期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 26, 期 14, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202300056
关键词
1; 4-enyne; alkynylation; alkynyl copper reagents; allylic phosphates; regioselective reaction
We developed a method for the alkynylation of allylic phosphates with acetylenes in the presence of copper and magnesium salts. The reaction showed regioselectivity to produce corresponding 1,4-enynes. The reaction also exhibited good tolerance towards functional groups. As an application, the synthesis of 1,4-enyne intermediate for 13R,19S,20S-trihydroxydocosapentaenoic acid was efficiently achieved.
We developed an alkynylation of allylic phosphates with acetylenes in the presence of copper and magnesium salts. The reaction proceeded regioselectively to afford the corresponding 1,4-enynes. Furthermore, the functional group tolerance of this reaction was established. As an application, the 1,4-enyne intermediate involved in the synthesis of 13R,19S,20S-trihydroxydocosapentaenoic acid could be efficiently synthesized.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据