期刊
EUROPEAN JOURNAL OF HAEMATOLOGY
卷 110, 期 6, 页码 680-687出版社
WILEY
DOI: 10.1111/ejh.13950
关键词
advanced extra-nodal NK/T-cell lymphoma (ENKTL); autologous hematopoietic stem cell transplantation (ASCT); chemotherapy
类别
This study aimed to investigate the effectiveness and safety of autologous hematopoietic stem cell transplantation (ASCT) in advanced extra-nodal NK/T-cell lymphoma (ENKTL) patients in first complete remission. The study found that patients who underwent ASCT had significantly better 2-year overall survival (OS) and 2-year progression-free survival (PFS) compared to those who only received chemotherapy. However, further prospective clinical trials are needed to confirm these findings.
Objectives: The advanced extra-nodal NK/T-cell lymphoma (ENKTL) is highly aggressive and lacks effective treatment with a poor prognosis. This study aimed to investigate the effectiveness and safety of autologous hematopoietic stem cell transplantation (ASCT) in CR1. Methods: Forty of 121 patients with advanced ENKTL from four Chinese hospitals between January 2006 to December 2021 who achieved first complete remission (CR1) and received at least 4 cycles chemotherapy, were enrolled for analysis. Twenty patients received ASCT as up-front consolidation therapy (Group A), and 20 patients only received chemotherapy (Group B). Clinical features, treatment and follow-up information were collected. Results: With a median follow-up of 27 months (range, 4-188 months), the 2-year overall survival (OS) in Group A, 61% (95% CI 37%-85%), was better than that in Group B, 26% (95% CI 2%-50%), p = .018. The 2-year progression-free survival (PFS) was 56% (95% CI 32%-80%) in Group A, 26% (95% CI 2%-50%) in Group B, p = .026. III-IV grade hematological toxicity was the most common adverse event. No treatment-related deaths were observed in both groups. Conclusion: Up-front ASCT could improve survival of advanced ENKTL patients in first complete remission, but need be confirmed by a prospective clinical trial.
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