期刊
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 188, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ejps.2023.106501
关键词
Vaginal drug delivery; 3d printing; Drug repurposing; Fibrosis; Endometriosis
Gynaecological health is an overlooked area of research that requires the development of dosage forms for diseases such as endometriosis. In this study, a 3D-printed semisolid vaginal ovule containing pirfenidone, a drug candidate for endometriosis, was developed. The 3D-printed ovule showed controlled release of pirfenidone and better mucoadhesive properties compared to standard excipients. This work opens up possibilities for further preclinical and clinical studies on vaginally administered pirfenidone as a treatment for endometriosis.
Gynaecological health is a neglected field of research that includes conditions such as endometriosis, uterine fibroids, infertility, viral and bacterial infections, and cancers. There is a clinical need to develop dosage forms for gynecological diseases that increase efficacy and reduce side effects and explore new materials with properties tailored to the vaginal mucosa and milieu. Here, we developed a 3D printed semisolid vaginal ovule containing pirfenidone, a repurposed drug candidate for endometriosis. Vaginal drug delivery allows direct targeting of the reproductive organs via the first uterine pass effect, but vaginal dosage forms can be challenging to self-administer and retain in situ for periods of more than 1-3 h. We show that a semisoft alginate-based vaginal suppository manufactured using semisolid extrusion additive manufacturing is superior to vaginal ovules made using standard excipients. The 3D-printed ovule showed a controlled release profile of pirfenidone in vitro in standard and biorelevant release tests, as well as better mucoadhesive properties ex vivo. An exposure time of 24 h of pirfenidone to a monolayer culture of an endometriotic epithelial cell line, 12Z, is necessary to reduce the cells' metabolic activity, which demonstrates the need for a sustained release formulation of pirfenidone. 3D printing allowed us to formulate mucoadhesive polymers into a semisolid ovule with controlled release of pirfenidone. This work enables further preclinical and clinical studies into vaginally administered pirfenidone to assess its efficacy as a repurposed endometriosis treatment.
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