4.5 Article

Construction of Difluoroalkylated Cyclopentenones through Photocatalytic Difluoroalkylative 5-endo Cyclization Cascades of Ynones

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WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202300432

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radical; difluoroalkylation; cyclopentenone; photocatalysis; 5-endo cyclization

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In this article, a visible-light-induced cascade difluoroalkylative 5-endo cyclization of ynones with difluoroalkyl bromides is reported, leading to the formation of difluoroalkylated cyclopentenones. This method offers a concise synthesis of fluorinated cyclic molecules and shows potential for wide applications.
Difluoroalkyl groups and cyclopentenones are both important units in synthetic and medicinal chemistry. The difuoroalkylation coupled with a cyclopentenone formation still remains a challenge. Herein, we report a visible-light-induced cascade difluoroalkylative 5-endo cyclization of ynones with difluoroalkyl bromides to access difluoroalkylated cyclopentenones, which may find wide applications for the concise synthesis of fluorinated cyclic molecules.

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