期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 185, 期 -, 页码 183-189出版社
ELSEVIER
DOI: 10.1016/j.ejpb.2023.02.017
关键词
Electromagnetic field; Rotating magnetic field; Active pharmaceutical ingredients; Transdermal drug delivery; Skin barrier
The paper presents a method of increasing the permeability of various active substances through the skin by using a rotating magnetic field. The study used 50 Hz RMF and various active pharmaceutical ingredients (APIs) to investigate the effects. It was found that exposure to RMF increased drug transport through the skin, and the release profiles varied depending on the active substance used.
The paper presents a method of increasing the permeability of various active substances through the skin by means of a rotating magnetic field. The study used 50 Hz RMF and various active pharmaceutical ingredients (APIs) such as caffeine, ibuprofen, naproxen, ketoprofen, and paracetamol. Various concentrations of active substance solutions in ethanol were used in the research, corresponding to those in commercial preparations. Each experiment was conducted for 24 h. It was shown that, regardless of the active compound used, an increase in drug transport through the skin was observed with RMF exposure. Furthermore, the release profiles depended on the active substance used. Exposure to a rotating magnetic field has been shown to effectively increase the permeability of an active substance through the skin.
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