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Review
Anesthesiology
Giulia Di Stefano et al.
Summary: This systematic review and meta-analysis examined the frequency of neuropathic pain associated with COVID-19. Through the analysis of 17 studies and 6 reports, the frequency of neuropathic pain was found to range from 0.4% to 25%, with an overall estimated frequency of 10%. The studies showed heterogeneity, and there was poor description of the diagnostic criteria for neuropathic pain.
EUROPEAN JOURNAL OF PAIN
(2023)
Review
Pharmacology & Pharmacy
Josuel Ora et al.
Summary: Long-COVID, characterized by persistent symptoms after 4 weeks of initial infection, affects 1 in 5 individuals and its underlying mechanisms are yet to be fully understood. This article provides an overview of current and ongoing therapies for long-COVID syndrome, with a focus on clinical trials and underlying mechanisms. Despite the lack of established treatments, pharmacological research is exploring drugs that target systemic inflammation and rehabilitation appears to be a safe option. Further research and trials are needed to better understand the pathogenesis and develop effective treatments.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Review
Rheumatology
Atanu Pal et al.
Summary: This study aimed to describe the clinical profile and treatment outcome of 23 patients with post-COVID-19 Reactive Arthritis (ReA). The results showed that ReA is mainly characterized by asymmetric oligoarthritis involving the lower limbs, with a higher prevalence in females. The knee joint was the most commonly affected joint, and axial symptoms and enthesitis were often coexistent. Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) and steroids showed good efficacy.
REUMATOLOGIA CLINICA
(2023)
Article
Public, Environmental & Occupational Health
Lucia Spicuzza et al.
Summary: The study found that at 4 months follow-up, women recovered from COVID-19 pneumonia are more likely to exhibit reduced alveolar diffusion capacity and exercise tolerance than men, despite a similar severity of the acute disease.
JOURNAL OF WOMENS HEALTH
(2023)
Review
Rheumatology
Dhivya Das et al.
Summary: Non-inflammatory pain is common in patients with inflammatory arthritis, and one important cause is concomitant fibromyalgia. Fibromyalgia is common in RA patients, affecting 1 in 5 patients, and is associated with higher disease activity scores. European Alliance of Association for Rheumatology highlights that concomitant fibromyalgia is an important consideration in assessing difficult-to-treat RA.
Article
Anesthesiology
Saman Haider et al.
Summary: An increasing number of individuals experience prolonged symptoms after having COVID-19, known as post-COVID-19 condition. This study aimed to compare the symptom profiles of individuals with post-COVID-19, fibromyalgia syndrome (FMS), and chronic fatigue syndrome (CFS). The study found that all three conditions had elevated levels of pain, fatigue, anxiety, depression, catastrophizing, and kinesiophobia. Physical and cognitive function were similarly affected in post-COVID-19, FMS, and CFS, but post-COVID-19 individuals reported lower levels of pain and fatigue compared to FMS and CFS. The comorbidity of post-COVID-19 with FMS and/or CFS worsened pain, fatigue, and psychological aspects. These findings suggest the importance of a biopsychosocial approach in managing post-COVID-19 symptoms.
Article
Anesthesiology
Cesar Fernandez-de-las-Penas et al.
Summary: This multicenter cohort study investigated the prevalence and risk factors of musculoskeletal post-COVID pain. The study found that musculoskeletal pain remains highly prevalent one year after hospitalization, with female sex, previous history of pain symptoms, pain symptoms at onset, and days at hospital being associated factors.
Article
Anesthesiology
Cesar Fernandez-de-las-Penas et al.
Summary: This study investigated the association between various variables and Central Sensitization Inventory (CSI) in previously hospitalized COVID-19 survivors experiencing post-COVID pain. The results showed that psychological and cognitive variables, such as anxiety levels and pain intensity, were independently associated with CSI scores. This suggests a significant overlap with psychological constructs and indicates important changes in pain processing for managing post-COVID pain.
Review
Clinical Neurology
Robert R. Edwards et al.
Summary: There is a large variability in individual response to pain treatments, even those that are highly effective, which has led to calls for personalized approaches to treating patients with pain. Precision pain medicine aims to determine the optimal treatments for specific patients by using empirically based algorithms. This review surveys the current state of precision pain medicine and presents evidence-based recommendations for its application in chronic pain research.
Article
Clinical Neurology
Ilona Merikanto et al.
Summary: An international survey study reveals that post-acute sequelae of COVID-19 symptoms are more prevalent among severe cases and long-lasting sleep problems are at the core of these symptoms. Understanding the importance of sleep-related symptoms has clinical relevance in diagnosing and treating long-COVID.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Medicine, Research & Experimental
Priya Kannan et al.
Summary: This study evaluated the effectiveness of physiotherapy interventions for peripheral neuropathic pain (pNeP) caused by various underlying conditions. The results showed that spinal cord stimulation was effective in treating pNeP secondary to failed back surgery syndrome and diabetic neuropathy. Laser therapy was more effective than sham laser for pain relief in carpal tunnel syndrome. The efficacy of acupuncture and electromagnetic therapy for chemotherapy-induced pain and diabetic neuropathy, respectively, remains inconclusive.
CONTEMPORARY CLINICAL TRIALS
(2023)
Article
Clinical Neurology
Peter Novak et al.
Summary: This study aimed to describe the cerebrovascular, neuropathic, and autonomic features of post-acute sequelae of COVID-19 (PASC). The study found that PASC is associated with multisystem abnormalities, including cerebrovascular dysregulation, small fiber neuropathy, and autonomic dysfunction, along with chronic inflammation.
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
David Garcia-Azorin et al.
Summary: The duration of headache during the acute phase of COVID-19 is 2 weeks, but approximately a fifth of patients experience persistent headache following a chronic daily pattern.
Review
Infectious Diseases
Mohamad Salim Alkodaymi et al.
Summary: This study aimed to estimate the prevalence of persistent symptoms and signs at least 12 weeks after acute COVID-19 and found that a large proportion of patients experience post-acute COVID-19 syndrome 3 to 12 months after recovery from the acute phase of COVID-19. However, available studies of post-acute COVID-19 syndrome are highly heterogeneous. Future studies need to have appropriate comparator groups, standardized symptom definitions and measurements, and longer follow-up.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Anesthesiology
Emel Oguz-Akarsu et al.
Summary: This study identified the main pain syndromes associated with the acute phase of mild-to-moderate COVID-19 and their characteristics. There are significant relationships between pain syndromes in COVID-19, which may be due to a sequence of common etiologic factors.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Anesthesiology
Afroditi Kouraki et al.
Summary: This study identified genetic markers associated with pain sensitization and neuropathic-like pain in osteoarthritis patients, which could be clinically important in early intervention.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Biochemistry & Molecular Biology
Natasja de Bruin et al.
Summary: The study found that ibuprofen, flurbiprofen, etoricoxib, and paracetamol have no effect on ACE2 expression and activity in vitro or in vivo. However, high concentrations of ibuprofen and flurbiprofen can reduce the replication of SARS-CoV-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Hawraa Kadhem Al-Jassas et al.
Summary: This study aims to investigate the associations between affective and chronic fatigue syndrome-like symptoms and chest CT scan anomalies, oxygen saturation, inflammatory biomarkers, etc. in COVID-19 patients. The results showed that the immune response core was associated with lung lesions and affective and physiosomatic symptoms. The infection-immune-inflammatory core plays a significant role in pneumonia-associated CT scan anomalies, decreased oxygen saturation, and immune activation, and it affects the affective and neuropsychiatric symptoms of patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Virology
Chihiro Tani-Sassa et al.
Summary: In the summer of 2021, the rapid spread of the Delta variant of the SARS-CoV-2 virus raised serious concerns globally. The Delta variant became the most prevalent in July and August, with infected patients in Tokyo being significantly younger, possibly due to vaccination of elderly individuals. Further research is needed to understand factors contributing to the increased infectivity of the Delta variant.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Virology
Abolfazl Adli et al.
Summary: COVID-19 cases exhibit significant variations in manifestation and severity among individuals of different ethnic backgrounds and geographical locations. Factors such as population density, gender and age differences, and comorbid conditions may contribute to the differences in disease presentation. Genetic factors are believed to influence susceptibility to SARS-CoV-2 infection and disease severity. Various genetic polymorphisms are found to affect virus pathogenicity and host immunity.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Nutrition & Dietetics
Kamila S. Batista et al.
Summary: This article discusses the adjunct role of vitamin B-12 in the treatment of viral infections and persistent symptoms of COVID-19, focusing on symptoms related to the muscle-gut-brain axis. Vitamin B-12 can help balance immune responses and improve resistance to viral infections.
Article
Anesthesiology
Muath A. Shraim et al.
Summary: This study used the Delphi expert consensus method to identify classification features and generated a list of candidate features that could aid in discrimination between types of musculoskeletal pain.
Review
Anesthesiology
Cesar Fernandez-de-las-Penas et al.
Summary: This review or meta-analysis aims to analyze the prevalence of musculoskeletal pain symptoms after COVID-19 infection among hospitalized or nonhospitalized patients. The analysis showed that nearly 10% of individuals infected with SARS-CoV-2 will experience musculoskeletal post-COVID pain symptoms during the first year after infection.
Article
Anesthesiology
Cesar Fernandez-de-las-Penas et al.
Summary: This study investigated the prevalence and risk factors of long-term musculoskeletal post-COVID pain in COVID-19 survivors. The study found that 45.1% of survivors experienced musculoskeletal post-COVID pain 8 months after hospital discharge, and risk factors included female sex, history of musculoskeletal pain, presence of myalgia and headache as COVID-19 symptoms, and days at hospital.
Article
Orthopedics
Rosie Twomey et al.
Summary: This study evaluated the severity of fatigue and postexertional malaise in people living with long COVID. The findings suggest that long COVID is characterized by clinically relevant chronic fatigue and significant challenges related to postexertional symptom exacerbation. It is important to monitor and report these symptoms in clinical practice and interventions for people with long COVID.
Article
Environmental Sciences
Amir Hossein Ahmadi Hekmatikar et al.
Summary: This study evaluated the effect of resistance or aerobic exercises in post-COVID-19 patients after hospital discharge. The findings suggest that exercise programs may improve functional capacity, quality of life, and reduce stress and mental disorders in these patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Microbiology
Qing Han et al.
Summary: Emerging evidence suggests that COVID-19 survivors may experience persistent symptoms for at least 12 months, including fatigue, dyspnea, arthromyalgia, depression, anxiety, memory loss, concentration difficulties, and insomnia. Female patients and those with more severe initial illness are more likely to suffer from long-term sequelae after one year.
Review
Medicine, General & Internal
Huan Chen et al.
Summary: Pulmonary rehabilitation (PR) can improve exercise capacity for patients with mild-to-moderate lung impairment after COVID-19, as indicated by the 6-minute walk test results. However, the effects on lung function and quality of life are inconsistent across studies, highlighting the need for more research in this area.
FRONTIERS IN MEDICINE
(2022)
Article
Rehabilitation
Sarita Santos et al.
Summary: This case study describes the use of musculoskeletal physiotherapy in a post-COVID-19 adult woman to resume her daily physical activities. The therapy resulted in reduced pain, increased muscle strength, expanded joint ranges, and improved balance. The use of quantitative measurements to evaluate progress proved to be valuable in the recovery of patients with musculoskeletal sequelae from COVID-19.
PHYSIOTHERAPY RESEARCH INTERNATIONAL
(2022)
Review
Clinical Neurology
Pedro Augusto Sampaio Rocha-Filho
Summary: This review discusses the epidemiology, pathophysiology, characteristics, and management of COVID-19-associated headache. Headache is a common clinical symptom of COVID-19, affecting over half of the patients, especially young patients and those with a history of previous headaches. The headache usually occurs early in the symptomatic phase and has similar characteristics to tension-type headaches. The possible pathophysiological mechanisms include viral injury, inflammatory processes, and other mechanisms. Commonly used drugs for treatment include analgesics and nonsteroidal anti-inflammatory drugs.
Article
Medicine, General & Internal
Manuel Herrero-Montes et al.
Summary: This study investigated the prevalence of neuropathic pain symptoms in COVID-19 survivors with de novo post-COVID pain and analyzed the correlation between these symptoms and pain-related, psychological, and cognitive variables. The findings showed that almost 25% of previously hospitalized COVID-19 survivors reported neuropathic pain symptoms, and these symptoms were associated with higher levels of anxiety and kinesiophobia.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Review
Immunology
Chen Chen et al.
Summary: This study reveals a substantial prevalence of post-COVID-19 condition worldwide. Hospitalized patients have a higher prevalence compared to non-hospitalized ones. Fatigue is the most commonly reported symptom.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Virology
Rossella Fonnesu et al.
Summary: Lipids play a crucial role in viral entry and replication, and disrupted lipid metabolism can lead to the production of inflammatory stimuli. Palmitoylethanolamide (PEA) has been found to counteract SARS-CoV-2 through binding to its S protein and dismantling lipid droplets.
Review
Medicine, General & Internal
Gaia Cattadori et al.
Summary: Rehabilitation centers have become major players in the battle against COVID-19, as many patients continue to suffer from long-COVID-19 syndrome. Exercise training has beneficial effects on the immune system and inflammation, leading the authors to propose a post-COVID-19 patient exercise protocol that combines multiple recommended exercise training regimens.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Giuseppe Maglietta et al.
Summary: This study investigates the association between factors present during COVID-19 hospitalization and long-term sequelae. The findings suggest that female sex and acute disease severity may serve as independent prognostic factors. Further longitudinal studies with longer follow-up are needed to confirm these results and develop targeted prevention and management strategies for individuals at higher risk for PCS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Dan Cui et al.
Summary: This study investigated the proportions, characteristics, and risk factors of rheumatic symptoms following COVID-19. The study found that 12.3% of discharged patients experienced these symptoms at 12-month follow-up, with the knee joints being the most frequently affected. Rheumatic symptoms were independent of disease severity and corticosteroid treatment during the acute phase, but older age and female sex were identified as risk factors.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Anne Louise Oaklander et al.
Summary: This study analyzed the neuropathy conditions in patients with long COVID and found that small-fiber neuropathy after mild SARS-CoV-2 infection was the most common, with difficulties in treatment.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Neurosciences
Sara Nowakowski et al.
Summary: A growing body of research has found that physical and neuropsychiatric symptoms may persist following acute COVID-19 infection. This study examined the relationship between insomnia and mental health and found a significant association between poor sleep quality and increased severity of depression, anxiety, and post-traumatic stress. Future research should consider long-term follow-up of patients to determine if sleep, fatigue, and mental health symptoms improve over time.
Review
Biochemistry & Molecular Biology
Alfredo Cordova-Martinez et al.
Summary: The article reviews peripheral neuropathies and their treatment methods, focusing on the use of nutraceutical strategies to improve neuropathy symptoms in COVID-19 patients. Nutrients may play a key role in COVID-19 treatment, but can also lead to neuropathy.
Review
Clinical Neurology
Jeremy R. Chang et al.
Summary: This systematic review and meta-analysis examined the effects of different experimental sleep deprivation paradigms on pain outcomes. The results showed that total sleep deprivation significantly reduced pain threshold and tolerance in healthy individuals, while partial sleep deprivation increased spontaneous pain intensity. Sleep fragmentation was found to increase peripheral and central sensitization in healthy individuals. The effects of sleep deprivation on pain outcomes in individuals with chronic pain were uncertain. Further research is needed to better understand these relationships.
SLEEP MEDICINE REVIEWS
(2022)
Review
Virology
Diego Fernandez-Lazaro et al.
Summary: COVID-19 survivors often experience physical weakness, respiratory function impairment, and decreased quality of life due to persistent symptoms and post-acute consequences of SARS-CoV-2 infection. This study reviews the effect of therapeutic exercise strategies (ThEx) in reversing these negative effects caused by post-COVID-19 syndrome. The findings suggest that ThEx interventions can improve strength, respiratory function, physical fitness, and quality of life in patients with post-COVID-19 syndrome, with no exercise-related side effects.
Review
Virology
Cesar Fernandez-de-las-Penas et al.
Summary: This study compared the prevalence of long-COVID symptoms according to relevant SARS-CoV-2 variants in COVID-19 survivors, finding that individuals infected with the historical variant are more likely to develop long-COVID symptomatology, while patients infected with the Omicron variant have the lowest prevalence of long-COVID symptoms.
Review
Environmental Sciences
Min Du et al.
Summary: Although many studies have been conducted on long COVID-19, the differences caused by different SARS-CoV-2 strains have not been systematically studied. This systematic review and meta-analysis evaluated the characteristics of long COVID-19 caused by different strains. The findings suggest that there is no significant difference between long COVID-19 caused by different strains, except for certain general symptoms and sleep difficulty. It is important to pay attention to long COVID-19 caused by unique strains and implement targeted intervention measures.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Medicine, General & Internal
Kin Israel Notarte et al.
Summary: This systematic literature review and meta-analysis aimed to identify risk factors for the development of long COVID-19. The study found that advancing age was not associated with long COVID-19, but female sex was a risk factor. Additionally, medical comorbidities such as pulmonary disease, diabetes, obesity, and organ transplantation were also identified as potential risk factors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Cesar Fernandez-de-Las-Penas et al.
Summary: This study explores the complex associations between sensory-related, psychological, and cognitive variables in post-COVID pain among previously hospitalized COVID-19 survivors. The findings suggest that post-COVID pain is significantly associated with depressive symptoms, anxiety levels, and neuropathic pain features. The study also highlights the impact of gender on neuropathic pain symptoms, with females reporting more severe symptoms than males. Additionally, higher levels of depressive symptoms are linked to worse sleep quality and greater catastrophizing.
Review
Environmental Sciences
Melina Bailly et al.
Summary: This research systematically reviewed the effects of physical activity programs on the recovery of post-COVID-19 patients. The study found that regardless of exercise modalities, rehabilitation including physical activity had clear health benefits in post-COVID-19 recovery. Most of the studies were retrospective, uncontrolled, and enrolled aged people with comorbidities presented in severe forms of COVID-19. Prospective well-designed studies specifically assessing the effects of physical activity are needed to further validate the promising results.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Genetics & Heredity
Cesar Fernandez-de-las-Penas et al.
Summary: This study investigated the association between selected pain polymorphisms and long-COVID pain symptoms in COVID-19 survivors, as well as their association with clinical, sensory-related, cognitive, and psychological variables. The results suggest that these pain polymorphisms may not predispose individuals to the development or characteristics of long-COVID pain symptoms.
Review
Clinical Neurology
Omar Khoja et al.
Summary: This review discusses the features and characteristics of musculoskeletal (MSK) pain in Long COVID patients. Understanding of the prevalence, characteristics, and underlying mechanisms of MSK pain in Long COVID is currently limited. MSK pain in Long COVID can be localized or widespread, with no clear progression pattern over time. Female gender and higher BMI may be potential risk factors for MSK pain, but age and ethnicity do not have a clear association. Several pathophysiological mechanisms, including increased production of proinflammatory cytokines, immune cell hyperactivation, direct viral entry into neurological and MSK system cells, and psychological factors, have been hypothesized to contribute to MSK pain in Long COVID.
JOURNAL OF PAIN RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Damiana Scuteri et al.
Summary: Around 30-50% of the global population and nearly 20% of the European population suffer from chronic pain, which poses a significant burden to society. While preclinical studies have shown that Palmitoylethanolamide (PEA) can improve pain, there is still a lack of clinical evidence. This study aimed to evaluate the efficacy of PEA for musculoskeletal and neuropathic pain in a clinical setting. The results of the analysis on 933 patients demonstrated that PEA was more effective than the control group in reducing pain. However, the high heterogeneity of the studies and potential publication bias downgrade the results. The study also reported the efficacy of PEA in reducing the need for rescue medications and improving functioning, neuropathic symptoms, and quality of life. Further randomized, double-blind clinical trials with larger sample sizes are needed to investigate the efficacy of PEA as an add-on therapy for chronic pain.
Article
Biochemistry & Molecular Biology
Cesar Fernandez-de-las-Penas et al.
Summary: This study compared the prevalence of musculoskeletal post-COVID pain in COVID-19 survivors infected with different SARS-CoV-2 variants. The findings showed that patients infected with the historical variant had the highest prevalence of musculoskeletal pain, with generalized pain symptoms being most common.
Article
Neurosciences
Lara Diem et al.
Summary: This study investigated post-COVID-19 syndrome and found that fatigue, pain, and sleep-wake disturbances were the main symptoms, impacting the quality of life and work ability of the majority of patients. Survey respondents reported significant reduction in symptoms over 12 months.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Sarah Wulf Hanson et al.
Summary: This study estimated the proportion and duration of Long COVID symptoms in individuals with symptomatic SARS-CoV-2 infection in 2020 and 2021. The results showed differences in the prevalence and duration of Long COVID symptoms across different age and gender groups.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Multidisciplinary Sciences
Jennifer A. Frontera et al.
Summary: This study identified three clinically relevant phenotypes of post-acute sequelae of COVID-19 (PASC), which received different therapeutic interventions and had varying response rates. These findings can aid in the development of personalized treatment plans.
Article
Medicine, General & Internal
Raphael S. Peter et al.
Summary: This study describes the symptoms and symptom clusters of post-covid syndrome six to 12 months after acute infection, and examines the association of symptom clusters with general health and working capacity. The results suggest that fatigue and neurocognitive impairment contribute the most to reduced health recovery and working capacity, but other symptoms such as chest symptoms, anxiety/depression, headache/dizziness, and pain syndromes are also prevalent and relevant to working capacity.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Genetics & Heredity
Cesar Fernandez-de-las-Penas et al.
Summary: This study investigated the association between four polymorphisms of ACE2 and TMPRSS2 genes and long-COVID symptoms in COVID-19 survivors. The results showed no correlation between these gene polymorphisms and the development of long-COVID symptoms.
Article
Medicine, General & Internal
Panagiotis Zis et al.
Summary: This study found that chronic pain, especially neuropathic pain, is widely prevalent in COVID-19 survivors. The most common sites of pain are the low back and joints. Age and gender are predictors of chronic pain, while headache during COVID-19 is associated with neuropathic pain.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Cesar Fernandez-de-Las-Penas et al.
Summary: The study aimed to assess the association between four inflammatory polymorphisms and post-COVID pain, as well as their association with the clinical pain phenotype in previously hospitalized COVID-19 survivors. The results showed no significant association between these genetic polymorphisms and post-COVID pain, as well as no significant differences in the clinical pain phenotype between patients with and without post-COVID pain.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Pilar Carrasco-Garrido et al.
Summary: Psychotropic drug consumption has increased during the COVID-19 pandemic. This study examines the prevalence and factors associated with Benzodiazepine (BZD) and Z-hypnotics use among Spanish adults with long-COVID-19 syndrome, focusing on gender differences. The results show that the prevalence of BZD and Z-hypnotics use in this population is 44.9%, with higher rates among women. Age and medication use are predictive factors for BZD and Z-hypnotics use in men, while smoking habit and the number of post-COVID symptoms are predictive variables in women.
FRONTIERS IN MEDICINE
(2022)
Article
Neurosciences
Juan C. Pacho-Hernandez et al.
Summary: This study aimed to explore the relationship between biological and emotional variables associated with health-related quality of life in individuals with long-COVID. The results showed that sensitization-associated symptoms and mood disorders directly affected health-related quality of life, but these effects were not statistically significant when sleep quality was included. In fact, sleep quality mediated the relationship between sensitization-associated symptoms and mood disorders with health-related quality of life.
Article
Public, Environmental & Occupational Health
Maarten Moens et al.
Summary: The quality of life of post-COVID-19 infected persons is severely impacted, with symptoms of pain, fatigue, and limitations in daily activities. Their quality of life is lower compared to the general population and patients with chronic pain, but better compared to patients with chronic pain after spinal surgery.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Cesar Fernandez-de-las-Penas et al.
Summary: Pain after COVID-19 infection has become a healthcare emergency. Precision medicine can group patients based on their symptoms and diagnosis for tailored treatments. There are different types of pain after COVID-19, each requiring different treatment approaches. Classifying patients into different pain types is crucial for successful treatment outcomes.
Article
Pathology
Natalia Gavrilova et al.
Summary: This article explores the definition of fibromyalgia and the lack of understanding of its etiology and pathophysiology, pointing out the need to reconsider the causes of the disease development in patients after COVID-19. Through clinical case studies, a common combination of symptoms was identified, suggesting a potential link between fibromyalgia development and factors such as joint hypermobility and COVID-19.
Review
Medicine, General & Internal
Rubina Mulchandani et al.
Summary: Studies have shown significantly elevated levels of pro-inflammatory cytokines and reduced T lymphocytes in severe COVID-19 cases. However, there is heterogeneity across studies due to small sample sizes, nonuniform outcome assessment, and varied definitions of disease severity, indicating a need for well-designed and adequately powered prospective studies for more definitive answers.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Anesthesiology
Katherinne Ferro Moura Franco et al.
Summary: This study compared different exercise prescriptions for patients with chronic pain, focusing on fibromyalgia, chronic whiplash-associated disorders (CWAD), and chronic idiopathic neck pain (CINP). The results showed that for fibromyalgia, aerobic strengthening exercises were most effective, while for CWAD, body awareness exercises were similar to combined exercises. In CINP cases, motor control exercises and nonspecific muscle strengthening had a similar effect.
EUROPEAN JOURNAL OF PAIN
(2021)
Article
Anesthesiology
Felipe Henriques Carvalho Soares et al.
Summary: COVID-19 patients have significantly higher prevalence of de novo CP, chronic daily headache, and new-onset pain in general, which is associated with persistent anosmia.
EUROPEAN JOURNAL OF PAIN
(2021)
Article
Cell Biology
Ana M. Moreno et al.
Summary: This study demonstrated successful targeted repression of Nav1.7 in mouse pain models through epigenome engineering approaches, leading to significant reduction in thermal hyperalgesia in inflammatory states and tactile allodynia in neuropathic pain without affecting normal motor function. The long-lasting analgesia achieved through this in vivo epigenetic repression of Nav1.7 methodology, named pain LATER, holds therapeutic potential in management of persistent pain states.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Editorial Material
Medicine, General & Internal
Andreia Costa et al.
ACTA MEDICA PORTUGUESA
(2021)
Article
Psychiatry
Hugo Bottemanne et al.
Summary: Contrary to anxiety, depression after an acute COVID-19 episode may be associated with an increased risk of some persistent physical symptoms, including pain and dyspnea.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Lisa Goudman et al.
Summary: The study found that over 70% of patients post COVID-19 infection exhibit symptoms of central sensitisation, suggesting the need for patient education and multimodal rehabilitation to address nociplastic pain.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Yong-Hui Zhang et al.
Summary: Exercise is an effective alternative treatment or complementary therapy for neuropathic pain, with recommendations including muscle stretching, strengthening/resistance exercise, aerobic exercise, motor control/stabilization training, and mind-body exercises like Tai Chi and yoga. Regular updates are needed for the consensus statement every five to ten years.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Lawrence D. Hayes et al.
Summary: With the spread of the COVID-19 pandemic, more and more attention has been drawn to the persistent symptoms of long COVID, yet systematic reviews on the type and prevalence of symptoms are lacking. A study found that there are over 100 different symptoms reported in long COVID patients, with significant variations in prevalence, potentially related to unknown factors.
FRONTIERS IN MEDICINE
(2021)
Article
Nutrition & Dietetics
Luciele Guerra Minuzzi et al.
Summary: The study showed that BDNF levels can predict the need for intensive care in COVID-19 patients, particularly in those over 60 years of age. Leptin and adiponectin concentrations were not associated with patient outcomes, while the BDNF/adiponectin ratio was closely linked to worsened prognosis.
FRONTIERS IN NUTRITION
(2021)
Article
Anesthesiology
Cesar Fernandez-de-las-Penas et al.
Summary: This study found an association between COVID-related myalgia at hospital admission and musculoskeletal pain as long-term post-COVID sequelae. Additionally, fifty percent of patients with preexisting musculoskeletal pain experienced a worsening of symptoms after COVID-19.
Review
Anesthesiology
Eva Kosek et al.
Review
Psychiatry
Peter A. Hall et al.
Summary: The review highlights the importance of understanding the interaction between biological and behavioral factors with societal processes during the COVID-19 pandemic. It emphasizes the need for empirical research to examine mechanistic pathways from infection to outcomes, and for insights on how emotional and behavioral factors contribute to and are impacted by the pandemic.
PSYCHOSOMATIC MEDICINE
(2021)
Review
Environmental Sciences
Amaya Jimeno-Almazan et al.
Summary: Post-COVID-19 syndrome poses a serious challenge, with patients potentially experiencing effects of the disease beyond 12 weeks. While there are concerns about diagnostic identification, regular exercise can help improve many symptoms and reduce the long-term effects of COVID-19.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Clinical Neurology
Cesar Fernandez-de-las-Penas et al.
Summary: The study found that headache during the acute phase of SARS-CoV-2 infection was associated with long-term post-COVID headache and other symptoms, such as fatigue. Patients with headache at onset had a higher prevalence of post-COVID symptoms, including headache and fatigue. Monitoring headache during the acute phase could help identify patients at risk of developing long-term post-COVID symptoms.
Review
Medicine, General & Internal
Cesar Fernandez-de-las-Penas et al.
Summary: This meta-analysis revealed that more than 60% of patients with SARS-CoV-2 infection experienced post-COVID-19 symptoms. Fatigue and dyspnea were the most prevalent post-COVID-19 symptoms, especially at 60 and >= 90 days after onset.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Clinical Neurology
Cesar Fernandez-de-las-Penas et al.
Summary: This study analyzed the prevalence of post-COVID headache in COVID-19 survivors, finding that the prevalence of headache was around 47.1% at onset or hospital admission, 10.2% at 30 days, 16.5% at 60 days, 10.6% at 90 days, and 8.4% at >=180 days. Headache as a symptom at the acute phase was more prevalent in non-hospitalized patients compared to hospitalized patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Medicine, General & Internal
Fulya Bakilan et al.
Summary: This study aimed to evaluate the musculoskeletal symptoms and related factors in postacute COVID-19 patients. The most common symptoms were fatigue, spine pain, and myalgia, with back pain being the most frequent pain region. Factors such as chronic diseases, duration of hospital stay, back pain during acute COVID-19, CT findings, and d-dimer levels were associated with post-COVID-19 musculoskeletal symptoms.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Review
Biochemistry & Molecular Biology
Angel Yun-Kuan Thye et al.
Summary: The battle against the SARS-CoV-2 virus continues globally, with various clinically significant variants emerging, including Alpha, Beta, Delta, and Gamma. These variants possess key mutations on the spike protein, which contribute to increased transmissibility and evasion of the host immune response, leading to detrimental effects on public health.
Review
Anesthesiology
Muath A. Shraim et al.
Summary: Mechanism-based classification of pain is advocated to tailor interventions for persistent musculoskeletal pain. However, discrimination between nociceptive, neuropathic, and nociplastic pain categories remains challenging. Few validated methods exist, with recommendations for a combination of features and methods for discrimination.
Review
Medicine, General & Internal
Fahad M. Iqbal et al.
Summary: This study aimed to investigate the prevalence of clinical characteristics of acute and chronic post-COVID syndrome, finding that fatigue and dyspnoea were the most prevalent symptoms in acute stage, while fatigue and sleep disturbance were the most prevalent symptoms in chronic stage. However, the overall quality of available evidence is poor, with significant risk of bias.
Review
Psychiatry
Peter A. Hall et al.
Summary: The review highlights the impact of the COVID-19 pandemic in terms of biological, behavioral, and societal processes globally. Factors such as affective, cognitive, behavioral, socioeconomic, and technological factors play significant roles in the spread of infection and outcomes of mitigation efforts. The pandemic emphasizes the importance of understanding the interaction between biological, behavioral, and societal factors in managing infectious diseases.
PSYCHOSOMATIC MEDICINE
(2021)
Review
Rheumatology
Jo Nijs et al.
Summary: Chronic pain is a major cause of disability and high healthcare costs globally. Central sensitisation, amplification of neural signalling in the CNS leading to pain hypersensitivity, has been investigated as a reason for discrepancy between tissue damage extent and pain severity. Central sensitisation varies among patients with different pain conditions, predicting poor treatment outcomes and suggesting the importance of individual assessment and treatment strategies.
LANCET RHEUMATOLOGY
(2021)
Review
Anesthesiology
Alberto Arribas-Romano et al.
Review
Immunology
Daniel Aletaha
JOURNAL OF AUTOIMMUNITY
(2020)
Review
Virology
Eric A. Coomes et al.
REVIEWS IN MEDICAL VIROLOGY
(2020)
Article
Medicine, General & Internal
Ravi P. Rajkumar
CUREUS JOURNAL OF MEDICAL SCIENCE
(2020)
Review
Anesthesiology
Sarah E. E. Mills et al.
BRITISH JOURNAL OF ANAESTHESIA
(2019)
Review
Pharmacology & Pharmacy
Jo Nijs et al.
EXPERT OPINION ON PHARMACOTHERAPY
(2019)
Review
Immunology
Ruizhe Wang et al.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2019)
Review
Anesthesiology
Joachim Scholz et al.
Review
Obstetrics & Gynecology
Laura H. Goetz et al.
FERTILITY AND STERILITY
(2018)
Letter
Anesthesiology
Murat Aydede et al.
Article
Orthopedics
Jo Nijs et al.
Review
Neurosciences
Meggane Melchior et al.
Review
Neurosciences
Katerina Zorina-Lichtenwalter et al.
Review
Anesthesiology
Eva Kosek et al.
Review
Clinical Neurology
Patrick H. Finan et al.
Article
Anesthesiology
Ellen L. Terry et al.
Review
Biotechnology & Applied Microbiology
Anne Tammimaki et al.
PHARMACOGENETICS AND GENOMICS
(2012)
Article
Orthopedics
Steven Z. George et al.
Review
Anesthesiology
Clifford J. Woolf
Article
Rehabilitation
Keith M. Smart et al.
Article
Anesthesiology
YH Chiu et al.
