4.7 Article

Efficacy and safety of maintenance olaparib and bevacizumab in ovarian cancer patients aged & GE;65 years from the PAOLA-1/ENGOT-ov25 trial

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Efficacy and safety of olaparib according to age in BRCA1/2-mutated patients with recurrent platinum-sensitive ovarian cancer: Analysis of the phase III SOLO2/ENGOT-Ov21 study

Fabian Trillsch et al.

Summary: The efficacy and safety of olaparib in older patients with recurrent platinum-sensitive ovarian cancer (PSOC) are comparable to younger patients, but older patients have higher discontinuation rates and more frequent occurrence of AML/MDS, with no clear effects on overall survival.

GYNECOLOGIC ONCOLOGY (2022)

Article Oncology

Efficacy of maintenance olaparib plus bevacizumab according to clinical risk in patients with newly diagnosed, advanced ovarian cancer in the phase III PAOLA-1/ENGOT-ov25 trial

Philipp Harter et al.

Summary: In the PAOLA-1 trial, maintenance olaparib plus bevacizumab provided a substantial PFS benefit in both higher-risk and lower-risk patients compared to bevacizumab alone. In the HRD-positive subgroup, olaparib plus bevacizumab showed significant PFS improvement in lower-risk patients.

GYNECOLOGIC ONCOLOGY (2022)

Review Oncology

Older adult participation in cancer clinical trials: A systematic review of barriers and interventions

Mina S. Sedrak et al.

Summary: Cancer is a disease of aging, and the number of older patients with cancer is increasing. However, older patients are underrepresented in cancer research and effective strategies to improve their participation in clinical trials are sparse. Studies on barriers and interventions for older adults in cancer trials are limited, highlighting a need for more evidence-based solutions to address this issue.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Molecular characterization of high-grade serous ovarian cancers occurring in younger and older women

Olga T. Filippova et al.

Summary: Younger HGSOC patients more frequently carry pathogenic BRCA1 germline mutations and genomic features of HRD, while older patients preferentially display aging-related mutational signatures, fewer pathogenic BRCA1 germline mutations and genomic features of HRD.

GYNECOLOGIC ONCOLOGY (2021)

Article Oncology

Efficacy and Safety of First-line Single-Agent Carboplatin vs Carboplatin Plus Paclitaxel for Vulnerable Older Adult Women With Ovarian Cancer A Randomized Clinical Trial

Claire Falandry et al.

Summary: This study conducted a randomized clinical trial for vulnerable older patients with ovarian cancer, and found that single-agent carboplatin was less effective with significantly worse survival outcomes compared to every-3-weeks or weekly carboplatin-paclitaxel regimens.

JAMA ONCOLOGY (2021)

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Review Oncology

BRCA1 Promoter Methylation and Clinical Outcomes in Ovarian Cancer: An Individual Patient Data Meta-Analysis

Roshni D. Kalachand et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2020)

Article Medicine, General & Internal

Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer

A. Gonzalez-Martin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer

I. Ray-Coquard et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Maintenance Olaparib in Patients with Newly Diagnosed Advanced Ovarian Cancer

K. Moore et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Oncology

Contribution of age to clinical trial enrollment and tolerance with ovarian cancer

Jessica Gillen et al.

GYNECOLOGIC ONCOLOGY (2017)

Article Oncology

Annual Report to the Nation on the Status of Cancer, 1975-2014, Featuring Survival

Ahmedin Jemal et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Article Oncology

Annual Report to the Nation on the Status of Cancer, 1975-2014, Featuring Survival

Ahmedin Jemal et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Article Medicine, General & Internal

Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer

M. R. Mirza et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Oncology

Prognostic Factors for Ovarian Epithelial Cancer in the Elderly A Case-Control Study

Renaud Sabatier et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2015)

Editorial Material Oncology

Under-Representation of Older Adults in Cancer Registration Trials: Known Problem, Little Progress

Kevin S. Scher et al.

JOURNAL OF CLINICAL ONCOLOGY (2012)