☆ 4.4 Review

The Unique Importance of Differentiation and Function in Endocrine Neoplasia

ENDOCRINE PATHOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Cell Biology

Primary high-grade non-anaplastic thyroid carcinoma: a retrospective study of 364 cases

Bin Xu et al.

Summary: This study found that high-grade non-anaplastic thyroid carcinomas (HGTC) can be classified into two distinct subtypes, HGTC-PDTC and HGTC-nonPDTC, based on clinicopathological and molecular features. Factors such as age, gender, tumor characteristics, and molecular alterations have significant impact on prognosis, with the coexistence of BRAF V600E and TERT increasing the risk of metastasis.

HISTOPATHOLOGY (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Overview of the 2022 WHO Classification of Thyroid Neoplasms

Zubair W. Baloch et al.

Summary: This review summarizes the changes in the 5th edition of the WHO Classification of Endocrine and Neuroendocrine Tumors that relate to the thyroid gland. The new classification provides a more detailed understanding of the different types of thyroid tumors based on their cell of origin, pathologic features, molecular profiles, and biological behavior. It also introduces new categories, such as thyroid follicular nodular disease, non-invasive follicular thyroid neoplasm with papillary-like nuclear features, and high-grade differentiated thyroid carcinomas. The classification emphasizes the importance of biomarkers in diagnosis and prognosis.

ENDOCRINE PATHOLOGY (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Overview of the 2022 WHO Classification of Pituitary Tumors

Sylvia L. Asa et al.

Summary: This review summarizes the changes in the 5th Edition of the WHO Classification of Endocrine and Neuroendocrine Tumors related to the pituitary gland, including the classification of pituitary lobe tumors and the detailed subtyping based on tumor cell lineage, cell type, and characteristics.

ENDOCRINE PATHOLOGY (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Overview of the 2022 WHO Classification of Neuroendocrine Neoplasms

Guido Rindi et al.

Summary: In this review, the changes and features of neuroendocrine neoplasms (NENs) in the 2022 WHO Classification of Endocrine and Neuroendocrine Tumors are detailed. The consolidation of nomenclature distinguishing different neoplasms and the importance of Ki67 as a tool for classification and grading are emphasized. The clinical relevance of proper classification and the tools available to pathologists for accurate classification are explained. The article also discusses the differential diagnoses and theranostic biomarkers for NENs, as well as the role of pathologists in identifying precursor lesions and applying molecular immunohistochemistry.

ENDOCRINE PATHOLOGY (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas

Ozgur Mete et al.

Summary: This review provides a comprehensive overview of the classification, pathogenesis, biomarkers, and diagnostic criteria of tumors of the adrenal medulla and extra-adrenal paraganglia. It also introduces new genetic predisposition syndromes and changes in tumor nomenclature.

ENDOCRINE PATHOLOGY (2022)

添加到收藏夹

Review Medicine, General & Internal

Circulating Neuroendocrine Tumor Biomarkers: Past, Present and Future

Pawel Komarnicki et al.

Summary: Neuroendocrine tumors are a diverse group of tumors originating from the endocrine system, with varying clinical presentations, prognosis, and treatment depending on their location and hormonal status. Functional tumors can be diagnosed using monoanalytes, while no universal biomarkers have been established for non-functional tumors. Previously researched substances lack desired sensitivity and specificity, but circulating tumor cells and multianalytes offer more accurate diagnostic parameters. Despite promising results, there are currently no international standards for their routine use and clinical application.

JOURNAL OF CLINICAL MEDICINE (2022)

添加到收藏夹

Article Endocrinology & Metabolism

2022 ETA Consensus Statement: What are the indications for post-surgical radioiodine therapy in differentiated thyroid cancer?

Furio Pacini et al.

Summary: The use of post-operative RAI treatment for DTC should be based on patient's risk stratification. While the benefits of radioiodine are clear for high-risk patients, its use in intermediate-risk and some low-risk patients remains controversial. New guidelines have been developed, taking into consideration retrospective data and the results of prospective randomized trials, to address questions regarding patient selection, RAI activity, and pre-treatment patient preparation.

EUROPEAN THYROID JOURNAL (2022)

添加到收藏夹

Article Endocrinology & Metabolism

International Histopathology Consensus for Unilateral Primary Aldosteronism

Tracy Ann Williams et al.

Summary: The HISTALDO consensus is useful to standardize nomenclature and achieve consistency among pathologists for the histopathologic diagnosis of unilateral PA. CYP11B2 immunohistochemistry should be incorporated into the routine clinical diagnostic workup to localize the likely source of aldosterone production.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Genomics of High-Grade Neuroendocrine Neoplasms: Well-Differentiated Neuroendocrine Tumor with High-Grade Features (G3 NET) and Neuroendocrine Carcinomas (NEC) of Various Anatomic Sites

Silvia Uccella et al.

Summary: This study redefines high-grade neuroendocrine neoplasms (HG-NENs) by discussing neuroendocrine carcinoma and high proliferating well-differentiated neuroendocrine tumors, providing new diagnostic and therapeutic tools. It systematically analyzes the genomic landscape of HG NENs in various anatomical sites, including common thoracic and digestive locations, as well as rare sites like the skin, head and neck, and urogenital system.

ENDOCRINE PATHOLOGY (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Molecular Pathology of Well-Differentiated Gastro-entero-pancreatic Neuroendocrine Tumors

Sylvia L. Asa et al.

Summary: Well-differentiated neuroendocrine tumors commonly occur in the gastrointestinal and pancreaticobiliary system, with molecular studies pointing to genetic mutations and involvement of epigenetic regulators. Treatment approaches focus on the neuroendocrine nature of the tumors and targeting specific alterations.

ENDOCRINE PATHOLOGY (2021)

添加到收藏夹

Review Endocrinology & Metabolism

Oncocytic Change in Thyroid Pathology

Sylvia L. Asa et al.

Summary: Oncocytes are cells with abundant eosinophilic cytoplasm due to mitochondrial accumulation, commonly seen in thyroid disorders and tumors. Molecular alterations in oncocytic thyroid tumors resemble non-oncocytic tumors but also involve mitochondrial DNA mutations and chromosomal gains/losses, emphasizing the importance of recognizing these pathological changes for accurate diagnosis and prognosis in patients.

FRONTIERS IN ENDOCRINOLOGY (2021)

添加到收藏夹

Review Pathology

Pituitary neuroendocrine tumors: a model for neuroendocrine tumor classification

Sylvia L. Asa et al.

Summary: The classification of adenohypophysial neoplasms as pituitary neuroendocrine tumors (PitNETs) reflects their characteristics as epithelial neuroendocrine neoplasms with a spectrum of clinical behaviors. Tumor growth and hormone hypersecretion can cause significant morbidity and mortality in patients. The intense study of PitNETs has provided important information about the importance of cellular differentiation in tumor prognosis.

MODERN PATHOLOGY (2021)

添加到收藏夹

Review Medicine, General & Internal

An Update on Pituitary Neuroendocrine Tumors Leading to Acromegaly and Gigantism

Sylvia L. Asa et al.

Summary: Excess growth hormone causes gigantism and acromegaly, which are characterized by accelerated growth and overgrowth of soft tissue and bone. Pituitary neuroendocrine tumors (PitNETs) that produce GH are primarily derived from PIT1-lineage cells, with various pathologic features. These tumors may vary in hormone production and lineage differentiation, resulting in GH excess.

JOURNAL OF CLINICAL MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Immunohistochemical Analysis of CYP11B2, CYP11B1 and β-catenin Helps Subtyping and Relates With Clinical Characteristics of Unilateral Primary Aldosteronism

Luyan Sun et al.

Summary: The study found that CYP11B2 immunostaining could improve the differential diagnosis of unilateral hyperaldosteronism, and the adjusted CYP11B2 H-score reflects the severity of APA. Furthermore, abnormal beta-catenin staining was associated with various clinical indicators, suggesting that the Wnt pathway may be a potential therapeutic target in the treatment of hyperaldosteronism.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

添加到收藏夹

Review Endocrinology & Metabolism

New perspectives for mitotane treatment of adrenocortical carcinoma

S. Puglisi et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

添加到收藏夹

Review Endocrinology & Metabolism

MANAGEMENT OF ENDOCRINE DISEASE Cushing's syndrome due to ectopic ACTH secretion: an expert operational opinion

Jacques Young et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2020)

添加到收藏夹

Article Peripheral Vascular Disease

Genetic, Cellular, and Molecular Heterogeneity in Adrenals With Aldosterone-Producing Adenoma

Kelly De Sousa et al.

HYPERTENSION (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Dissecting Anaplastic Thyroid Carcinoma: A Comprehensive Clinical, Histologic, Immunophenotypic, and Molecular Study of 360 Cases

Bin Xu et al.

THYROID (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Steroid metabolites for diagnosing and predicting clinicopathological features in cortisol-producing adrenocortical carcinoma

Sawako Suzuki et al.

BMC ENDOCRINE DISORDERS (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Diabetes in Patients With Pancreatic Neuroendocrine Neoplasms

Xiaoling Zhuge et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Biochemically Silent Sympathetic Paraganglioma, Pheochromocytoma, or Metastatic Disease in SDHD Mutation Carriers

Koen M. A. Dreijerink et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2019)

添加到收藏夹

Review Oncology

Diagnosis and pathologic characteristics of medullary thyroid carcinoma-review of current guidelines

C. M. Thomas et al.

CURRENT ONCOLOGY (2019)

添加到收藏夹

Article Endocrinology & Metabolism

The Clinicopathological Spectrum of Parathyroid Carcinoma

Amit Akirov et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

添加到收藏夹

Article Medicine, Research & Experimental

In situ metabolomics of aldosterone-producing adenomas

Masanori Murakami et al.

JCI INSIGHT (2019)

添加到收藏夹

Review Endocrinology & Metabolism

Immunohistochemical Biomarkers of Adrenal Cortical Neoplasms

Ozgur Mete et al.

ENDOCRINE PATHOLOGY (2018)

添加到收藏夹

Review Endocrinology & Metabolism

Immunohistochemical Biomarkers in Thyroid Pathology

Zubair Baloch et al.

ENDOCRINE PATHOLOGY (2018)

添加到收藏夹

Review Endocrinology & Metabolism

Immunohistochemical Biomarkers of Gastrointestinal, Pancreatic, Pulmonary, and Thymic Neuroendocrine Neoplasms

Silvia Uccella et al.

ENDOCRINE PATHOLOGY (2018)

添加到收藏夹

Review Pathology

Endocrine pathology: past, present and future

Sylvia L. Asa et al.

PATHOLOGY (2018)

添加到收藏夹

Article Endocrinology & Metabolism

Cervical Lymph Node Fine-Needle Aspiration and Needle-Wash Thyroglobulin Reflex Test for Papillary Thyroid Carcinoma

Xiaotun Zhang et al.

ENDOCRINE PATHOLOGY (2018)

添加到收藏夹

Article Pathology

A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal

Guido Rindi et al.

MODERN PATHOLOGY (2018)

添加到收藏夹

Article Endocrinology & Metabolism

Pancreatic Neuroendocrine Tumor Producing Insulin and Vasopressin

Omalkhaire M. Alshaikh et al.

ENDOCRINE PATHOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Preoperative serum thyroglobulin predicts initial distant metastasis in patients with differentiated thyroid cancer

Hosu Kim et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Review Endocrinology & Metabolism

Calcitonin-Producing Neuroendocrine Neoplasms of the Pancreas: Clinicopathological Study of 25 Cases and Review of the Literature

Silvia Uccella et al.

ENDOCRINE PATHOLOGY (2017)

添加到收藏夹

Article Surgery

The American Association of Endocrine Surgeons Guidelines for Definitive Management of Primary Hyperparathyroidism

Scott M. Wilhelm et al.

JAMA SURGERY (2016)

添加到收藏夹

Article Endocrinology & Metabolism

Catecholamine-Synthesizing Enzymes Are Expressed in Parasympathetic Head and Neck Paraganglioma Tissue

Thamara E. Osinga et al.

NEUROENDOCRINOLOGY (2015)

添加到收藏夹

Article Gastroenterology & Hepatology

Elevated Pancreatic Polypeptide Levels in Pancreatic Neuroendocrine Tumors and Diabetes Mellitus Causation or Association?

Jessica E. Maxwell et al.

PANCREAS (2014)

添加到收藏夹

Review Endocrinology & Metabolism

Somatostatin receptors: From signaling to clinical practice

Marily Theodoropoulou et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2013)

添加到收藏夹

Letter Cell Biology

Morphological distinction of cortisol-producing and aldosterone-producing adrenal cortical adenomas: not only possible but a critical clinical responsibility

Ozgur Mete et al.

HISTOPATHOLOGY (2012)

添加到收藏夹

Article Pathology

Poorly differentiated thyroid carcinoma: The Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach

Marco Volante et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2007)

添加到收藏夹

Review Oncology

Pathogenetic mechanisms in thyroid follicular-cell neoplasia

T Kondo et al.

NATURE REVIEWS CANCER (2006)

添加到收藏夹

Article Oncology

Poorly differentiated thyroid carcinomas defined on the basis of mitosis and necrosis - A clinicopathologic study of 58 patients

D Hiltzik et al.

CANCER (2006)

添加到收藏夹

Article Endocrinology & Metabolism

PAX8, TITF1, and FOXE1 gene expression patterns during human development: New insights into human thyroid development and thyroid dysgenesis-associated malformations

SS Trueba et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.