Modular Synthesis of Phosphite and Phosphoramidite Ligands for Rh-Catalyzed Hydroformylation

Rhodium-catalyzed hydroformylation of olefins is an important method for synthesizing aldehydes, and it is worth noting that regioselectivity and enantioselectivity of the product controlled by ligand are the most commonly used strategies. The modular synthesis of phosphite and phosphoramidite ligands have significant advantages of simple synthesis and high catalytic activity, which was why these ligands have been widely used in hydroformylation reactions. Herein, we focus on the synthesis methods and design ideas of such ligands, as well as their application effects in hydroformylation reactions. This review aims to provide a reference for the design and synthesis of ligands in hydroformylation subsequently.

Automated summary

Rhodium-catalyzed hydroformylation of olefins is a significant method for synthesizing aldehydes, and the regioselectivity and enantioselectivity of the product controlled by ligands are commonly used strategies. The modular synthesis of phosphite and phosphoramidite ligands has advantages of simple synthesis and high catalytic activity, thus being widely used in hydroformylation reactions. This review focuses on the synthesis methods and design ideas of such ligands, as well as their application effects in hydroformylation reactions, aiming to provide a reference for ligand design and synthesis in subsequent hydroformylation.