期刊
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
卷 28, 期 6, 页码 1014-1022出版社
SOC BRASILEIRA QUIMICA
DOI: 10.21577/0103-5053.20160255
关键词
Plectranthus ornatus; diterpenes; ent-clerodanes; bacteriostatic
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Pessoal e Nivel Superior (CAPES)
- Programa de Nucleo de Excelencia (PRONEX)
Five new diterpenes derivatives named as ornatin A, B, C, D and E, in addition to six known related diterpenes were isolated from the aerial parts of cultivated specimens of Plectranthus ornatus. The structures were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HRESIMS) and comparison with published NMR data of analogous compounds. All isolated compounds were assayed against four human cancer cell lines, and Gram-positive and Gram-negative bacteria strains. None of them showed any cytotoxic activity, but ornatin C, D, E and three related diterpenes displayed marginal bactericidal or bacteriostatic effects against the Gram-positive strains.
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