A novel mechanism of cannabidiol in suppressing ovarian cancer through LAIR-1 mediated mitochondrial dysfunction and apoptosis

Article Environmental Sciences

Ursolic acid reduces Adriamycin resistance of human ovarian cancer cells through promoting theHuRtranslocation from cytoplasm to nucleus

Wei Li et al.

Summary: The study demonstrates that ursolic acid can alleviate Adriamycin resistance in human ovarian cancer cells by modulating the HuR/MDR1 axis.

ENVIRONMENTAL TOXICOLOGY (2021)

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Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Environmental Sciences

Dual down-regulation of EGFR and ErbB2 by berberine contributes to suppression of migration and invasion of human ovarian cancer cells

Tzu-Chao Chuang et al.

Summary: Berberine reduces the motility and invasiveness of ovarian cancer cells by depleting EGFR and ErbB2, and down-regulating their downstream targets through the EGFR-ErbB2/PI3K/Akt signaling pathway.

ENVIRONMENTAL TOXICOLOGY (2021)

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Article Cell Biology

Eldecalcitol induces apoptosis and autophagy in human osteosarcoma MG-63 cells by accumulating ROS to suppress the PI3K/Akt/mTOR signaling pathway

Chaotao Zhang et al.

Summary: ED-71 induced G2/M arrest, apoptosis, and autophagy in human osteosarcoma cells by accumulating ROS to suppress the PI3K/Akt/mTOR signaling pathway.

CELLULAR SIGNALLING (2021)

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Article Biochemistry & Molecular Biology

Dioscorea deltoidea Leaf Extract (DDLE) Targets PI3K/AKT/mTOR Pathway and Inhibits Ovarian Cancer Cell Growth

Ying Jiao et al.

Summary: Dioscorea deltoidea leaf extract (DDLE) exerts inhibitory effects on ovarian cancer cells by reducing cell viability and promoting apoptosis, which is associated with targeting the PI3K/AKT/mTOR pathway.

DOKLADY BIOCHEMISTRY AND BIOPHYSICS (2021)

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Article Environmental Sciences

Effect of prenatal exposure to Benzo[a]pyrene on ovarian toxicity and reproductive dysfunction: Protective effect of atorvastatin in the embryonic period

Zahra Rahmani et al.

Summary: This study investigated the effects of prenatal exposure to BaP on ovarian toxicity and the protective role of ATV. Results showed that BaP induced oxidative stress and disrupted ovarian tissue structure, while ATV reduced ovarian damage and restored sex hormone levels.

ENVIRONMENTAL TOXICOLOGY (2021)

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Article Cell Biology

Pegylated Recombinant Human Arginase 1 Induces Autophagy and Apoptosis via the ROS-Activated AKT/mTOR Pathway in Bladder Cancer Cells

Zhuyun Zhao et al.

Summary: The study demonstrated the anticancer effects of BCT-100 on bladder cancer cells through mechanisms including reduction of intracellular arginine levels, induction of autophagy and apoptosis, and suppression of the AKT/mTOR signaling pathway.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Biochemistry & Molecular Biology

Oxidative Stress in Cancer Cell Metabolism

Saniya Arfin et al.

Summary: ROS play a crucial role in regulating pro-tumorigenic and anti-tumorigenic signaling pathways in cancer cells, and manipulating ROS production and regulating antioxidant defense systems can control tumor progression.

ANTIOXIDANTS (2021)

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Article Environmental Sciences

LncRNA PSMA3-AS1 promotes cell proliferation, migration, and invasion in ovarian cancer by activating the PI3K/Akt pathway via the miR-378a-3p/GALNT3 axis

Zhihong Xu et al.

Summary: In ovarian cancer, PSMA3-AS1 promotes cell proliferation, migration, and invasion by activating the PI3K/Akt pathway through regulation of the miR-378a-3p/GALNT3 axis.

ENVIRONMENTAL TOXICOLOGY (2021)

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Review Obstetrics & Gynecology

Immunology and Immune Checkpoint Inhibition in Ovarian Cancer - Current Aspects

Holger Bronger

Summary: Immunotherapies like immune checkpoint blockade have greatly improved the treatment of various diseases, but ovarian cancer has not benefited much from them. Low mutational burden, inadequate presentation of antigens, and increased infiltration of immunosuppressive cells may be reasons for this. Although response rates to PD-1/PD-L1 checkpoint inhibitors in ovarian cancer trials have been disappointingly low, isolated long-term remissions have been observed. Finding predictive biomarkers and suitable combination partners for ICB therapy is now crucial to enhance the immunogenicity of ovarian cancer or overcome immunosuppressive resistance mechanisms.

GEBURTSHILFE UND FRAUENHEILKUNDE (2021)

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Article Oncology

Selenite Induces Cell Cycle Arrest and Apoptosis via Reactive Oxygen Species-Dependent Inhibition of the AKT/mTOR Pathway in Thyroid Cancer

Zhen Cheng et al.

Summary: Sodium selenite has been demonstrated to have significant anticancer effects against thyroid cancer cells by inducing G0/G1 cell cycle arrest and apoptosis in a dose-dependent manner, possibly through ROS-mediated inhibition of the AKT/mTOR pathway.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Artemisinin Derivatives Inhibit Non-small Cell Lung Cancer Cells Through Induction of ROS-dependent Apoptosis/Ferroptosis

Qiuting Zhang et al.

Summary: Artemisinin derivatives such as artemisinin and dihydroartemisinin have shown anti-proliferative effects on non-small cell lung cancer (NSCLC) cells by inducing apoptosis and ferroptosis. These findings suggest the potential application of artemisinin derivatives as novel therapeutic drugs for NSCLC.

JOURNAL OF CANCER (2021)

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Review Cell Biology

The double dealing of cyclin D1

Guergana Tchakarska et al.

CELL CYCLE (2020)

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Article Biochemistry & Molecular Biology

HP-CagA plus Regulates the Expression of CDK4/CyclinD1 via reg3 to Change Cell Cycle and Promote Cell Proliferation

Bin Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Oncology

PARP Inhibitors as Therapeutics: Beyond Modulation of PARylation

Ahrum Min et al.

CANCERS (2020)

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Article Oncology

Bevacizumab and platinum-based combinations for recurrent ovarian cancer: a randomised, open-label, phase 3 trial

Jacobus Pfisterer et al.

LANCET ONCOLOGY (2020)

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Article Cell Biology

LAIR-1 suppresses cell growth of ovarian cancer cell via the PI3K-AKT-mTOR pathway

Yan Liu et al.

AGING-US (2020)

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Article Pharmacology & Pharmacy

Enhancing ovarian cancer conventional chemotherapy through the combination with cannabidiol loaded microparticles

A. Fraguas-Sanchez et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

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Review Oncology

Immune Checkpoint Blockade in Gynecologic Cancers: State of Affairs

Maureen L. Drakes et al.

CANCERS (2020)

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Article Oncology

Clinicopathologic significance of LAIR-1 expression in hepatocellular carcinoma

Xiaojie Wu et al.

CURRENT PROBLEMS IN CANCER (2019)

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Review Oncology

Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance

Meran Keshawa Ediriweera et al.

SEMINARS IN CANCER BIOLOGY (2019)

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Review Oncology

Reactive oxygen species and cancer: A complex interaction

Sankaralingam Saikolappan et al.

CANCER LETTERS (2019)

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Article Immunology

LAIR-1 Limits Neutrophilic Airway Inflammation

Kuldeep Kumawat et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Biochemistry & Molecular Biology

Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression

Tayaba Ismail et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Biochemistry & Molecular Biology

Cannabidiol-from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer

Brigitta Kis et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Cell Biology

Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer

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CELL DEATH & DISEASE (2019)

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Review Biochemistry & Molecular Biology

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

Vaishali Aggarwal et al.

BIOMOLECULES (2019)

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Article Oncology

Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells

Soyeon Jeong et al.

CANCER LETTERS (2019)

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Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells

Esraah Alharris et al.

Oncotarget (2019)

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Review Neurosciences

Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Delta(9)-Tetrahydrocannabinol

Douglas L. Boggs et al.

NEUROPSYCHOPHARMACOLOGY (2018)

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Article Oncology

The study of sclareol in inhibiting proliferation of osteosarcoma cells by apoptotic induction and loss of mitochondrial membrane potential (Withdrawn Publication. See vol. 31, pg. 419, 2021)

Guoqing Duan et al.

CANCER BIOMARKERS (2018)

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Review Medicine, General & Internal

Screening for Ovarian Cancer Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Jillian T. Henderson et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

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Review Oncology

Ovarian Cancer Prevention, Screening, and Early Detection Report From the 11th Biennial Ovarian Cancer Research Symposium

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INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2017)

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Leukocyte-associated immunoglobulin-like receptor-1 expressed in epithelial ovarian cancer cells and involved in cell proliferation and invasion

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

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Cannabidiol (CBD) and its analogs: a review of their effects on inflammation

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Polymeric nanoassemblies entrapping curcumin overcome multidrug resistance in ovarian cancer

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COLLOIDS AND SURFACES B-BIOINTERFACES (2015)

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Article Behavioral Sciences

Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox-Gastaut syndrome

Shaun A. Hussain et al.

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Article Pharmacology & Pharmacy

Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1

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Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis

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BREAST CANCER RESEARCH AND TREATMENT (2011)

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Article Chemistry, Multidisciplinary

Cannabidiol attenuates delayed-type hypersensitivity reactions via suppressing T-cell and macrophage reactivity

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Detection of novel leukocyte differentiation antigens on basophils and mast cells by HLDA8 antibodies

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ALLERGY (2006)

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The inhibitory leukocyte-associated Ig-like receptor-1 (LAIR-1) is expressed at high levels by human naive T cells and inhibits TCR mediated activation

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MOLECULAR IMMUNOLOGY (2005)

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A novel mechanism of cannabidiol in suppressing ovarian cancer through LAIR-1 mediated mitochondrial dysfunction and apoptosis

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