Incidence of myocarditis and pericarditis considered as separate clinical events over the years and post-SARS-CoV2 vaccination in adults and children

Article Pharmacology & Pharmacy

Myocarditis and pericarditis associated with SARS-CoV-2 vaccines: A population-based descriptive cohort and a nested self-controlled risk interval study using electronic health care data from four European countries

Sophie H. H. Bots et al.

Summary: This study found that mRNA-based COVID-19 vaccines and potentially AstraZeneca are associated with increased myocarditis risk in younger individuals, although the absolute incidence remains low. More data on children (≤11 years) are needed.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Medicine, General & Internal

Postmarketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12 to 39 years in Italy: A multi-database, self-controlled case series study

Marco Massari et al.

Summary: This study in Italy found an association between myocarditis/pericarditis and the mRNA vaccines BNT162b2 and mRNA-1273 in individuals aged 12 to 39. The highest risks were observed in males aged 12 to 39 and in males and females aged 18 to 29 vaccinated with mRNA-1273. The findings should be considered in the context of mRNA vaccine effectiveness against severe COVID-19 disease and death.

PLOS MEDICINE (2022)

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Review Cardiac & Cardiovascular Systems

Myocarditis in SARS-CoV-2 infection vs. COVID-19 vaccination: A systematic review and meta-analysis

Navya Voleti et al.

Summary: This study compared the incidence of myocarditis between COVID-19 vaccine recipients and individuals infected with SARS-CoV-2. The results showed that the risk of myocarditis was over seven times higher in the infection group compared to the vaccination group. Male and younger populations had a higher risk of myocarditis, and the incidence of myocarditis decreased gradually over time after vaccination.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Infectious Diseases

Increased risk of myocarditis and pericarditis and reduced likelihood of severe clinical outcomes associated with COVID-19 vaccination: a cohort study in Lombardy, Italy

Giovanni Corrao et al.

Summary: This study assessed the harms and benefits of COVID-19 vaccination. The results showed that the risk of myocarditis was highest among 16 to 19-year-old men who received the Moderna vaccine. The balance between harms and benefits was mostly favorable for other subgroups.

BMC INFECTIOUS DISEASES (2022)

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Article Cardiac & Cardiovascular Systems

Effusive-constrictive pericarditis after the second dose of BNT162b2 vaccine (Comirnaty): a case report

Giacomo Maria Viani et al.

Summary: This case report describes a patient who developed effusive-constrictive pericarditis (ECP) shortly after receiving the second dose of the BNT162b2 vaccine. No previous cases of ECP related to the SARS-CoV2 vaccine have been documented. Treatment according to guidelines resulted in clinical improvement. This case suggests a possible rare adverse reaction to the vaccine, similar to natural infection, and further research is needed to confirm a causal relationship.

EUROPEAN HEART JOURNAL-CASE REPORTS (2022)

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Letter Medicine, General & Internal

Myocarditis and Pericarditis After Vaccination for COVID-19

George A. Diaz et al.

Summary: This study compares the incidence of myocarditis and pericarditis in emergency department or inpatient hospital encounters before and during the period of COVID-19 vaccination availability in a large US health care system.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Medicine, General & Internal