4.8 Article

Multiomics Point of Departure (moPOD) Modeling Supports an Adverse Outcome Pathway Network for Ionizing Radiation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Environmental Sciences

Comparative analysis of transcriptomic points-of-departure (tPODs) and apical responses in embryo-larval fathead minnows exposed to fluoxetine

Alper James G. Alcaraz et al.

Summary: Current approaches in chemical hazard assessment, which rely on live animal testing, face challenges due to concerns about time, cost, and ethics. This study developed a new approach using a short-term embryo assay to predict the toxicity of fluoxetine and obtained protective points-of-departure.

ENVIRONMENTAL POLLUTION (2022)

Editorial Material Biology

Adverse outcome pathway: a path toward better data consolidation and global co-ordination of radiation research

Vinita Chauhan et al.

Summary: The use of Adverse Outcome Pathway (AOP) approach in radiation research is important for assessing the risks of low dose radiation. The Rad/Chem AOP joint topical group aims to advance the use of AOPs by organizing and evaluating mechanistic knowledge, identifying research needs, and developing radiation-relevant case studies.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

Article Engineering, Environmental

High throughput data-based, toxicity pathway-oriented development of a quantitative adverse outcome pathway network linking AHR activation to lung damages

Yuan Jin et al.

Summary: This study developed a highly reliable AOP model concerning human health, validated and quantitatively evaluated it, and conducted targeted bioassays to further understand cellular responses. Through these research efforts, a comprehensive AOP network was established, providing valuable insights for risk assessment.

JOURNAL OF HAZARDOUS MATERIALS (2022)

Editorial Material Medicine, Legal

Progress towards an OECD reporting framework for transcriptomics and metabolomics in regulatory toxicology

Joshua A. Harrill et al.

Summary: Omics methodologies are widely used in toxicological research, but face challenges in gaining widespread regulatory acceptance due to lack of transparency in data processing methods and standardization in reporting. To foster further regulatory use of Omics data, the OECD's EAGMST launched a project to develop guidance for reporting Omics data.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights

Zhiqiang Pang et al.

Summary: MetaboAnalyst version 5.0 has been introduced to facilitate comprehensive metabolomics data analysis and interpretation, with the aim of narrowing the gap from raw data to functional insights. Three new modules have been developed to assist in this goal, along with various other new functions and improvements in interface, graphics, and codebase. Users can now easily switch between compatible modules for a streamlined data analysis experience.

NUCLEIC ACIDS RESEARCH (2021)

Article Biology

Why is the multiple stressor concept of relevance to radioecology?

B. Salbu et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2019)

Article Multidisciplinary Sciences

Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

Mark R. Viant et al.

NATURE COMMUNICATIONS (2019)

Article Biology

The NMBU FIGARO low dose irradiation facility

Ole Christian Lind et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2018)

Article Engineering, Environmental

DRomics: A Turnkey Tool to Support the Use of the Dose-Response Framework for Omics Data in Ecological Risk Assessment

Floriane Larras et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2018)

Article Engineering, Environmental

Benchmarking Water Quality from Wastewater to Drinking Waters Using Reduced Transcriptome of Human Cells

Pu Xia et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Article Medicine, Legal

A generic Transcriptomics Reporting Framework (TRF) for 'omics data processing and analysis

Timothy W. Gant et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2017)

Article Medicine, Legal

Framework for the quality assurance of 'omics technologies considering GLP requirements

Hans-Martin Kauffmann et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2017)

Article Medicine, Legal

The challenge of the application of 'omics technologies in chemicals risk assessment: Background and outlook

Ursula G. Sauer et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2017)

Editorial Material Medicine, Legal

Editorial: Applying 'omics technologies in chemicals risk assessment

Bennard van Ravenzwaay et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2017)

Article Medicine, Legal

Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop

Roland Buesen et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2017)

Article Food Science & Technology

Update: use of the benchmark dose approach in risk assessment

Anthony Hardy et al.

EFSA JOURNAL (2017)

Review Marine & Freshwater Biology

The biological effects of ionising radiation on Crustaceans: A review

Neil Fuller et al.

AQUATIC TOXICOLOGY (2015)

Review Biochemistry & Molecular Biology

Effects of Ionizing Radiation on Biological Molecules-Mechanisms of Damage and Emerging Methods of Detection

Julie A. Reisz et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Article Medicine, Legal

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

Knut Erik Tollefsen et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2014)

Review Environmental Sciences

Comparison of the Chernobyl and Fukushima nuclear accidents: A review of the environmental impacts

Georg Steinhauser et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2014)

Article Biotechnology & Applied Microbiology

Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: A five chemical case study

Russell S. Thomas et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2012)

Article Environmental Sciences

Effects of ionizing radiation on wildlife: What knowledge have we gained between the Chernobyl and Fukushima accidents?

Nicholas A Beresford et al.

Integrated Environmental Assessment and Management (2011)

Article Environmental Sciences

Effects of chronic external gamma irradiation on growth and reproductive success of Daphnia magna

Rodolphe Gilbin et al.

JOURNAL OF ENVIRONMENTAL RADIOACTIVITY (2008)

Article Biochemistry & Molecular Biology

High-throughput functional annotation and data mining with the Blast2GO suite

Stefan Gotz et al.

NUCLEIC ACIDS RESEARCH (2008)