Real-world evidence for beneficial effects of dipyrone in 4,278 patients with pulmonary hypertension-Analysis of the risk of ventilation, hospitalization, and agranulocytosis

Article Dermatology

Real-world evidence from over one million COVID-19 vaccinations is consistent with reactivation of the varicella-zoster virus

M. Hertel et al.

Summary: This study based on real-world data assesses whether the incidence of herpes zoster (HZ) increases after COVID-19 vaccination. The results show a significantly higher incidence of HZ in vaccinated individuals compared to unvaccinated individuals, suggesting a rare adverse drug reaction to COVID-19 vaccines.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

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Article Obstetrics & Gynecology

Fetal adverse effects following NSAID or metamizole exposure in the 2nd and 3rd trimester: an evaluation of the German Embryotox cohort

Katarina Dathe et al.

Summary: This study investigates the outcomes of pregnancies exposed to NSAID and/or metamizole in the 2nd and/or 3rd trimester compared to those exposed only in the 1st trimester. The study suggests that NSAID use in the 2nd trimester may pose a risk of oligohydramnios and ductus arteriosus constriction.

BMC PREGNANCY AND CHILDBIRTH (2022)

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Article Cardiac & Cardiovascular Systems

Excess Mortality in Aspirin and Dipyrone (Metamizole) Co-Medicated in Patients With Cardiovascular Disease: A Nationwide Study

Amin Polzin et al.

Summary: The combination of aspirin and dipyrone was associated with higher mortality, myocardial infarction, and stroke/transient ischemic attack rates in this nationwide analysis, caution should be exercised when using dipyrone in aspirin-treated patients for secondary prevention.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Physiology

Pediatric Pulmonary Hypertension: Definitions, Mechanisms, Diagnosis, and Treatment

Devashis Mukherjee et al.

Summary: Pediatric pulmonary hypertension is a multifactorial disease with diverse etiologies and presenting features, often hidden within other lung diseases. Factors such as lung development and genetic conditions play a significant role in the disease, requiring therapies that focus on pulmonary vasodilators and strategies to restore lung growth. Infants and children with PH have varying outcomes, with the best results seen in cases like persistent pulmonary hypertension (PPHN) and reversible lung diseases.

COMPREHENSIVE PHYSIOLOGY (2021)

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Article Pharmacology & Pharmacy