期刊
ENVIRONMENTAL TOXICOLOGY
卷 38, 期 9, 页码 2192-2203出版社
WILEY
DOI: 10.1002/tox.23856
关键词
AC012360; 1; hepatocellular carcinoma; lncRNA; LPCAT1; miR-139-5p
This study identified that lncRNA AC012360.1 is upregulated in hepatocellular carcinoma (HCC) tissues and promotes HCC progression by sponging miR-139-5p and upregulating LPCAT1 expression.
Long noncoding RNAs (lncRNAs) participate in tumorigenesis and tumor progression. However, whether lncRNA AC012360.1 contributes to hepatocellular carcinoma (HCC) is unknown. In HCC tissues, differentially expressed lncRNAs were identified by bioinformatics. AC012360.1 level was validated and its role in HCC progression was investigated. Among the top 10 upregulated lncRNAs, AC012360.1 exhibited the greatest increase in HCC tissues. Additionally, AC012360.1 was upregulated in HCC tissues/cells. Moreover, AC012360.1 knockdown refrained cell proliferation/metastasis and tumor growth. Conversely, AC012360.1 overexpression showed an oncogenic role. AC012360.1 and lysophosphatidylcholine acyltransferase 1 (LPCAT1) contained miR-139-5p binding sites. Furthermore, miR-139-5p silencing partially mitigated the role of AC012360.1 knockdown, while LPCAT1 knockdown partially abolished the tumor-promoting effect of AC012360.1 overexpression. In conclusion, AC012360.1 exhibited its oncogenic function in HCC through sponging miR-139-5p and upregulating LPCAT1 expression.
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