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Article
Engineering, Environmental
Ashish Kothari et al.
Summary: The emergence of multidrug-resistant bacteria poses a significant threat to global public health. Majority of clinical bacteria are found to be multidrug-resistant, with antibiotic resistance genes on their plasmids that can be horizontally transferred. The presence of optimal concentration of antibiotics or heavy metals facilitates horizontal gene transfer. High levels of arsenic in water were discovered in the Shukratal region of India, corresponding to high serum arsenic levels in infected individuals and increased antibiotic resistance in bacterial strains isolated from that area. This research highlights the imminent threats to global health due to improper waste disposal, increased antibiotic concentrations and human interference.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Multidisciplinary Sciences
Lu Luan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Engineering, Environmental
Xuexia Jin et al.
Summary: Antibiotic resistance genes (ARGs) can be transferred from environmental microbes to human pathogens, thus leading to bacterial infection treatment failures. Our findings showed that enrofloxacin application also increased the relative abundance of various ARGs in addition to quinolone-resistance genes and induced ARG dissemination in crayfish gut and sediment bacteria. Transposase-mediated recombination was identified as the major driver of horizontal gene transfer (HGT) of ARGs under antibiotic stress.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Entomology
Zhaoyang Hu et al.
Summary: Silkworm is an economic insect and a model organism for life science research. The disease caused by Bombyx mori nucleopolyhedrovirus (BmNPV) is a major infectious disease in the sericulture industry, causing over 60% of cocoon loss. The most effective solution is breeding disease-resistant varieties through genetic modification, but the mechanism of disease resistance needs to be understood. Researchers have found candidate genes through various techniques and obtained disease-resistant varieties through hybrid breeding, RNA interference, and genetic modification. This article reviews the research advances in silkworm resistance to BmNPV and encourages further exploration of disease resistance genes and breeding of disease-resistant silkworms.
ANNUAL REVIEW OF ENTOMOLOGY
(2023)
Article
Engineering, Environmental
Zishu Liu et al.
Summary: Soil is the major reservoir of antibiotic resistance genes (ARGs), particularly multidrug efflux pump genes, which have raised concerns due to their high prevalence in natural soil ecosystems. This study examined the influence of soil pH on the selection and composition of multidrug efflux pump genes in soil resistomes. The findings indicate that acidic soil environments significantly enrich multidrug efflux pump genes, reflecting the benefits of high soil proton activity on these genes.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Houyu Li et al.
Summary: The study found that the application of composted manure significantly increased the abundance of most ARGs and pathogens in soil, some ARGs and pathogens still existed in deep soil, total organic carbon had a significant influence on pathogen distribution, and bacterial communities primarily drove the vertical migration of ARGs.
ENVIRONMENTAL RESEARCH
(2022)
Article
Infectious Diseases
Michinobu Yoshimura et al.
Summary: We observed a newly emerged resistance to beta-lactams in a case of P. ananatis bacteremia, and whole genome sequence analysis revealed the presence of two beta-lactamase genes and related genes in the chromosome. Induction experiment confirmed the expression of class A beta-lactamase gene in the isolate.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2022)
Article
Environmental Sciences
Shi-Hua Niu et al.
Summary: Black soldier fly larvae have the ability to convert organic waste into a sustainable resource. This study found that a density of 100 larvae cultured in 100 g of manure resulted in the best elimination of antibiotic resistance genes (ARGs), although the deposition of ARGs in the larval gut increased with higher larval density. The adjustment of larval density can effectively manage the risk of ARGs during the bioconversion process of black soldier fly larvae manure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Engineering, Environmental
Benedetta Pagliaccia et al.
Summary: The recovery and conversion of Extracellular Polymeric Substances (EPS) from sewage sludge into bio-based commodities could improve the economics and environmental sustainability of wastewater treatment. The application of EPS as a biosorbent for heavy metal removal showed high adsorption capacities and diverse adsorption mechanisms, making it suitable for treating complex wastewaters.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Multidisciplinary Sciences
Zhenyan Zhang et al.
Summary: The study analyzes 4572 metagenomic samples to illustrate the global patterns of antibiotic resistance gene (ARG) distribution in diverse habitats. They quantitatively evaluate the health risk to humans of 2561 ARGs by integrating human accessibility, mobility, pathogenicity, and clinical availability. With machine learning, they map the antibiotic resistance threats in global marine habitats with over 75% accuracy.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Samuel C. Forster et al.
Summary: In this study, the researchers compared strains of commensal bacteria and pathogens and identified numerous antibiotic resistance gene transfer events mediated by mobile genetic elements. They observed that 15 mobile genetic elements with broad host range can transfer between different bacterial phyla.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Julia Langeder et al.
Summary: MDAAs derived from the white mulberry tree have been discovered as dual inhibitors of influenza viruses and pneumococci. The study aimed to identify the most prolific natural source of MDAAs, develop a protocol to maximize their content in Morus alba extracts, unravel constituents with high anti-infective potential, and select a hit extract as a candidate for further studies. Analysis revealed that root bark was the best starting material and pressurized liquid extraction was the optimum technique for extraction. The hit extract showed good tolerance by lung cells and potent in vitro activities against influenza viruses, S. pneumoniae, S. aureus, and inflammation.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Environmental Sciences
Yangqing Wang et al.
Summary: This study reveals the presence of abundant antibiotics and antibiotic resistance genes in landfills and landfill leachate, posing a significant threat to the environment. The study focuses on the seasonal variation of three specific antibiotic resistance genes (sulI, tetO, and tetW) in Chinese municipal solid waste landfill leachates over two years. The study also identifies the bacterial hosts of these resistance genes and evaluates their risk levels. The results demonstrate the high health risk associated with antibiotic resistance in landfills, particularly in genes that are abundant in the human-associated environment, have gene mobility, and possess pathogenicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Sonia Gupta et al.
Summary: The study investigates the relationship between heavy metal pollution and antibiotic resistance in river systems. The results indicate that high metal concentrations promote the abundance of metal and antibiotic resistance genes and affect bacterial communities, leading to the development of multi-metal and multi-antibiotic resistance. Network analysis demonstrates the positive relationships between metal resistance genes and antibiotic resistance genes, as well as the potential role of integrons in the co transmission of these genes. The findings highlight the need to consider metal pollution in controlling antibiotic resistance transmission.
ENVIRONMENTAL POLLUTION
(2022)
Article
Ecology
Xinzhu Yi et al.
Summary: Mining activities have significant environmental impacts and can co-select for antibiotic resistance genes (ARGs) in microorganisms. However, ARGs in mining-impacted environments are poorly understood. In this study, a comprehensive investigation of ARGs in globally distributed mining sites was conducted. The results showed that the total abundance of ARGs in these sites was comparable to urban sewage but higher than freshwater sediments. Multidrug resistance genes accounted for a substantial portion of the total ARG abundance and tended to co-occur with multimetal resistance genes. Additionally, high-quality ARG-carrying genomes were identified, expanding the phylogenetic diversity of ARG hosts and revealing potential pathogens. These findings suggest that mining-impacted environments are important reservoirs of multidrug resistance genes.
Article
Environmental Sciences
Tanghuan Xie et al.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Norman Hembach et al.
Summary: Manure from swine livestock contains pathogenic bacteria and resistance genes against veterinary and clinically critical antibiotics, posing potential health risks. Comparative measurements of manure and hospital wastewater show the presence of facultative pathogens and critical resistance genes, indicating a risk for the dissemination of these genes.
ENVIRONMENTAL POLLUTION
(2022)
Article
Engineering, Environmental
Haining Huang et al.
Summary: This study demonstrated for the first time that reductive stress can significantly enhance the horizontal transfer of plasmids between bacteria, providing an updated regulatory mechanism for plasmid conjugation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Lin Zhu et al.
Summary: Concerns about biological risk in the environment have been increasing. Manure has been considered a significant source of antibiotic resistance genes (ARGs) in agricultural soil. However, the extent of microbial contamination in different manure-amended soils, including ARGs, virulence factor genes (VFGs), and human bacterial pathogens (HBPs), remains largely unknown. This study used a metagenome-based approach to investigate changes in resistome, VFGs, and HBPs in soils treated with commonly used manures. The results showed that ARGs, VFGs, and HBPs from manure could be spread into soils, and their diversity and abundance varied significantly depending on the type of manure used. The study also found a positive co-occurrence pattern between ARGs and HBPs, VFGs and HBPs, as well as ARGs and VFGs. Pig manure and silkworm excrement samples had higher levels of microbial contamination compared to other samples, suggesting that the use of these two manures increased the risk of HBPs and the dissemination of ARGs. This study confirms the prevalence and differences in resistome, VFGs, and HBPs in different manure-amended soils.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Engineering, Environmental
Hai Huang et al.
Summary: This review introduces carbon-based materials and clay minerals as efficient adsorbents for removing antibiotic resistance genes (ARGs) under heavy metal stress. The crucial factors affecting gene variations are summarized, and the mechanisms of gene removal by these materials under the influence of these factors are proposed. The pathways of reducing genes by these materials through reducing heavy metal co-selection and altering microbial communities under heavy metal stress are emphasized. The bottlenecks of research on reducing genes by these adsorbents and future research directions are described in detail.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Environmental Sciences
Qiang Pu et al.
Summary: The study found that sub-inhibitory cadmium contamination significantly increased plasmid transfer frequency in aquatic bacterial communities, suggesting that cadmium may facilitate plasmid conjugation.
ENVIRONMENTAL POLLUTION
(2021)
Article
Ecology
Guibing Zhu et al.
Summary: The study found widespread presence of antibiotic resistance genes (ARGs) in fresh snow, and their dissemination may be exacerbated by air pollution. Snowfall effectively spreads ARGs from point sources to the Earth's surface, highlighting the need for better pollution control measures to reduce the global dissemination risk of antibiotic resistance genes.
Article
Environmental Sciences
Olivia Ginn et al.
Summary: This study investigated the presence of antibiotic resistance genes (ARGs) and mobile integrons (MIs) in the urban air of La Paz, Bolivia. The study found that areas close to wastewater flows had higher concentrations of ARGs, while the density of ARGs decreased with increasing distance from impacted surface waters.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Andrea Laconi et al.
Summary: The study found that manure application has a minor effect on soil microbiome but may contribute to the spread of specific antimicrobial resistance genes (ARGs) in the environment. Some antimicrobial concentrations increased slightly after manure application, with specific ARGs significantly enriched in fertilized soil.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Engineering, Environmental
Yuezhao Li et al.
Summary: This study demonstrated that heavy metal enrichment has significant effects on sediment microbiomes, antibiotic resistance genes, and metal resistance genes. Source apportionment and a modified risk model showed that human activities primarily contribute to the ecological risks of metals in urban rivers.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Ecology
Anna E. Dewar et al.
Summary: The study indicates that while horizontal gene transfer may aid in the initial invasion of cooperative genes in a population, it has less influence on the long-term maintenance of cooperation. Furthermore, genes for extracellular proteins are more likely to be carried on plasmids when they encode pathogenic virulence traits, particularly in pathogenic bacteria with a broad host range.
NATURE ECOLOGY & EVOLUTION
(2021)
Article
Biochemical Research Methods
Jillian Silbert et al.
Summary: In this study, the conjugation machinery of the RP4 plasmid was recruited into a synthetic construct using yeast assembly, enabling the transfer of chromosomal segments between P. putida KT2440 and other Gram-negative bacteria. This new device expands the molecular toolbox for P. putida and allows for genomic manipulations previously only possible with laboratory strains and species.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Environmental Sciences
Biyensa Gurmessa et al.
Summary: This study found that cattle manure has a greater abundance of antibiotic resistance genes compared to poultry litter, with strong relationships between the physiochemical properties and bacterial diversity.
ENVIRONMENTAL RESEARCH
(2021)
Article
Engineering, Environmental
Han Xu et al.
Summary: The study showed that soil bacteria, especially Proteobacteria, might capture RP4 from E. coli and then translocate into the plant microbiome, resulting in increased RP4 plasmid spread in plant endophytes.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Meirong Song et al.
Summary: This study demonstrates the potential of natural flavonoids from plants against multidrug resistant bacteria, with a focus on the structure-activity relationship analysis of two compounds, alpha-mangostin and isobavachalcone. These compounds show rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, and mechanism studies suggest they target bacterial membrane phospholipids. The efficacy of these natural products in infection or contamination models highlights them as a promising and underappreciated resource for combating antibiotic resistance.
Article
Environmental Sciences
Lin Zhu et al.
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Environmental Sciences
Qing Wang et al.
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Environmental Sciences
Changchun Yan et al.
ENVIRONMENTAL RESEARCH
(2020)
Article
Soil Science
Silu Sun et al.
SOIL BIOLOGY & BIOCHEMISTRY
(2020)
Article
Environmental Sciences
Huiru Zhao et al.
ENVIRONMENTAL POLLUTION
(2020)
Article
Environmental Sciences
Renwei Feng et al.
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Engineering, Environmental
Erica R. Fuhrmeister et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2019)
Article
Environmental Sciences
Feng Li et al.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2019)
Article
Environmental Sciences
Francisco Cerqueira et al.
ENVIRONMENTAL RESEARCH
(2019)
Review
Infectious Diseases
Terence Lee et al.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2019)
Article
Chemistry, Applied
Emmanuel Kwaw et al.
Article
Environmental Sciences
Xiaoming Wan et al.
SCIENCE OF THE TOTAL ENVIRONMENT
(2017)
Article
Computer Science, Artificial Intelligence
Jennifer Lu et al.
PEERJ COMPUTER SCIENCE
(2017)
Article
Biotechnology & Applied Microbiology
Pieter De Maayer et al.
