相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Targeting trypanosomes: how chemogenomics and artificial intelligence can guide drug discovery
Lionel Uran Landaburu et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2023)
A profile of research on the parasitic trypanosomatids and the diseases they cause
David Horn
PLoS Neglected Tropical Diseases (2022)
Review of the neglected tropical diseases programme implementation during 2012-2019 in the WHO-Eastern Mediterranean Region
Supriya Warusavithana et al.
PLOS NEGLECTED TROPICAL DISEASES (2022)
Proteomics of Select Neglected Tropical Diseases
Anthony J. Saviola et al.
Annual Review of Analytical Chemistry (2020)
Chagas Disease: Current View of an Ancient and Global Chemotherapy Challenge
Javier Martin-Escolano et al.
ACS INFECTIOUS DISEASES (2020)
Insight into the factors controlling the equilibrium of allylic azides
Margarita M. Vallejos et al.
RSC ADVANCES (2020)
Sterol methyltransferase is required for optimal mitochondrial function and virulence in Leishmania major
Sumit Mukherjee et al.
MOLECULAR MICROBIOLOGY (2019)
Malaria eradication within a generation: ambitious, achievable, and necessary
Richard G. A. Feachem et al.
LANCET (2019)
Discovery and Genetic Validation of Chemotherapeutic Targets for Chagas' Disease
Juan Felipe Osorio-Mendez et al.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)
Repositioning Salirasib as a new antimalarial agent
Exequiel O. J. Porta et al.
MEDCHEMCOMM (2019)
Synthesis and Biological Activity of Sterol 14-Demethylase and Sterol C24-Methyltransferase Inhibitors
David J. Leaver
MOLECULES (2018)
Neglected tropical diseases: progress towards addressing the chronic pandemic
David H. Molyneux et al.
LANCET (2017)
Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles
Exequiel O. J. Porta et al.
MEDCHEMCOMM (2017)
Experimental and theoretical studies of the [3,3]-sigmatropic rearrangement of prenyl azides
Exequiel O. J. Porta et al.
RSC ADVANCES (2017)
Human African trypanosomiasis control: Achievements and challenges
Serap Aksoy et al.
PLOS NEGLECTED TROPICAL DISEASES (2017)
The francophone network on neglected tropical diseases
Jean Jannin et al.
PLOS NEGLECTED TROPICAL DISEASES (2017)
Mortality and socioeconomic status: the vicious cycle between poverty and ill health
Victoria Pillay-van Wyk et al.
LANCET GLOBAL HEALTH (2017)
A CRISPR Cas9 high-throughput genome editing toolkit for kinetoplastids
Tom Beneke et al.
ROYAL SOCIETY OPEN SCIENCE (2017)
Optimized CRISPR-Cas9 Genome Editing for Leishmania and Its Use To Target a Multigene Family, Induce Chromosomal Translocation, and Study DNA Break Repair Mechanisms
Wen-Wei Zhang et al.
MSPHERE (2017)
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
Antoine Daina et al.
SCIENTIFIC REPORTS (2017)
Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum
Blanca Colin-Lozano et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer
Zongtao Lin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Sterol Biosynthesis Pathway as an Alternative for the Anti-Protozoan Parasite Chemotherapy
Sara Teixeira de Macedo-Silva et al.
CURRENT MEDICINAL CHEMISTRY (2015)
Data Warrior: An Open-Source Program For Chemistry Aware Data Visualization And Analysis
Thomas Sander et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2015)
pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures
Douglas E. V. Pires et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Hit and lead criteria in drug discovery for infectious diseases of the developing world
Kei Katsuno et al.
NATURE REVIEWS DRUG DISCOVERY (2015)
Click chemistry decoration of amino sterols as promising strategy to developed new leishmanicidal drugs
Exequiel O. J. Porta et al.
STEROIDS (2014)
CoMFA studies and in vitro evaluation of some 3-substituted benzylthio quinolinium salts as anticryptococcal agents
Sidney Bolden et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Demystifying Brain Penetration in Central Nervous System Drug Discovery
Li Di et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents
Federica Gigante et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Δ24(25)-sterol methenyltransferase:: Intracellular localization and azasterol sensitivity in Leishmania major promastigotes over expressing the enzyme
Carmen Jimenez-Jimenez et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2008)
Evaluation of azasterols as anti-parasitics
Ludovic Gros et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in Trypanosoma brucei
WX Zhou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Enzyme redesign and interactions of substrate analogues with sterol methyltransferase to understand phytosterol diversity, reaction mechanism and the nature of the active site
WD Nes
BIOCHEMICAL SOCIETY TRANSACTIONS (2005)
Synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphoric acid analogues as alternate substrates for methylerythritol phosphate synthase
DT Fox et al.
JOURNAL OF ORGANIC CHEMISTRY (2005)
New aminocyclitols as modulators of glucosylceramide metabolism
M Egido-Gabas et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2005)
Azasterols as inhibitors of sterol 24-methyltransferase in leishmania species and Trypanosoma cruzi
F Magaraci et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Sterol methyl transferase: enzymology and inhibition
WD Nes
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2000)
Antimalarial, antitrypanosomal, and antileishmanial activities and cytotoxicity of bis(9-amino-6-chloro-2-methoxyacridines):: Influence of the linker
S Girault et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
分享论文
