4.8 Article

ATP-induced conformational change of axonemal outer dynein arms revealed by cryo-electron tomography

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

UCSF ChimeraX: Structure visualization for researchers, educators, and developers

Eric F. Pettersen et al.

Summary: UCSF ChimeraX is a powerful visualization program with enhanced performance and graphics, offering new tools and analysis features, support for various areas like virtual reality, and improved ease of use, along with an app store for researchers to contribute new tools.

PROTEIN SCIENCE (2021)

Article Multidisciplinary Sciences

Structure of a microtubule-bound axonemal dynein

Travis Walton et al.

Summary: Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating, but the mechanisms regulating their localization and function are poorly understood. Authors report a cryo-EM reconstruction of a three-headed axonemal dynein natively bound to doublet microtubules isolated from cilia, providing a framework to understand the roles of individual subunits.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Shulin packages axonemal outer dynein arms for ciliary targeting

Girish R. Mali et al.

Summary: The protein Shulin binds to ODAs in the cytoplasm, inhibits their motor activity, stabilizes their compact form, and facilitates their delivery to the cilia, providing a molecular explanation for the process.

SCIENCE (2021)

Article Biochemistry & Molecular Biology

Remodeling and activation mechanisms of outer arm dyneins revealed by cryo-EM

Shintaroh Kubo et al.

Summary: Cilia are thin microtubule-based protrusions found in eukaryotic cells, responsible for propelling the movement of ciliated protists and sperm cells, as well as facilitating mucus flow in the trachea to protect the human body from viral infections. The main force generators of ciliary beating are the outer dynein arms (ODAs), which attach to the doublet microtubules and induce bending through conformational changes driven by ATP hydrolysis. The structure of the native ODA complex attached to the doublet microtubule has been revealed through cryo-electron microscopy, showing how the ODA complex is attached to the doublet microtubule via the docking complex in its native state, leading to remodeling and activation.

EMBO REPORTS (2021)

Article Biochemistry & Molecular Biology

Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism

Qinhui Rao et al.

Summary: Outer-arm dyneins assemble in large arrays on the ciliary axoneme to drive rhythmic beating. Cryo-EM structures of microtubule-bound Tetrahymena thermophila OAD arrays reveal the complex assembly details and propose a model for coordinated action mechanism. Thousands of outer-arm dyneins are arranged in the axoneme to generate mechanical forces for ciliary beat, with coordination among multiple dyneins being essential.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

Article Cell Biology

LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes

Zaw Min Htet et al.

NATURE CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Structure of the Decorated Ciliary Doublet Microtubule

Meisheng Ma et al.

Article Cell Biology

Axonemal Dynein Arms

Stephen M. King

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)

Article Multidisciplinary Sciences

Structure of human cytoplasmic dynein-2 primed for its power stroke

Helgo Schmidt et al.

NATURE (2015)

Article Cell Biology

Structural mechanism of the dynein power stroke

Jianfeng Lin et al.

NATURE CELL BIOLOGY (2014)

Article Cell Biology

The MIA complex is a conserved and novel dynein regulator essential for normal ciliary motility

Ryosuke Yamamoto et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

Sjors H. W. Scheres

JOURNAL OF STRUCTURAL BIOLOGY (2012)

Article Cell Biology

Association of Lis1 with outer arm dynein is modulated in response to alterations in flagellar motility

Panteleimon Rompolas et al.

MOLECULAR BIOLOGY OF THE CELL (2012)

Article Multidisciplinary Sciences

The 2.8 Å crystal structure of the dynein motor domain

Takahide Kon et al.

NATURE (2012)

Article Multidisciplinary Sciences

Structural Basis for Microtubule Binding and Release by Dynein

William B. Redwine et al.

SCIENCE (2012)

Article Biochemistry & Molecular Biology

X-ray structure of a functional full-length dynein motor domain

Takahide Kon et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)

Article Multidisciplinary Sciences

Crystal Structure of the Dynein Motor Domain

Andrew P. Carter et al.

SCIENCE (2011)

Article Biochemical Research Methods

Features and development of Coot

P. Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Article Biochemistry & Molecular Biology

Nucleotide-induced global conformational changes of flagellar dynein arms revealed by in situ analysis

Tandis Movassagh et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

AAA plus Ring and Linker Swing Mechanism in the Dynein Motor

Anthony J. Roberts et al.

Article Multidisciplinary Sciences

Dynein pulls microtubules without rotating its stalk

Hironori Ueno et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Structure and Functional Role of Dynein's Microtubule-Binding Domain

Andrew P. Carter et al.

SCIENCE (2008)

Article Biochemistry & Molecular Biology

The architecture of outer dynein arms in situ

Takashi Ishikawa et al.

JOURNAL OF MOLECULAR BIOLOGY (2007)

Article Multidisciplinary Sciences

The molecular architecture of axonemes revealed by cryoelectron tomography

Daniela Nicastro et al.

SCIENCE (2006)

Article Biochemistry & Molecular Biology

Automated electron microscope tomography using robust prediction of specimen movements

DN Mastronarde

JOURNAL OF STRUCTURAL BIOLOGY (2005)

Article Cell Biology

Proteomic analysis of a eukaryotic cilium

GJ Pazour et al.

JOURNAL OF CELL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Software extensions to UCSF Chimera for interactive visualization of large molecular assemblies

TD Goddard et al.

STRUCTURE (2005)

Article Biochemistry & Molecular Biology

Bsoft: Image and molecular processing in electron microscopy

JB Heymann

JOURNAL OF STRUCTURAL BIOLOGY (2001)