RBM15 m6A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling

Article Cell Biology

OTUB2 promotes the progression of endometrial cancer by regulating the PKM2-mediated PI3K/AKT signaling pathway

Qian Zhang et al.

Summary: OTUB2 is upregulated in endometrial carcinoma (EC), and its overexpression promotes glycolysis and induces the proliferation, migration, and invasion of EC cells through regulating the PKM2/PI3K/AKT signaling pathway.

CELL BIOLOGY INTERNATIONAL (2023)

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Article Environmental Sciences

Induction of immunogenic cell death effect of licoricidin in cervical cancer cells by enhancing endoplasmic reticulum stress-mediated high mobility group box 1 expression

Pei-Ju Wu et al.

Summary: Licoricidin, an active compound of Glycyrrhiza uralensis, was found to significantly inhibit cell viability and induce apoptosis in cervical cancer cells. It also triggered endoplasmic reticulum stress and upregulated the protein expression of GRP78 (Bip), CHOP, and IRE1 alpha, ultimately leading to immunogenic cell death. These findings suggest that Licoricidin may be a potential inducer of immunotherapy in advanced cervical cancer.

ENVIRONMENTAL TOXICOLOGY (2023)

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Article Environmental Sciences

EF-24 inhibits TPA-induced cellular migration and MMP-9 expression through the p38 signaling pathway in cervical cancer cells

Chung-Yuan Lee et al.

Summary: The synthetic curcumin analog, EF-24, has been shown to have enhanced bioavailability and stronger anti-inflammatory and anti-cancer activity compared to curcumin. This study investigated the effects of EF-24 on TPA-induced cellular migration of cervical cancer and found that EF-24 significantly reduced cellular migration and invasion. Further analysis revealed that EF-24 modulated MMP-9 expression by inhibiting the phosphorylation of the p38 signaling pathway. These findings suggest that EF-24 may have potential as a chemopreventive agent for cervical cancer.

ENVIRONMENTAL TOXICOLOGY (2023)

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Article Biochemistry & Molecular Biology

Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis

Shuyu Yu et al.

Summary: Aberrant regulation of ubiquitination can lead to metabolic reprogramming in tumor cells. OTUB2, an OTU deubiquitinase, is upregulated in colorectal cancer and exacerbates its progression by modulating aerobic glycolysis. Depletion of OTUB2 reduces glucose consumption, lactate production, and cellular ATP production, as well as sensitizing CRC cells to chemotherapy drugs.

ONCOGENE (2022)

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Article Biotechnology & Applied Microbiology

LINC00665 sponges miR-641 to promote the progression of breast cancer by targeting the SNF2-related CREBBP activator protein (SRCAP)

Wen Cao et al.

Summary: This research reveals that LINC00665 plays a crucial role as a competing endogenous RNA (ceRNA) in breast cancer. It promotes the survival and metastasis of breast cancer cells by regulating miR-641 and SRCAP.

BIOENGINEERED (2022)

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Article Cell Biology

OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer

Siwen Ouyang et al.

Summary: OTUB2 is overexpressed in gastric cancer and acts as an oncogene, which is associated with poor prognosis in patients. OTUB2 regulates KRT80 stability via deubiquitination, promoting gastric cancer proliferation, and could potentially serve as a novel prognostic marker.

CELL DEATH DISCOVERY (2022)

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Article Environmental Sciences

Antitumor activity of pachymic acid in cervical cancer through inducing endoplasmic reticulum stress, mitochondrial dysfunction, and activating the AMPK pathway

Ting Yang et al.

Summary: Pachymic acid exhibits anti-tumor activity in cervical cancer by inducing ER stress, mitochondrial dysfunction, and activating the AMPK pathway.

ENVIRONMENTAL TOXICOLOGY (2022)

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Article Biochemistry & Molecular Biology

Epigenetic activation of RBM15 promotes clear cell renal cell carcinoma growth, metastasis and macrophage infiltration by regulating the m6A modification of CXCL11

Xing Zeng et al.

Summary: This study found that RBM15 is upregulated in clear cell renal cell carcinoma (ccRCC) and enhances the proliferation, migration, and invasion of tumor cells. RBM15 promotes macrophage infiltration and M2 polarization by promoting the secretion of CXCL11. This study provides new insights into ccRCC therapy.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

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Article Biochemistry & Molecular Biology

ERK/RSK-mediated phosphorylation of Y-box binding protein-1 aggravates diabetic cardiomyopathy by suppressing its interaction with deubiquitinase OTUB1

Xiaodan Zhong et al.

Summary: The study found that phosphorylation of YB-1 protein at the S102 site is elevated in diabetic cardiomyopathy, leading to degradation of YB-1 due to disrupted interaction with otubain-1 deubiquitinase under hyperglycemic conditions. Inhibition of the ERK pathway was shown to ameliorate features of DCM by stabilizing YB-1 protein expression through preventing its phosphorylation at S102.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

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Article Clinical Neurology

Morphine in Combination with Ketamine Improves Cervical Cancer Pain and Suppresses Immune Function via the JAK3/STAT5 Pathway

Yurong Jiang et al.

Summary: This study aimed to explore the role of morphine and ketamine on cancer pain and T cells of patients with cervical cancer (CC). The results showed that the combination of morphine and ketamine relieved cancer pain more effectively than morphine alone and decreased immune function through the JAK3/STAT5 pathway.

PAIN RESEARCH & MANAGEMENT (2022)

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Review Oncology

The epigenetic correlation among ovarian cancer, endometriosis and PCOS: A review

P. K. Harinee Throwba et al.

Summary: There is a potential correlation between ovarian cancer, endometriosis, and PCOS, which may trigger cancer progression and metastasis through genetic and epigenetic factors.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2022)

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Review Biochemistry & Molecular Biology

Pleiotropic effects of DCLK1 in cancer and cancer stem cells

Dibyashree Chhetri et al.

Summary: DCLK1, a tumor stem cell marker in various cancers, is closely associated with tumor cell proliferation and metastasis. Targeting the DCLK1 gene and regulating the pathways controlled by DCLK1 may provide potential strategies to inhibit tumor growth and metastasis in gastrointestinal cancer.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Article Biochemistry & Molecular Biology

Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer's disease and tauopathy models

Karthikeyan Selvarasu et al.

Summary: This study found that KIF5B is involved in tau homeostasis in AD cells and animal models. By decreasing KIF5B levels, abnormal tau behavior can be reduced, thereby preventing and slowing down AD and other tauopathies.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Article Oncology

CDKN2A inhibits cell proliferation and invasion in cervical cancer through LDHA-mediated AKT/mTOR pathway

Y. Luan et al.

Summary: The study showed that CDKN2A inhibits cell proliferation and invasion in cervical cancer through the LDHA-mediated AKT-mTOR pathway.

CLINICAL & TRANSLATIONAL ONCOLOGY (2021)

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Article Cell Biology

Tumor purity as a prognosis and immunotherapy relevant feature in cervical cancer

Yali Deng et al.

Aging-US (2021)

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Article Oncology

RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent

Xin Wang et al.

Summary: The study found a significant increase in global mRNA m6A methylation levels in patients with laryngeal squamous cell carcinoma (LSCC), highlighting the essential roles of RBM15 and IGF2BP3 in m6A methylation modification. This study identified a novel RNA regulatory mechanism in LSCC.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Environmental Sciences

G2 and S phase-expressed-1 acts as a putative tumor promoter in cervical cancer by enhancing Wnt/β-catenin signaling via modulation of GSK-3β

Wenting Guo et al.

Summary: This study shows that GTSE1 is overexpressed in cervical cancer and its suppression inhibits tumor growth by down-regulating Wnt/β-catenin signaling pathway. GTSE1 knockdown reduces cell proliferation and invasion abilities in cervical cancer cells, and impedes in vivo tumorigenicity.

ENVIRONMENTAL TOXICOLOGY (2021)

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Review Immunology

N6 -Methyladenosine and Rheumatoid Arthritis: A Comprehensive Review

Sha Wu et al.

Summary: Rheumatoid arthritis is characterized by immune cell infiltration and destruction of cartilage and bone. Studies have shown that m(6)A modification is related to the pathogenesis of RA, providing evidence for the development of new therapies. The relationship between m(6)A enzymes, immune cells, and RA is important for understanding and treating this autoimmune disease.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

RBM15 promotes hepatocellular carcinoma progression by regulating N6-methyladenosine modification of YES1 mRNA in an IGF2BP1-dependent manner

Xianlei Cai et al.

Summary: RBM15 is highly expressed in HCC, associated with poor prognosis, and may facilitate HCC progression through m(6)A modification, with the IGF2BP1-YES1-MAPK axis playing a crucial role.

CELL DEATH DISCOVERY (2021)

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Article Environmental Sciences

TRIP13 exerts a cancer-promoting role in cervical cancer by enhancing Wnt/β-catenin signaling via ACTN4

Xiaoying Liu et al.

Summary: The study reveals that TRIP13 is significantly increased in cervical cancer tissue, with high expression predicting a lower survival rate. TRIP13 accelerates proliferation and invasion of cervical cancer cells by enhancing Wnt/beta-catenin signaling and modulating ACTN4. These findings suggest a potential role for TRIP13 as a target for cervical cancer treatment.

ENVIRONMENTAL TOXICOLOGY (2021)

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Article Environmental Sciences

Inhibition of the notch signaling pathway overcomes resistance of cervical cancer cells to paclitaxel through retardation of the epithelial-mesenchymal transition process

Tianzhu Sun et al.

Summary: Studies have shown that cervical cancer cells develop an EMT phenotype partly through activation of the Notch1 signaling pathway, leading to resistance to paclitaxel. Targeting the Notch1 signaling pathway may be a strategy to reverse the EMT phenotype and increase sensitivity of cervical cancer cells to paclitaxel treatment.

ENVIRONMENTAL TOXICOLOGY (2021)

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Article Environmental Sciences

Brucine promotes apoptosis in cervical cancer cells (ME-180) via suppression of inflammation and cell proliferation by regulating PI3K/AKT/mTOR signaling pathway

Vidya Devanathadesikan Seshadri

Summary: Brucine, as a main constituent of Strychnos nux-vomica, has been shown to possess anti-inflammatory, analgesic and anti-tumor properties, with recent research focusing on its potential anti-cervical cancer activity. Results indicate that brucine inhibits inflammation, cell proliferation and promotes apoptosis by down-regulating multiple signaling pathways.

ENVIRONMENTAL TOXICOLOGY (2021)

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Article Oncology

CD155 Promotes the Progression of Cervical Cancer Cells Through AKT/mTOR and NF-κB Pathways

Lu Liu et al.

Summary: The study found that the expression of CD155 gradually increases in cervical cancer, reducing CD155 expression can inhibit cell proliferation and tumor formation, while CD155 overexpression has the opposite effect. Interaction between CD155 and AKT forms a complex, activating the AKT/mTOR/NF-κB pathway and inhibiting autophagy and apoptosis.

FRONTIERS IN ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

LncRNA GHET1 promotes cervical cancer progression through regulating AKT/mTOR and Wnt/β-catenin signaling pathways

Zhihui Liu et al.

BIOSCIENCE REPORTS (2020)

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Article Medicine, Research & Experimental

Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-κB signaling

Zhen-Lin Gu et al.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2020)

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Article Cell Biology

Lipid desaturation-associated endoplasmic reticulum stress regulates MYCN gene expression in hepatocellular carcinoma cells

Xian-Yang Qin et al.

CELL DEATH & DISEASE (2020)

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Article Environmental Sciences

Dioscorea nipponica Makino suppresses TPA-induced migration and invasion through inhibition of matrix metalloproteinase-9 in human cervical cancer cells

Chung-Yuan Lee et al.

ENVIRONMENTAL TOXICOLOGY (2020)

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Review Biochemistry & Molecular Biology

Mechanism of RNA modification N6-methyladenosine in human cancer

Zijian Zhou et al.

MOLECULAR CANCER (2020)

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Article Oncology

Immune Activation in Patients with Locally Advanced Cervical Cancer Treated with Ipilimumab Following Definitive Chemoradiation (GOG-9929)

Diane M. Da Silva et al.

CLINICAL CANCER RESEARCH (2020)

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Article Multidisciplinary Sciences

Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

Junmei Yi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Oncology

Analysis of N6-Methyladenosine Methyltransferase Reveals METTL14 and ZC3H13 as Tumor Suppressor Genes in Breast Cancer

Peng-Ju Gong et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Cell & Tissue Engineering

OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer

Qiuyuan Wan et al.

CELL TRANSPLANTATION (2020)

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Article Environmental Sciences

Antimetastatic effects of Terminalia catappa leaf extracts on cervical cancer through the inhibition of matrix metalloprotein-9 and MAPK pathway

Chung-Yuan Lee et al.

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Review Biochemistry & Molecular Biology

Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson's Disease

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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The role of m6A RNA methylation in cancer

Ting Sun et al.

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WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1

Yunhao Chen et al.

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Promoter methylation of SEPT9 as a potential biomarker for early detection of cervical cancer and its overexpression predicts radioresistance

Xinlin Jiao et al.

CLINICAL EPIGENETICS (2019)

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OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ

Zhengkui Zhang et al.

MOLECULAR CELL (2019)

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Letter Biology

Derlin1 functions as an oncogene in cervical cancer via AKT/mTOR signaling pathway

Ling Li et al.

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OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer

Jing Li et al.

THERANOSTICS (2019)

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Link Between m6A Modification and Cancers

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Environmentally relevant concentration of arsenic trioxide and humic acid promoted tumor progression of human cervical cancer cells: In vivo and in vitro studies

Min-Ling Tsai et al.

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ADA3 regulates normal and tumor mammary epithelial cell proliferation through c-MYC

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Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway

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Latex of Euphorbia antiquorum-induced S-phase arrest via active ATM kinase and MAPK pathways in human cervical cancer HeLa cells

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Gene expression regulation mediated through reversible m6A RNA methylation

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Crystal structure of human otubain 2

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RBM15 m6A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling

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