4.5 Article

Rhodium-Catalyzed C8-Alkenylation of Isoquinolones with Maleimides

期刊

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202300411

关键词

C-H activation; alkenylation; isoquinolone; maleimide; rhodium

向作者/读者索取更多资源

An efficient Rh(III)-catalyzed C-H alkenylation of N-protected isoquinolone with maleimides is demonstrated, where the carbonyl group of isoquinolone acts as an inherent directing group. Various N-substituents in the maleimide, including alkyl, aryl, and even H and -OH, were well tolerated. This protocol exhibits broad substrate scope, good selectivity, and excellent yields, with the effect of substituents on the reaction progress confirmed by Hammett plot.
An efficient Rh(III)-catalyzed C-H alkenylation of N-protected isoquinolone with maleimides is reported. The carbonyl group of isoquinolone acts as an inherent directing group. Various N-substituents in the maleimide, including alkyl, aryl, and even H and -OH, were well tolerated under the developed reaction condition. This protocol showed broad substrate scope, good selectivity, and excellent yields. Hammett plot is also drawn to check the effect of substituents on the reaction progress.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据