Function follows form: How cell size is harnessed for developmental decisions

Cell size has profound effects on biological function, influencing a wide range of processes, including biosynthetic capacity, metabolism, and nutrient uptake. As a result, size is typically maintained within a narrow, population-specific range through size control mechanisms, which are an active area of study. While the physiological consequences of cell size are relatively well-characterized, less is known about its developmental consequences, and specifically its effects on developmental transitions. In this review, we compare systems where cell size is linked to developmental transitions, paying particular attention to examples from plants. We conclude by proposing that size can offer a simple readout of complex inputs, enabling flexible decisions during plant development.

Automated summary

Cell size has significant effects on biological function, such as biosynthetic capacity, metabolism, and nutrient uptake. Maintaining cell size within a specific range is crucial and is regulated by size control mechanisms. While the physiological consequences of cell size are well-known, its developmental consequences, especially its impact on developmental transitions, are less understood. This review compares systems where cell size is linked to developmental transitions, with a focus on examples from plants. The review concludes by suggesting that cell size can serve as a simple readout of complex inputs, allowing for flexible decisions during plant development.