In this review, we summarized the occurrent understandings of PPM1B focused on its regulation of signaling pathways, related diseases, and small-molecular inhibitors, which may provide new insights for the identification of PPM1B inhibitors and the treatment of PPM1B-related diseases.

Automated summary

Reversible phosphorylation of proteins is regulated by protein kinases and phosphatases, with PPM1B being a metal ion-dependent serine/threonine protein phosphatase. PPM1B regulates various biological functions by dephosphorylating substrates, including cell cycle, energy metabolism, and inflammatory responses. This review provides a summary of the current understanding of PPM1B regarding its regulation of signaling pathways, associated diseases, and potential small-molecule inhibitors, offering new insights for the development of PPM1B inhibitors and the treatment of PPM1B-related diseases.