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Article
Multidisciplinary Sciences
Ayland C. Letsinger et al.
Summary: Individuals infected with SARS-CoV-2 may develop neurological-related post-acute disorders, and nicotine may reduce the severity of infection according to disputed epidemiological data. However, exposing hACE2 mice to nicotine in drinking water did not change their mortality rate. Nonetheless, pre-exposure to nicotine decreased the expression of SARS-CoV-2 RNA and pathology in the brain, suggesting potential mechanisms for preventing the neurovirulence of the virus.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
M. R. Galanti et al.
Summary: Smoking is negatively associated with the risk of COVID-19, while the use of smokeless tobacco (snus) is associated with an increased risk. The hypothesis of a protective role of nicotine in the pathogenesis of the disease is not supported by the findings.
SCIENTIFIC REPORTS
(2023)
Article
Public, Environmental & Occupational Health
D. Ponticelli et al.
Summary: This research aimed to investigate the possible association between smoking habits and the incidence of adverse effects (AEs) after mRNA COVID-19 vaccine. A sample of Italian healthcare workers was longitudinally observed, and the occurrence of AEs after vaccination was evaluated. The study found a correlation between smoking habits and some adverse reactions after COVID-19 vaccination.
Review
Medicine, General & Internal
Vasiliki Tsampasian et al.
Summary: Post-COVID-19 condition (PCC) is a complex disorder that has affected millions of people globally. Identifying potential risk factors to understand who is at risk of developing PCC is important for early clinical support.
JAMA INTERNAL MEDICINE
(2023)
Article
Microbiology
Abenaya Muralidharan et al.
Summary: Lung conditions like COPD and risk factors like alcohol misuse and cigarette smoking can worsen the severity of COVID-19. Short exposure to alcohol or cigarette smoke can exacerbate the infection and associated injury in COPD patients, impairing lung defenses.
Article
Multidisciplinary Sciences
Linsey M. Porter et al.
Summary: The impact of cigarette smoke on ACE2 isoform expression and SARS-CoV-2 infection was investigated in this study. It was found that cigarette smoke did not significantly affect ACE2 expression or airway cell infection. Nicotine did not alter ACE2 expression, but NRF2 agonists did. These findings support the epidemiological data suggesting that smokers are not at increased risk of SARS-CoV-2 infection.
Letter
Allergy
Hananeh Aliee et al.
Article
Medicine, Research & Experimental
Valerian Dormoy et al.
Summary: Nicotinic acetylcholine receptors (nAChRs) are implicated in respiratory diseases, and researchers suggest they may be involved in the pathogenesis of SARS-CoV-2 respiratory syndrome. By analyzing molecular similarities, they propose that nAChR subunits could act as co-receptors for the SARS-CoV-2 Spike protein.
MEDICAL HYPOTHESES
(2022)
Article
Medicine, General & Internal
Venera Tomaselli et al.
Summary: The study found a lower proportion of positive SARS-CoV-2 serology among current smokers, using direct laboratory measures of tobacco exposure and thus avoiding possible bias associated with self-reported smoking status. Results may also serve as a reference for future clinical research on potential pharmaceutical role of nicotine or nicotinic-cholinergic agonists against COVID-19.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Uan- Chen et al.
Summary: This study examines the factors associated with COVID-19-related deaths using a large dataset. The findings indicate that age, sex, obesity, race, region, and various chronic diseases are associated with COVID-19-related deaths.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Article
Multidisciplinary Sciences
Fang Zheng et al.
Summary: This study conducted cytotoxicity assays in Vero E6 cells to examine the potential cytoprotective activity of nicotine against SARS-CoV-2 infection. The results demonstrated for the first time that nicotine had no significant cytoprotective activity against SARS-CoV-2 infection in these cells.
Review
Respiratory System
Constantine Vardavas et al.
Summary: By adjusting for age and gender data, we have identified population subgroups at an elevated risk for adverse outcomes from COVID-19, including those with specific underlying medical conditions. Prioritizing booster vaccinations and implementing protective measures for these populations may contribute to a reduction in adverse outcomes from COVID-19.
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Medicine, General & Internal
Yue He et al.
Summary: This study investigated the effect of smoking on the severity of COVID-19 and found that current smoking is a risk factor for severe disease. Active smoking may significantly increase the risk of COVID-19 progression towards severe disease.
Review
Cardiac & Cardiovascular Systems
Gaurav Agarwal et al.
Summary: VTE in COVID-19 is associated with male gender and severe disease, but not with traditional risk factors for VTE. Prophylactic and therapeutic anticoagulation does not appear to mitigate the occurrence of VTE.
THERAPEUTIC ADVANCES IN CARDIOVASCULAR DISEASE
(2022)
Review
Medicine, General & Internal
Peter Sarich et al.
Summary: This study conducted a systematic review and meta-analyses to assess smoking behavior changes during the early stages of the COVID-19 pandemic. The findings indicate that smoking prevalence decreased during the pandemic, but there were similar proportions of smokers who increased or decreased their smoking. Implementing evidence-based tobacco control policies and programs is crucial in preventing the exacerbation of smoking issues and associated adverse health outcomes during the COVID-19 pandemic.
Review
Substance Abuse
David Simons et al.
Summary: The study shows that current smokers have a lower risk of SARS-CoV-2 infection compared to never smokers, while former smokers have a higher risk of hospitalization, disease severity, and mortality from COVID-19.
Article
Nursing
Jeanne M. Sorrell
Summary: As COVID-19 claims the lives of many older adults worldwide, with 80% of deaths occurring in those aged 65 and above, reflections on the loss of this generation are crucial. Lockdowns and visitor restrictions meant to protect older adults have led to isolation and declining health, while ageist stereotypes continue to devalue them. There is much to be learned from this generation and their experiences.
JOURNAL OF PSYCHOSOCIAL NURSING AND MENTAL HEALTH SERVICES
(2021)
Article
Respiratory System
M. Tomchaney et al.
Summary: ACE2 levels in both bronchial and alveolar epithelial cells were decreased in COPD patients and CS-exposed mice. Pre-exposure to CS significantly inhibited SARS-CoV-2 replication in vitro, highlighting the need for further investigation into the effects of CS and COPD on SARS-CoV-2 infection.
BMC PULMONARY MEDICINE
(2021)
Letter
Medicine, General & Internal
Ernest Lo et al.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2020)
Letter
Medicine, General & Internal
Giuseppe Lippi et al.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2020)
Letter
Public, Environmental & Occupational Health
Fei Ran Guo
JOURNAL OF PUBLIC HEALTH
(2020)
Review
Environmental Sciences
IfeanyiChukwu O. Onor et al.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2017)
