期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 57, 期 3, 页码 5380-5390出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.est.2c09740
关键词
metal-organic frameworks; MOF-74-Zn; neurotoxicity; catecholamine neurotransmitters; nanomaterial safety
This study examines the impact of nanoscale metal-organic frameworks (MOFs) on neurological behaviors and neurotransmitter metabolism. The results show that exposure to MOF-74-Zn nanoparticles leads to negative behaviors and neurotransmitter metabolism disorders. This underscores the importance of understanding and safely using nanoscale metal-based MOFs.
As a group of new nanomaterials, nanoscale metal- organic frameworks (MOFs) are widely applied in the biomedical field, exerting unknown risks to the human body, especially the central nervous system. Herein, the impacts of MOF-74-Zn nanoparticles on neurological behaviors and neurotransmitter metabolism are explored in both in vivo and in vitro assays modeled by C57BL/6 mice and PC12 cells, respectively. The mice exhibit increased negative-like behaviors, as demonstrated by the observed decrease in exploring behaviors and increase in despair like behaviors in the open field test and forced swimming test after exposure to low doses of MOF-74-Zn nanoparticles. Disorders in the catecholamine neurotransmitter metabolism may be responsible for the MOF-74-Zn-induced abnormal behaviors. Part of the reason for this is the inhibition of neurotransmitter synthesis caused by restrained neurite extension. In addition, MOF-74-Zn promotes the translocation of more calcium into the cytoplasm, accelerating the release and uptake and finally resulting in an imbalance between synthesis and catabolism. Taken together, the results from this study indicate the human toxicity risks of nanoscale low-toxicity metal-based MOFs and provide valuable insight into the rational and safe use of MOF nanomaterials.
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