期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 252, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2023.115330
关键词
Marine microorganisms; Anti; Vibrio activity; Natural products; Structural diversity; Structure-activity relationship
The emergence of drug-resistant Vibrio poses a serious threat to aquaculture and human health. Therefore, there is a need to discover new antibiotics related to this. Marine microorganisms have been identified as important sources of antibacterial natural products, and a review of 214 anti-Vibrio natural products isolated from marine microorganisms is presented in this study. These compounds, including 108 new ones, show great structural diversity and have potential applications in agriculture and human health.
The emergence of drug-resistant Vibrio poses a serious threat to aquaculture and human health, thus there is an urgent need for the discovery of new related antibiotics. Given that marine microorganisms (MMs) are evidenced as important sources of antibacterial natural products (NPs), great attention has been gained to the exploration of potential anti-Vibrio agents from MMs. This review summarizes the occurrence, structural diversity, and biological activities of 214 anti-Vibrio NPs isolated from MMs (from 1999 to July 2022), including 108 new compounds. They were predominantly originated from marine fungi (63%) and bacteria (30%) with great structural diversity, including polyketides, nitrogenous compounds, terpenoids, and steroids, among which polyketides account for nearly half (51%) of them. This review will shed light on the development of MMs derived NPs as potential anti-Vibrio lead compounds with promising applications in agriculture and human health.
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