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Unmet needs in valvular heart disease

EUROPEAN HEART JOURNAL (2023)

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Article Cardiac & Cardiovascular Systems

Transfemoral aortic valve implantation: procedural hospital volume and mortality in Germany

Kurt Bestehorn et al.

Summary: Analyzing data from the German mandatory quality assurance registry, this study found a weak association between hospital volume and in-hospital mortality in patients undergoing transfemoral transcatheter aortic valve implantation (TF-TAVI) in Germany in 2018 and 2019. The study suggests that hospital volume may not be a reliable indicator of surgical quality.

EUROPEAN HEART JOURNAL (2023)

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Editorial Material Cardiac & Cardiovascular Systems

Contemporary Issues in Cardiology Practice Aortic Stenosis in the Low-Risk Patient: Overview of the Management Options and Possible Permutations

Kenza Rahmouni et al.

Summary: This article reviews the options for initial and subsequent interventions for managing aortic stenosis in low-risk patients, including surgical valve replacement, transcatheter aortic valve implantation (TAVI), and the Ross procedure. Choosing the appropriate treatment strategy is challenging for young, low-risk patients due to their longer life expectancy and higher risk of valve-related complications.

CANADIAN JOURNAL OF CARDIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis: The AVATAR Trial

Marko Banovic et al.

Summary: This international randomized controlled trial evaluated the safety and efficacy of early surgical treatment in asymptomatic patients with severe aortic stenosis. The results showed that early surgery reduced the primary composite end point of all-cause death, acute myocardial infarction, stroke, or unplanned hospitalization for heart failure compared with conservative treatment.

CIRCULATION (2022)

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Article Cardiac & Cardiovascular Systems

TRI-SCORE: a new risk score for in-hospital mortality prediction after isolated tricuspid vale surgery

Julien Dreyfus et al.

Summary: The study developed a dedicated risk score model (TRI-SCORE) for predicting the outcome of patients undergoing ITVS for severe TR. The scoring system includes 8 parameters to help predict in-hospital mortality rates and guide clinical decision-making for patients with severe TR.

EUROPEAN HEART JOURNAL (2022)

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Article Cardiac & Cardiovascular Systems

Trends in aortic valve replacement for aortic stenosis: a French nationwide study

Virginia Nguyen et al.

Summary: The number of aortic valve replacements has doubled in a decade and TAVR became the dominant form of AVR in 2018. The improvement in patient profiles seems to have anticipated the demonstrated benefit of TAVR in intermediate and low-risk patients. For patients 75 years or older, TAVR should be considered as the first option.

EUROPEAN HEART JOURNAL (2022)

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Article Cardiac & Cardiovascular Systems

European Society of Cardiology: cardiovascular disease statistics 2021

Adam Timmis et al.

Summary: This report updates and expands upon the 2019 report, providing cardiovascular disease statistics for the 57 ESC member countries. The report highlights the determinants of CVD and the disparities among different countries.

EUROPEAN HEART JOURNAL (2022)

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Article Cardiac & Cardiovascular Systems

Risk-Adjusted, 30-Day Home Time After Transcatheter Aortic Valve Replacement as a Hospital-Level Performance Metric

Amgad Mentias et al.

Summary: This study evaluated the use of risk-adjusted, 30-day home time as a patient-centric performance metric for hospitals performing transcatheter aortic valve replacement (TAVR). The results showed that risk-adjusted, 30-day home time was inversely correlated with readmission and mortality rates, and its use led to reclassification in hospital performance compared to other metrics. This suggests that risk-adjusted, 30-day home time can provide a complementary assessment of hospital performance in TAVR procedures.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2022)

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Article Medicine, General & Internal

A survey of general practitioners' knowledge and clinical practice in relation to valvular heart disease

John P. Birrane et al.

Summary: Irish general practitioners showed good understanding of contemporary VHD treatment options but lacked confidence and consistency in evaluating patients for VHD. Improved access to echocardiography may help address these deficiencies, but the reorganisation of services will be necessary in a resource-limited public health service.

IRISH JOURNAL OF MEDICAL SCIENCE (2022)

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Article Cardiac & Cardiovascular Systems

2021 ESC/EACTS Guidelines for the management of valvular heart disease Developed by the Task Force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)

Alec Vahanian et al.

EUROPEAN HEART JOURNAL (2022)

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Article Cardiac & Cardiovascular Systems

Characteristics, management, and outcomes of patients with multiple native valvular heart disease: a substudy of the EURObservational Research Programme Valvular Heart Disease II Survey

Christophe Tribouilloy et al.

Summary: Patients with multiple native valvular heart disease are more common in women, have more severe heart failure and comorbidities, higher left atrial volumes and pulmonary pressures, lower survival rates, and higher rates of heart failure occurrence.

EUROPEAN HEART JOURNAL (2022)

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Review Cardiac & Cardiovascular Systems

Which patients with aortic stenosis should be referred to surgery rather than transcatheter aortic valve implantation?

Stephan Windecker et al.

Summary: Transcatheter aortic valve implantation (TAVI) has become a standard treatment option for patients with severe symptomatic aortic valve stenosis (AS). The selection between TAVI and surgical aortic valve replacement (SAVR) should be made by a multidisciplinary heart team, considering clinical and anatomical factors as well as patient preferences and lifetime management.

EUROPEAN HEART JOURNAL (2022)

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Article Cardiac & Cardiovascular Systems

Sex-Related Factors in Valvular Heart Disease

Rebecca T. Hahn et al.

Summary: There are numerous sex-based differences in valvular heart disease, including pathophysiology, disease progression, compensation, comorbidities, severity assessment, hemodynamics, and procedural risks/benefits. Understanding sex-specific responses to valvular heart disease can improve disease recognition, treatment strategies, and outcomes.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Trends in Utilization of Aortic Valve Replacement for Severe Aortic Stenosis

Shawn X. Li et al.

Summary: Despite the rapid growth of aortic valve replacement (AVR) for aortic stenosis (AS), many symptomatic severe AS patients remain undertreated.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Ninety-Day Risk-Standardized Home Time as a Performance Metric for Cardiac Surgery Hospitals in the United States

Amgad Mentias et al.

Summary: This study assessed the association of hospital-level risk-standardized home time for cardiac surgeries with other performance metrics and found that 90-day risk-standardized home time is an effective metric for assessing hospital performance in cardiac surgery, demonstrating positive correlation with annual surgical volume and negative correlation with mortality rate and readmission rate.

CIRCULATION (2022)

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Article Cardiac & Cardiovascular Systems

Management and Outcome of Patients Admitted With Tricuspid Regurgitation in France

David Messika-Zeitoun et al.

Summary: A nationwide study in France revealed a lack of comprehensive reports on the management and outcomes of TR patients, with conservatively managed patients showing high mortality and readmission rates within a short time span. Despite the poor prognosis, only a small percentage of patients received necessary surgical interventions.

CANADIAN JOURNAL OF CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Aortic valve replacement in Germany in 2019

Luise Gaede et al.

Summary: In 2019, in Germany, the in-hospital mortality of patients undergoing TV-TAVI and iSAVR was similar, with both procedures showing lower mortality ratios compared to the previous year, indicating technical improvements in both therapies.

CLINICAL RESEARCH IN CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Excess Mortality and Undertreatment of Women With Severe Aortic Stenosis

Christophe Tribouilloy et al.

Summary: Women with severe AS are diagnosed at later ages and have more symptoms than men. Despite prevalent symptoms, AVR is less often performed in women and 5-year excess mortality is noted in women versus men, even after age matching.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Cardiac & Cardiovascular Systems

Contemporary Management of Severe Symptomatic Aortic Stenosis

Marc Eugene et al.

Summary: Despite a Class I recommendation for intervention, one in five patients with severe symptomatic AS chose not to intervene, a decision particularly associated with older age and combined comorbidities. Transcatheter intervention was extensively used in octogenarians.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Valvular Heart Disease in Relation to Race and Ethnicity JACC Focus Seminar 4/9

Julio A. Lamprea-Montealegre et al.

Summary: Valvular heart disease poses a significant global public health challenge, with untreated rheumatic heart disease causing grave consequences. The role of race, ethnicity, and healthcare disparities in VHD research has been overlooked, despite evidence of major health care inequalities.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Community prevalence, mechanisms and outcome of mitral or tricuspid regurgitation

Thomas J. Cahill et al.

Summary: The study found that moderate or greater mitral regurgitation and tricuspid regurgitation are common in the community, age-dependent, and often underdiagnosed. Cases identified through screening were less symptomatic, more likely to have primary mitral regurgitation, and had a lower incidence of aortic valve disease.

HEART (2021)

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Article Cardiac & Cardiovascular Systems

Outcomes 2 Years After Transcatheter Aortic Valve Replacement in Patients at Low Surgical Risk

Martin B. Leon et al.

Summary: In low surgical risk patients with symptomatic severe aortic stenosis, the PARTNER 3 trial showed superiority of transcatheter aortic valve replacement (TAVR) over surgery for the primary endpoint at 1 year. However, at 2 years, differences in death and stroke between TAVR and surgery were no longer significant, and TAVR patients had an increased risk of valve thrombosis.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Utility of a Deep-Learning Algorithm to Guide Novices to Acquire Echocardiograms for Limited Diagnostic Use

Akhil Narang et al.

Summary: This study tested the effectiveness of using a DL algorithm software to obtain diagnostic transthoracic echocardiographic studies for novice operators, showing that this method can help novices acquire diagnostic-quality echocardiographic images.

JAMA CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis A Double-Blind Randomized Controlled Trial

Tania A. Pawade et al.

Summary: In a study involving 150 patients with calcific aortic stenosis, neither denosumab nor alendronic acid showed any effect in reducing the progression of aortic valve calcification. Further research is needed to explore alternative pathways and mechanisms to identify potential disease-modifying therapies for this condition.

CIRCULATION (2021)

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Review Cardiac & Cardiovascular Systems

Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis

Mark C. Blaser et al.

Summary: Calcific aortic valve disease is expected to almost triple in prevalence over the next 3 decades and currently lacks effective pharmacotherapy to halt its progression. Invasive aortic valve replacement remains the only treatment option, highlighting a substantial gap in care due to limited understanding of disease mechanisms and complex valvular microenvironment. Multiomics approaches, single-cell resolution studies, and systems biology strategies hold promise in shedding new light on valvular disease pathogenesis and identifying potential drug targets.

CIRCULATION RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

Electrocardiogram screening for aortic valve stenosis using artificial intelligence

Michal Cohen-Shelly et al.

Summary: The study aimed to develop an artificial intelligence-enabled electrocardiogram (AI-ECG) to identify patients with moderate to severe aortic stenosis (AS). The AI-ECG showed promising results in detecting AS, especially in a community screening setting.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Mitral Valve Atlas for Artificial Intelligence Predictions of MitraClip Intervention Outcomes

Yaghoub Dabiri et al.

Summary: This study describes the use of artificial intelligence to aid in selecting optimal MitraClip scenarios and generated the necessary MV geometrical data. Results show that the location and number of MitraClips can impact residual mitral regurgitation, and leaflet stresses do not follow a simple pattern.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Deep Learning Algorithm for Automated Cardiac Murmur Detection via a Digital Stethoscope Platform

John S. Chorba et al.

Summary: This research utilizes a deep learning algorithm to detect murmurs and valvular heart disease on a commercial digital stethoscope platform, showing comparable performance to expert cardiologists. The algorithm's sensitivity and specificity vary in different contexts, indicating wide application potential.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Cardiac & Cardiovascular Systems

Impact of sex on the management and outcome of aortic stenosis patients

David Bienjonetti-Boudreau et al.

Summary: This study aimed to assess the impact of sex on the management and outcome of patients with aortic stenosis (AS). Despite similar baseline hemodynamic AS severity, women were less likely to be referred for aortic valve replacement (AVR) and had higher mortality rates, especially in cases of discordant markers of AS severity.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Eight-year outcomes for patients with aortic valve stenosis at low surgical risk randomized to transcatheter vs. surgical aortic valve replacement

Troels Hojsgaard Jorgensen et al.

Summary: In a study comparing clinical outcomes and valve durability after 8 years of follow-up in patients with symptomatic severe aortic valve stenosis at low surgical risk treated with either transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR), no significant differences were found in the risk for all-cause mortality, stroke, or myocardial infarction, as well as the risk of bioprosthetic valve failure between the two groups.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Dissemination of Transcatheter Aortic Valve Replacement in the United States

Javier A. Valle et al.

Summary: This study analyzed the dissemination of TAVR in the United States and its impact on outcomes. The number of TAVR sites increased significantly from 198 to 556 from 2011 to 2018, with higher density sites showing lower procedural risk but increased 30-day and 1-year mortality risks. These findings suggest unintended consequences on procedural quality due to the expansion of TAVR services in the United States.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Review Cardiac & Cardiovascular Systems

Global epidemiology of valvular heart disease

Sean Coffey et al.

Summary: Valvular heart disease (VHD) is a major cause of physical function loss, decreased quality of life, and shortened longevity. Rheumatic heart disease remains the most common manifestation of VHD globally, while calcific aortic stenosis and degenerative mitral valve disease are also significant. Despite improvements in mortality related to rheumatic heart disease, deaths from calcific aortic stenosis have increased over the past 20 years.

NATURE REVIEWS CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Association Between Patient Survival and Clinician Variability in Treatment Rates for Aortic Valve Stenosis

J. Matthew Brennan et al.

Summary: The study showed that overall rates of aortic valve replacement (AVR) for patients with symptomatic severe aortic stenosis (ssAS) were low in the United States, with significant variation in treatment rates among managing cardiologists. Patients treated by cardiologists with lower AVR rates experienced significantly higher 1-year mortality than those treated by cardiologists with higher AVR rates.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Cardiac & Cardiovascular Systems

'Valve for Life': tackling the deficit in transcatheter treatment of heart valve disease in the UK

Noman Ali et al.

Summary: TAVI implementation in the UK is significantly lower compared to other European nations, with substantial geographic inequity in access within the country. Due to underprovision, long waiting times and significant mortality rates among those waiting intervention are prevailing issues.

OPEN HEART (2021)

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Article Cardiac & Cardiovascular Systems

Electrocardiogram screening for aortic valve stenosis using artificial intelligence

Michal Cohen-Shelly et al.

Summary: The study showed that AI-ECG has a certain degree of accuracy and reliability in identifying patients with moderate to severe AS, especially showing differences among patients of different ages and genders. For patients with false-positive AI-ECGs, the risk of developing moderate or severe AS within the next 15 years is twice that of true negative AI-ECGs.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Eight-year outcomes for patients with aortic valve stenosis at low surgical risk randomized to transcatheter vs. surgical aortic valve replacement

Troels Hojsgaard Jorgensen et al.

Summary: In patients with severe aortic valve stenosis at low surgical risk randomized to TAVI or SAVR, there were no significant differences in the risk for all-cause mortality, stroke, or myocardial infarction, as well as the risk of bioprosthetic valve failure after 8 years of follow-up. However, patients who underwent TAVI had a lower risk of structural valve deterioration compared to those who underwent SAVR.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Sex-Related Differences in the Extent of Myocardial Fibrosis in Patients With Aortic Valve Stenosis

Lionel Tastet et al.

JACC-CARDIOVASCULAR IMAGING (2020)

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Article Cardiac & Cardiovascular Systems

Presentation and management of calcific mitral valve disease

Isabel Shamsudeen et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2020)

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Article Medicine, General & Internal

Five-Year Outcomes of Transcatheter or Surgical Aortic-Valve Replacement

Raj R. Makkar et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Cardiac & Cardiovascular Systems

Functional tricuspid regurgitation of degenerative mitral valve disease: a crucial determinant of survival

Benjamin Essayagh et al.

EUROPEAN HEART JOURNAL (2020)

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Article Cardiac & Cardiovascular Systems

Impact of tricuspid regurgitation on survival in patients with heart failure: a large electronic health record patient-level database analysis

David Messika-Zeitoun et al.

EUROPEAN JOURNAL OF HEART FAILURE (2020)

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Article Cardiac & Cardiovascular Systems

Priorities for Patient-Centered Research in Valvular Heart Disease: A Report From the National Heart, Lung, and Blood Institute Working Group

Brian R. Lindman et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Article Cardiac & Cardiovascular Systems

Dismal Outcomes and High Societal Burden of Mitral Valve Regurgitation in France in the Recent Era: A Nationwide Perspective

David Messika-Zeitoun et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Article Cardiac & Cardiovascular Systems

The Natural History of Severe Calcific Mitral Stenosis

Nahoko Kato et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Isolated tricuspid valve surgery: impact of aetiology and clinical presentation on outcomes

Julien Dreyfus et al.

EUROPEAN HEART JOURNAL (2020)

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Review Cardiac & Cardiovascular Systems

Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019 Update From the GBD 2019 Study

Gregory A. Roth et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

STS-ACC TVT Registry of Transcatheter Aortic Valve Replacement

John D. Carroll et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Presentation and outcomes of mitral valve surgery in France in the recent era: a nationwide perspective

David Messika-Zeitoun et al.

OPEN HEART (2020)

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Article Cardiac & Cardiovascular Systems

Isolated tricuspid valve surgery: impact of aetiology and clinical presentation on outcomes

Julien Dreyfus et al.

EUROPEAN HEART JOURNAL (2020)

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Article Cardiac & Cardiovascular Systems

Causes and mechanisms of isolated mitral regurgitation in the community: clinical context and outcome

Volha Dziadzko et al.

EUROPEAN HEART JOURNAL (2019)

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Article Cardiac & Cardiovascular Systems

Racial Disparities in the Utilization and Outcomes of TAVR TVT Registry Report

Mohamad Alkhouli et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2019)

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Article Cardiac & Cardiovascular Systems

2019 AATS/ACC/ASE/SCAI/STS Expert Consensus Systems of Care Document: A Proposal to Optimize Care for Patients With Valvular Heart Disease

Rick A. Nishimura et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

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Review Cardiac & Cardiovascular Systems

Atrial Functional Mitral Regurgitation JACC Review Topic of the Week

Sebastien Deferm et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

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Article Medicine, General & Internal

Procedural Volume and Outcomes for Transcatheter Aortic-Valve Replacement

Sreekanth Vemulapalli et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Cardiac & Cardiovascular Systems

Excess Mortality Associated With Functional Tricuspid Regurgitation Complicating Heart Failure With Reduced Ejection Fraction

Giovanni Benfari et al.

CIRCULATION (2019)

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Letter Cardiac & Cardiovascular Systems

Echocardiographic Surveillance of Valvular Heart Disease in Different Sociodemographic Groups

Varsha K. Tanguturi et al.

JACC-CARDIOVASCULAR IMAGING (2019)

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Article Cardiac & Cardiovascular Systems

Burden of Tricuspid Regurgitation in Patients Diagnosed in the Community Setting

Yan Topilsky et al.

JACC-CARDIOVASCULAR IMAGING (2019)

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Editorial Material Cardiac & Cardiovascular Systems

Focused Cardiac Ultrasonography

Kirk T. Spencer et al.

JACC-CARDIOVASCULAR IMAGING (2019)

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Review Cardiac & Cardiovascular Systems

Multimodality Imaging Markers of Adverse Myocardial Remodeling in Aortic Stenosis

Thomas A. Treibel et al.

JACC-CARDIOVASCULAR IMAGING (2019)

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Article Cardiac & Cardiovascular Systems

Inequity in Access to Transcatheter Aortic Valve Replacement: a Pan-Canadian Evaluation of Wait-Times

Harindra C. Wijeysundera et al.

CANADIAN JOURNAL OF CARDIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Contemporary Presentation and Management of Valvular Heart Disease The EURObservational Research Programme Valvular Heart Disease II Survey

Bernard Iung et al.

CIRCULATION (2019)

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Article Cardiac & Cardiovascular Systems

Aortic Valve Stenosis Treatment Disparities in the Underserved JACC Council Perspectives

Wayne Batchelor et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Angiotensin Receptor Neprilysin Inhibitor for Functional Mitral Regurgitation PRIME Study

Duk-Hyun Kang et al.

CIRCULATION (2019)

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Article Cardiac & Cardiovascular Systems

Timing of Referral of Patients With Severe Isolated Tricuspid Valve Regurgitation to Surgeons (from a French Nationwide Database)

Julien Dreyfus et al.

AMERICAN JOURNAL OF CARDIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

Temporal Trends and Clinical Consequences of Wait Times for Transcatheter Aortic Valve Replacement: A Population-Based Study

Gabby Elbaz-Greener et al.

CIRCULATION (2018)

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Article Cardiac & Cardiovascular Systems

Educational needs and application of guidelines in the management of patients with mitral regurgitation. A European mixed-methods study

Bernard Iung et al.

EUROPEAN HEART JOURNAL (2018)

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Article Cardiac & Cardiovascular Systems

Clinical presentation and outcome of tricuspid regurgitation in patients with systolic dysfunction

Yan Topilsky et al.

EUROPEAN HEART JOURNAL (2018)

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Article Cardiac & Cardiovascular Systems

Cardiac auscultation poorly predicts the presence of valvular heart disease in asymptomatic primary care patients

Syed K. M. Gardezi et al.

HEART (2018)

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Article Cardiac & Cardiovascular Systems

Implementation of Transcatheter Aortic Valve Replacement in France

Virginia Nguyen et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

1-Year Outcomes of Transcatheter Mitral Valve Replacement in Patients With Severe Mitral Annular Calcification

Mayra Guerrero et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

Early results of robotically assisted mitral valve surgery: Analysis of the first 1000 cases

A. Marc Gillinov et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2018)

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Article Medicine, General & Internal

Outcome and undertreatment of mitral regurgitation: a community cohort study

Volha Dziadzko et al.

LANCET (2018)

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Article Medicine, General & Internal

Effect of Race on the Incidence of Aortic Stenosis and Outcomes of Aortic Valve Replacement in the United States

Fahad Alqahtani et al.

MAYO CLINIC PROCEEDINGS (2018)

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Article Cardiac & Cardiovascular Systems

Focused Cardiac Ultrasound by Nurses in Rural Vietnam

James N. Kirkpatrick et al.

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY (2018)

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Article Medicine, General & Internal

Transcatheter Mitral-Valve Repair in Patients with Heart Failure

G. W. Stone et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Medicine, General & Internal

Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation

J. -F. Obadia et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Letter Cardiac & Cardiovascular Systems

Asymptomatic Severe Aortic Stenosis With Preserved Ejection Fraction Early Surgery Versus Conservative Management

Yohann Bohbot et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

Outcomes of Patients With Asymptomatic Aortic Stenosis Followed Up in Heart Valve Clinics

Patrizio Lancellotti et al.

JAMA CARDIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

Standards defining a 'Heart Valve Centre': ESC Working Group on Valvular Heart Disease and European Association for Cardiothoracic Surgery Viewpoint

John B. Chambers et al.

EUROPEAN HEART JOURNAL (2017)

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Article Cardiac & Cardiovascular Systems

Epidemiology of valvular heart disease in a Swedish nationwide hospital-based register study

Pontus Andell et al.

HEART (2017)

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Article Cardiac & Cardiovascular Systems

National Trends and Outcomes in Isolated Tricuspid Valve Surgery

Chad J. Zack et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Relation of Mitral Valve Surgery Volume to Repair Rate, Durability, and Survival

Joanna Chikwe et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Article Medicine, General & Internal

Cohort profile: prevalence of valvular heart disease in community patients with suspected heart failure in UK

Anna Marciniak et al.

BMJ OPEN (2017)

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Article Cardiac & Cardiovascular Systems

Role of Hospital Volumes in Identifying Low-Performing and High-Performing Aortic and Mitral Valve Surgical Centers in the United States

Rohan Khera et al.

JAMA CARDIOLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Handheld Echocardiography: Current State and Future Perspectives

Mohammed A. Chamsi-Pasha et al.

CIRCULATION (2017)

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Article Cardiac & Cardiovascular Systems

Trends in aortic valve replacement in Germany in 2015: transcatheter versus isolated surgical aortic valve repair

Luise Gaede et al.

CLINICAL RESEARCH IN CARDIOLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Sex-related differences in calcific aortic stenosis: correlating clinical and echocardiographic characteristics and computed tomography aortic valve calcium score to excised aortic valve weight

Jeremy J. Thaden et al.

EUROPEAN HEART JOURNAL (2016)

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Article Cardiac & Cardiovascular Systems

Handheld echocardiographic screening for rheumatic heart disease by non-experts

Michelle Ploutz et al.

HEART (2016)

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Article Cardiac & Cardiovascular Systems

Large-scale community echocardiographic screening reveals a major burden of undiagnosed valvular heart disease in older people: the OxVALVE Population Cohort Study

Joanna L. d'Arcy et al.

EUROPEAN HEART JOURNAL (2016)

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Article Cardiac & Cardiovascular Systems

Hand-held cardiac ultrasound screening performed by family doctors with remote expert support interpretation

Arturo Evangelista et al.

HEART (2016)

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Article Cardiac & Cardiovascular Systems

Aortic valve stenosis: what do people know? A heart valve disease awareness survey of over 8,800 people aged 60 or over

Luise Gaede et al.

EUROINTERVENTION (2016)

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Review Cardiac & Cardiovascular Systems

Comparison of clinical outcomes between bioresorbable vascular stents versus conventional drug-eluting and metallic stents: a systematic review and meta-analysis

Maciej Banach et al.

EUROINTERVENTION (2016)

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Article Cardiac & Cardiovascular Systems

Robotic Mitral Valve Repair for Simple and Complex Degenerative Disease Midterm Clinical and Echocardiographic Quality Outcomes

Rakesh M. Suri et al.

CIRCULATION (2015)

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Article Cardiac & Cardiovascular Systems

Hospital volume, mitral repair rates, and mortality in mitral valve surgery in the elderly: An analysis of US hospitals treating Medicare fee-for-service patients

Christina M. Vassileva et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2015)

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Article Cardiac & Cardiovascular Systems

Is there an outcome penalty linked to guideline-based indications for valvular surgery? Early and long-term analysis of patients with organic mitral regurgitation

Maurice Enriquez-Sarano et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2015)

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Article Genetics & Heredity

Genetic association analyses highlight biological pathways underlying mitral valve prolapse

Christian Dina et al.

NATURE GENETICS (2015)

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Editorial Material Medicine, General & Internal

How should specialist competencies in heart valve disease be recognized?

J. Chambers et al.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2015)

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Article Cardiac & Cardiovascular Systems

Racial Differences in the Prevalence of Severe Aortic Stenosis

Devin K. Patel et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2014)

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Article Cardiac & Cardiovascular Systems

Gender Differences in Long-Term Survival of Medicare Beneficiaries Undergoing Mitral Valve Operations

Christina M. Vassileva et al.

ANNALS OF THORACIC SURGERY (2013)

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Article Cardiac & Cardiovascular Systems

Long-Term Survival of Patients Undergoing Mitral Valve Repair and Replacement A Longitudinal Analysis of Medicare Fee-for-Service Beneficiaries

Christina M. Vassileva et al.

CIRCULATION (2013)

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Article Cardiac & Cardiovascular Systems

Sex Differences in Aortic Valve Calcification Measured by Multidetector Computed Tomography in Aortic Stenosis

Shivani R. Aggarwal et al.

CIRCULATION-CARDIOVASCULAR IMAGING (2013)

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Article Medicine, General & Internal

Association Between Early Surgical Intervention vs Watchful Waiting and Outcomes for Mitral Regurgitation Due to Flail Mitral Valve Leaflets

Rakesh M. Suri et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

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Article Medicine, General & Internal

Genetic Associations with Valvular Calcification and Aortic Stenosis

George Thanassoulis et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Cardiac & Cardiovascular Systems

Pocket-size hand-held cardiac ultrasound as an adjunct to clinical examination in the hands of medical students and junior doctors

Vasileios F. Panoulas et al.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING (2013)

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Article Medicine, General & Internal

Echocardiographic Screening of the General Population and Long-term Survival A Randomized Clinical Study

Haakon Lindekleiv et al.

JAMA INTERNAL MEDICINE (2013)

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Article Cardiac & Cardiovascular Systems

A near 100% repair rate for mitral valve prolapse is achievable in a reference center: Implications for future guidelines

Javier G. Castillo et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2012)

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Article Cardiac & Cardiovascular Systems

A propensity score-adjusted retrospective comparison of early and mid-term results of mitral valve repair versus replacement in octogenarians

Joanna Chikwe et al.

EUROPEAN HEART JOURNAL (2011)

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Article Cardiac & Cardiovascular Systems

Early Surgery Versus Conventional Treatment in Asymptomatic Very Severe Aortic Stenosis

Duk-Hyun Kang et al.

CIRCULATION (2010)

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Article Cardiac & Cardiovascular Systems

Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis Results of the Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) Trial

Kwan Leung Chan et al.

CIRCULATION (2010)

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Article Medicine, General & Internal

Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis

Anne B. Rossebo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Article Medicine, General & Internal

Burden of valvular heart diseases: a population-based study

Vuyisile T. Nkomo et al.

LANCET (2006)

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Article Cardiac & Cardiovascular Systems

Surgical correction of mitral regurgitation in the elderly - Outcomes and recent improvements

Delphine Detaint et al.

CIRCULATION (2006)

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Article Medicine, General & Internal

A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis

SJ Cowell et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

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Article Cardiac & Cardiovascular Systems

Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation

WC Roberts et al.

CIRCULATION (2005)

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