Human health risks and hepatotoxicity associated with exposure to atrazine surveyed in drinking water from Ijebu-North, Southwest, Nigeria

No recognized study has been conducted in rural agricultural areas in Nigeria to monitor atrazine in drinking water and its potential health implications. Here, a total of 69 hand-dug wells (HDW), 40 boreholes (BH), and 4 streams were collected from the six (6) communities in Ijebu-North Local Government Area, Southwest Nigeria and analyzed for atrazine residue using gas chromatography-mass spectrometry (GC-MS). Values of atrazine obtained were further used to evaluate the non-carcinogenic risk associated with ingestion and dermal routes in children and adults using the standard US EPA protocols. Sub-chronic hepatotoxicity of the atrazine residue in the water sample was assessed using standard methods. A total of 41 HDW, 22 BH, and the 4 streams tested positive for atrazine. The highest concentration of atrazine recorded in the HDW water from Ijebu-North ranged from 0.01 to 0.08 mg/L. Hazard index (HI) values associated with the exposure routes in both adults and children were less than 1 for all the communities. Although atrazine at 0.01, 0.03, and 0.04 mg/L concentrations appear to trigger defense mechanisms capable of protecting the structural integrity of the liver, significant (p < 0.05) changes in hepatic markers, oxidative stress parameters, mixed-function oxygenases, ATPase enzymes, and mild structural lesions were seen in the liver of rats exposed to atrazine at 0.08 mg/L. Atrazine at 0.01, 0.03, and 0.04 mg/L concentrations found in water from Ijebu-North may not pose any threat to liver function, but concern should be raised at 0.08 mg/L.

Automated summary

This study conducted in rural agricultural areas of Nigeria for the first time monitored the presence of atrazine in drinking water and its potential health implications. It was found that some of the tested wells and streams contained atrazine, but the current concentrations of atrazine in the water sources pose acceptable non-carcinogenic risks for both adults and children.