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Nanocarriers overcoming biological barriers induced by multidrug resistance of chemotherapeutics in 2D and 3D cancer models

DRUG RESISTANCE UPDATES (2023)

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Article Engineering, Biomedical

Cascade-responsive nano-assembly for efficient photothermal-chemo synergistic inhibition of tumor metastasis by targeting cancer stem cells

Xianqi Zhu et al.

Summary: In this study, a smart photothermal-chemo therapeutic nano-assembly system was developed to target cancer stem cells (CSCs). By modifying the surface of the nano-assembly, the physiological barriers for CSC targeting were overcome. The nano-assembly effectively eliminated both CSCs and non-CSCs, inhibiting tumor growth and metastasis.

BIOMATERIALS (2022)

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Article Engineering, Environmental

Homotypic biomimetic coating synergizes chemo-photothermal combination therapy to treat breast cancer overcoming drug resistance

Kai Guo et al.

Summary: The smart drug delivery system combines biomimetic coating, magnetic targeting, homotypic targeting, and triggered release properties to enhance drug accumulation within cancer cells, resulting in significant tumor growth inhibition.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Cell Biology

Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy

Xuanhua P. Xie et al.

Summary: This study confirms the existence of quiescent cancer stem cells in glioblastoma that can evade anti-proliferative therapies. By analyzing the functional characteristics of glioblastomas from genetically engineered mice, essential quiescent stem-like cells that can be directly isolated from tumors were identified. A specific gene expression signature related to quiescent cancer stem cells was found in both primary and recurrent human glioblastomas. These findings provide insights into the failure of conventional treatment and lay the foundation for alternative therapies.

DEVELOPMENTAL CELL (2022)

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Article Cell Biology

Pharmacological or genetic inhibition of hypoxia signaling attenuates oncogenic RAS-induced cancer phenotypes

Jun-yi Zhu et al.

Summary: This study investigates the role of oncogenic Ras proteins in acute myeloid leukemia using a Drosophila model. Through genetic and drug screens, the researchers identify candidate genes and a potential targeted drug, echinomycin, that can attenuate oncogenic Ras-induced cancer phenotypes. The study suggests that inhibiting the hypoxia pathway could be an effective treatment approach.

DISEASE MODELS & MECHANISMS (2022)

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Article Pharmacology & Pharmacy

GSH-responsive poly-resveratrol based nanoparticles for effective drug delivery and reversing multidrug resistance

Yang Liping et al.

Summary: This study reports the synthesis of a GSH-responsive polymer that exhibits anti-cancer effects, high drug loading capacity, and the ability to overcome multidrug resistance. The polymer is capable of self-assembling into nanoparticles for efficient drug delivery. In vitro and in vivo experiments demonstrate the potential of this system for cancer treatment.

DRUG DELIVERY (2022)

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Article Chemistry, Physical

Stimuli-responsive charge-reversal MOF@polymer hybrid nanocomposites for enhanced co-delivery of chemotherapeutics towards combination therapy of multidrug-resistant cancer

Liefeng Hu et al.

Summary: Combination chemotherapy using metal-organic framework (MOF)-based polymer-coated hybrid nanoparticles (NPs) holds promise for treating multidrug-resistant cancer by enhancing the delivery of multiple drugs into tumor cells.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Mitochondria-targeted polymer-celastrol conjugate with enhanced anticancer efficacy

Yu Geng et al.

Summary: This study presents a drug delivery system using a block copolymer as a carrier for celastrol, a natural anticancer compound. The system can self-assemble into nanoparticles and has improved pharmacokinetics and efficient mitochondria targeting capacity, enhancing the therapeutic effects of celastrol in cancer treatment.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Materials Science, Biomaterials

A self-amplified ROS-responsive chemodrug-inhibitor conjugate for multi-drug resistance tumor therapy

Tingting Sun et al.

Summary: In this study, a self-amplified ROS-responsive co-delivery system was constructed by conjugating tamoxifen with d-alpha-tocopherol polyethylene glycol1000 succinate based on a reactive oxygen species (ROS)-responsive bond. The system showed enhanced antitumor effect and reversed multidrug resistance in cancer cells.

BIOMATERIALS SCIENCE (2022)

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Article Instruments & Instrumentation

Synergistic antitumor efficacy of PD-1-conjugated PTX-and ZSQ-loaded nanoliposomes against multidrug-resistant liver cancers

Mingjia Gu et al.

Summary: In this study, a PD-L1-conjugated nanoliposome was developed for the treatment of hepatocellular carcinoma (HCC). The nanoliposome showed high drug loading capacity, significant synergistic effects, and promising antitumor efficacy.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Review Oncology

3D Cell Culture Models as Recapitulators of the Tumor Microenvironment for the Screening of Anti-Cancer Drugs

Melanie A. G. Barbosa et al.

Summary: Three-dimensional (3D) cell culture models are proposed as alternatives for initial drug screening to increase drug development efficiency. These models can reproduce key aspects of the tumor microenvironment and reduce the use of laboratory animals, in accordance with the 3R principles. This review discusses the impact of 3D models on cancer research, their advantages and limitations, as well as their compatibility with high-throughput screenings and automated systems. It also emphasizes the importance of incorporating key microenvironmental cues for improved predictive value of drug efficacy.

CANCERS (2022)

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Article Pharmacology & Pharmacy

A Nanosized Codelivery System Based on Intracellular Stimuli-Triggered Dual-Drug Release for Multilevel Chemotherapy Amplification in Drug-Resistant Breast Cancer

Yufan Guo et al.

Summary: Lack of precise nano-systems for co-delivering chemotherapeutics and inhibitors greatly reduces the anticancer effects in multidrug resistant tumors. This study constructed hybrid polymeric nanoparticles that can be internalized into drug-resistant cancer cells and release drugs intracellularly, achieving multilevel chemotherapy amplification.

PHARMACEUTICS (2022)

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Article Engineering, Biomedical

Stimuli-responsive, dual-function prodrug encapsulated in hyaluronic acid micelles to overcome doxorubicin resistance

Lipeng Qiu et al.

Summary: A dual-functional pH-sensitive drug delivery system was developed for breast cancer therapy. The system showed higher cytotoxicity and cell uptake efficiency compared to other drug-loaded micelles, indicating its potential for reversing multidrug resistance. In vivo experiments demonstrated that the system effectively inhibited tumor growth without significant changes in body weight. The results suggest that the dual gain DNVM can enhance the efficacy of chemotherapy for doxorubicin-resistant tumor cells and has the potential to overcome multiple drug resistance.

ACTA BIOMATERIALIA (2022)

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Review Immunology

The therapeutic implications of immunosuppressive tumor aerobic glycolysis

Bradley I. Reinfeld et al.

Summary: The new hallmarks of cancer relating to metabolism have shown that tumor cells not only benefit from altered cellular energetics, but also create an immunosuppressive microenvironment that promotes their own growth and progression. Development of therapies targeting cancer metabolism needs to carefully consider the balance between inhibiting tumor growth and preserving antitumor immunity.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

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Article Cell Biology

Induction of autophagy-dependent ferroptosis to eliminate drug-tolerant human retinoblastoma cells

Ke Liu et al.

Summary: Carboplatin-resistant RB cells exhibit higher autophagy activity compared to parent cells, leading to multi-drug resistance. This study introduces a new strategy of inducing autophagy-dependent ferroptosis to eliminate drug-resistant RB cells. The effectiveness and safety of a cell-permeable derivative of itaconate in inducing ferritinophagy-dependent ferroptosis were evaluated.

CELL DEATH & DISEASE (2022)

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Article Biotechnology & Applied Microbiology

Multifunctional nanoparticles co-loaded with Adriamycin and MDR-targeting siRNAs for treatment of chemotherapy-resistant esophageal cancer

Xiangyang Zhang et al.

Summary: The development of multidrug resistance (MDR) in cancer chemotherapy is a major challenge. This study identified MVP and BCL2 as potential factors driving MDR in ESCC. A self-assembling nanoparticle platform was designed to deliver Adriamycin and siRNAs targeting MVP and BCL2, reducing drug efflux and promoting apoptosis. The nanoparticles effectively inhibited cancer cell growth and tumor development.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Materials Science, Biomaterials

Matrix Metalloproteinase-2-Responsive Surface-Changeable Liposomes Decorated by Multifunctional Peptides to Overcome the Drug Resistance of Triple-Negative Breast Cancer through Enhanced Targeting and Penetrability

Changliang Liu et al.

Summary: In this study, a surface-variable drug delivery vehicle based on liposomes was developed for treating drug-resistant triple-negative breast cancer (TNBC). The vehicle, called DT-pLip, exhibited superior efficacy in inhibiting tumor growth both in vitro and in vivo through EGFR targeting and MMP-2 induced penetration enhancement.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

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Article Chemistry, Applied

Stepwise responsive carboxymethyl chitosan-based nanoplatform for effective drug-resistant breast cancer suppression

Hui Peng et al.

Summary: In this study, a multi-functional carboxymethyl chitosan (CMC) based core-shell nanoplatform was developed for co-delivery of MDR1 gene-silenced siRNA and doxorubicin (DOX). The nanoplatform could release payloads in an acid/redox triggered fashion and possessed tumor-targeting and endo/lysosomal escape functions. The experimental results showed that the nanoplatform efficiently silenced genes, inhibited P-gp expression, and exhibited synergistic therapeutic effects.

CARBOHYDRATE POLYMERS (2022)

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Review Oncology

DNA damage and metabolic mechanisms of cancer drug resistance

Deanna Tiek et al.

Summary: This review discusses different strategies to combat cancer drug resistance, including synthetic lethality and modulation of the tumor microenvironment. By understanding the relationship between targetable mutations and metabolism in tumor cells and their surrounding microenvironment, smarter drugs can be designed to fight cancer drug resistance.

CANCER DRUG RESISTANCE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

FDG PET correlates weakly with HIF-1α expression in solid tumors: a meta-analysis

Alexey Surov et al.

Summary: The study aimed to provide clear data about the associations between maximum standardized uptake value (SUVmax) and HIF-1 alpha expression in solid tumors. The results showed a weak correlation between SUVmax of FDG PET and HIF-1 alpha in both overall sample and tumor subgroups.

ACTA RADIOLOGICA (2021)

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Review Biotechnology & Applied Microbiology

Regulation of DNA methylation machinery by epi-miRNAs in human cancer: emerging new targets in cancer therapy

Mohammad Reza Karimzadeh et al.

Summary: Disruption in DNA methylation processes can lead to gene expression alterations and malignancy. Regulating DNA methylation machinery through epi-miRNAs may be a promising approach for cancer therapy.

CANCER GENE THERAPY (2021)

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Review Multidisciplinary Sciences

Advances in nanomaterials for treatment of hypoxic tumor

Mei-Zhen Zou et al.

Summary: The hypoxic tumor microenvironment poses challenges for tumor therapy, leading researchers to focus on developing functional nanomaterials to treat hypoxic tumors. These nanomaterials are categorized into those that elevate oxygen levels in tumors and those with diminished oxygen dependence for hypoxic tumor therapy, with discussions on their biocompatibility and therapeutic efficacy.

NATIONAL SCIENCE REVIEW (2021)

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Article Cell Biology

Esomeprazole overcomes paclitaxel-resistance and enhances anticancer effects of paclitaxel by inducing autophagy in A549/Taxol cells

Zhaoshi Bai et al.

Summary: The study found that esomeprazole could enhance the efficacy of paclitaxel in NSCLC cells resistant to the drug by reducing intracellular pH, promoting microtubule polymerization, and increasing apoptosis. This offers a promising new strategy for overcoming paclitaxel resistance in NSCLC treatment.

CELL BIOLOGY INTERNATIONAL (2021)

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Article Pharmacology & Pharmacy

Co-administration of paclitaxel and 2-methoxyestradiol using folate-conjugated human serum albumin nanoparticles for improving drug resistance and antitumor efficacy

Xinyang Liu et al.

Summary: This research successfully reduced multidrug resistance and improved antitumor efficiency by co-encapsulating PTX and 2-ME into FA-HSANPs, showing significant cytotoxicity and apoptosis-inducing activities in PTX-resistant cells. Furthermore, PTX/2-ME@FA-HSANPs exhibited better inhibition of tumor growth in mouse models and reduced pathological damage to normal tissues.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Acidic microenvironment enhances MT1-MMP-mediated cancer cell motility through integrin β1/cofilin/F-actin axis

Lubiao Liang et al.

Summary: The acidic microenvironment enhances cancer cell motility and further exacerbates ECM degradation; in this environment, there are changes in the cell cytoskeleton and potential for a high-invasive phenotype; integrin beta 1 triggers biological responses under acidic microenvironment, enhancing cancer cell motility.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2021)

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Article Engineering, Biomedical

Coadministration of iRGD peptide with ROS-sensitive nanoparticles co-delivering siFGL1 and siPD-L1 enhanced tumor immunotherapy

Wen-Jun Wan et al.

Summary: The study focused on using a novel intelligent nano-delivery system for co-delivery of siFGL1 and siPD-L1, resulting in down-regulation of FGL1 and PD-L1 protein levels in tumor cells. The project proposed a new strategy for tumor immunotherapy based on smart nano-delivery systems, showcasing the potential for nanoparticle-mediated cancer immunotherapy. This research may offer more insights into the effectiveness of nanoparticle delivery in cancer treatment.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

Lian-Hua Fu et al.

Summary: Chemodynamic therapy (CDT) is a promising method for killing cancer cells by converting intracellular hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals ((OH)-O-center dot). An intelligent nanocatalytic theranostics, PGC-DOX, was developed to address the limitations of endogenous H2O2 and high GSH levels in tumor cells, leading to efficient cancer therapy. The system combines H2O2 self-supply, GSH-elimination, and DOX-induced chemotherapy to effectively inhibit tumor growth with minimal side effects in vivo.

ADVANCED MATERIALS (2021)

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Article Engineering, Biomedical

Polyprodrug with glutathione depletion and cascade drug activation for multi-drug resistance reversal

Xuan Xiao et al.

Summary: This study introduces a polyprodrug (PSSD) that can deplete GSH and activate drugs simultaneously, aiming to reverse multidrug resistance. The poly(disulfide) backbone depletes GSH and triggers the activation of DOX through a cascade reaction, showing promising potential in overcoming drug resistance.

BIOMATERIALS (2021)

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Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Chemistry, Multidisciplinary

Redox-responsive polyethyleneimine/tetrahedron DNA/doxorubicin nanocomplexes for deep cell/tissue penetration to overcome multidrug resistance

Jianqin Yan et al.

Summary: The study introduced redox-responsive nanocomplexes for deep penetration into cancer cells and tissues, overcoming multidrug resistance. Results showed that the nanocomplexes could bind to cell membranes, create holes, enhance cellular internalization, and penetrate deep tumor tissues through leakage and infection. In vivo studies demonstrated superior tumor penetration and therapeutic efficiency in drug-resistant tumor models representing different MDR characteristics.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Pharmacology & Pharmacy

Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications

Xiaobin Zeng et al.

Summary: Both hereditary and sporadic breast cancer may stem from a subcomponent of stem cells with dysregulated self-renewal pathways. Cancer stem cells play a crucial role in treatment resistance and tumor initiation, highlighting the importance of therapeutic strategies targeting these cells.

PHARMACOLOGICAL RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Doxorubicin Hydrochloride-Loaded Nonionic Surfactant Vesicles to Treat Metastatic and Non-Metastatic Breast Cancer

Martina Di Francesco et al.

Summary: This study developed nonionic surfactant vesicles (NSVs) loaded with doxorubicin hydrochloride (DOX) to improve therapeutic efficacy and reduce side effects. NSVs showed stable sustained drug release, better internalization and anticancer effect on breast cancer cells. The data suggested that DOX-loaded NSVs could be a promising nanocarrier for the potential treatment of metastatic breast cancer.

ACS OMEGA (2021)

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Article Chemistry, Multidisciplinary

A Near-Infrared-II Polymer with Tandem Fluorophores Demonstrates Superior Biodegradability for Simultaneous Drug Tracking and Treatment Efficacy Feedback

Dengshuai Wei et al.

Summary: This study introduces a highly biodegradable polyester carrying tandem NIR-II fluorophores as a promising alternative for in vivo monitoring of drugs and real-time feedback on therapeutic effects. The polymer encapsulated a platinum intercalator and was conjugated with both a cell-targeting peptide and a caspase-3 cleavable peptide probe for simultaneous NIR-II and apoptosis imaging, demonstrating strong potency in vitro and significant inhibition of tumor growth in a mouse model. Through label-free mass spectrometry imaging, in situ release of the platinum intercalator in deeper tumors was observed.

ACS NANO (2021)

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Article Biochemistry & Molecular Biology

Metformin induced lactic acidosis impaired response of cancer cells towards paclitaxel and doxorubicin: Role of monocarboxylate transporter

Shivendra Vikram Singh et al.

Summary: This study explores the impact of MCT4 mediated extracellular acidosis on the efficacy of chemotherapeutic drugs on cancer cells. The acidic environment caused by altered glucose metabolism interferes with drug uptake and efficacy, but modulation of pH(e) enhances drug cytotoxicity. Inhibition of MCT4 or use of pH neutralizing agents may help overcome the impairment of drug efficacy due to pH changes.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Chemistry, Applied

Chondroitin sulfate-based nanoparticles for enhanced chemo-photodynamic therapy overcoming multidrug resistance and lung metastasis of breast cancer

Xiaoqun Shi et al.

Summary: The study developed novel redox-responsive chondroitin sulfate-based nanoparticles for enhanced chemo-photodynamic therapy to overcome multidrug resistance and lung metastasis of breast cancer. In vitro experiments showed that the nanoparticles were able to down-regulate P-glycoprotein expression and improve anticancer efficacy. Additionally, NIR laser irradiation induced nanoparticles to generate reactive oxygen species, effectively inhibiting multidrug resistance and metastasis in breast cancer.

CARBOHYDRATE POLYMERS (2021)

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Review Cell & Tissue Engineering

Targeting Energy Metabolism in Cancer Stem Cells: Progress and Challenges in Leukemia and Solid Tumors

Courtney L. Jones et al.

Summary: The article explores the significance of malignant stem cells in leukemia and how targeting energy metabolism can offer more effective treatment options for leukemia patients. It discusses the metabolic properties of leukemia stem cells and compares them with malignant stem cells from solid tumors.

CELL STEM CELL (2021)

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Article Chemistry, Multidisciplinary

Multivalent rubber-like RNA nanoparticles for targeted co-delivery of paclitaxel and MiRNA to silence the drug efflux transporter and liver cancer drug resistance

Hongzhi Wang et al.

Summary: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death globally. Liver acts as a filter to detoxify chemicals, while liver cancer cells exhibit drug effluxion leading to chemoresistance. A new multivalent RNA nanoparticle, designed to target liver cancer cells, efficiently delivers therapeutics to the tumor site and shows potential in treating HCC.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Medicine, Research & Experimental

Co-delivery of cisplatin and oleanolic acid by silica nanoparticles-enhanced apoptosis and reverse multidrug resistance in lung cancer

Xiao-Kai Zhang et al.

Summary: The co-loaded DDP and OA in Nsi showed promising results in overcoming DDP-resistance in lung cancer therapy, with significantly higher cytotoxicity and intracellular drug accumulation compared to free DDP or DDP-Nsi. In the A549/DDP xenograft tumor model, DDP/OA-Nsi exhibited the best anticancer effect.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2021)

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Article Materials Science, Biomaterials

Hyaluronic acid (HA)-coated naproxen-nanoparticles selectively target breast cancer stem cells through COX-independent pathways

Eva Espinosa-Cano et al.

Summary: This study investigated the use of hyaluronic acid-coated naproxen polymeric nanoparticles targeting cancer stem cells in metastatic breast cancer. The HA-coating improved drug release control, enhanced hemocompatibility, and displayed strong CSC-targeting efficacy in breast cancer cells. The nano-formulated NAP significantly reduced cell viability and migration, possibly through inducing apoptosis via a GSK-3 beta-related pathway, suggesting potential for improving the treatment of advanced breast cancer.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Nanoscience & Nanotechnology

Biocompatibility and cytotoxicity in vitro of surface-functionalized drug-loaded spinel ferrite nanoparticles

Sadaf Mushtaq et al.

Summary: In this study, PMA-coated spinel ferrite nanoparticles were developed as carriers for anticancer drugs, showing tumor specificity and elevated cytotoxicity in cancer cells. The nanoparticles also inhibited multidrug resistance and exhibited potential for targeted cancer therapy.

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Anti-CD44-Conjugated Olive Oil Liquid Nanocapsules for Targeting Pancreatic Cancer Stem Cells

Saul A. Navarro-Marchal et al.

Summary: The latest trends in cancer research and nanomedicine focus on using nanocarriers to target cancer stem cells (CSCs). Specifically, lipid liquid nanocapsules are usually developed as nanocarriers for lipophilic drug delivery. The development of olive oil liquid NCs functionalized by covalently coupling an anti-CD44 antibody has shown high targeted uptake and increased antitumor efficacy in vitro and in vivo.

BIOMACROMOLECULES (2021)

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Article Biotechnology & Applied Microbiology

A novel targeted co-delivery nanosystem for enhanced ovarian cancer treatment via multidrug resistance reversion and mTOR-mediated signaling pathway

Xueqin Wang et al.

Summary: In this study, a novel nano targeted co-delivery system modified by hyaluronic acid (HA) was developed to overcome multidrug resistance in ovarian cancer by delivering hydrophobic chemotherapy drug Paclitaxel (PTX) and lethal-7a (let-7a) microRNA. The nanosystem demonstrated effective cell uptake and enhanced tumor site permeability, leading to downregulation of P-glycoprotein, PTX release, and apoptosis induction. Additionally, mTOR-mediated signaling pathways played a crucial role in reversing drug resistance and inducing apoptosis, providing a model for overcoming PTX resistance in ovarian cancer.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Oncology

Metabolic adaptation in hypoxia and cancer

Felipe Paredes et al.

Summary: The focus of cells' adaptation to hypoxia is the transcription factor HIF1α, which promotes tumor development by affecting cellular metabolism. In addition to hypoxia, metabolic inhibition also influences HIF1α stability and activity, promoting glycolytic metabolism in cancer cells to support growth and proliferation.

CANCER LETTERS (2021)

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Article Chemistry, Multidisciplinary

Homing Peptide-Based Targeting of Tenascin-C and Fibronectin in Endometriosis

Lorena Simon-Gracia et al.

Summary: The study explores the use of homing peptides for precision delivery of diagnostic and therapeutic compounds to endometriotic lesions. Findings indicate that PL1 peptide can bind to endometriotic cells, showing potential for precision diagnosis and therapy through PL1-guided nanoparticles.

NANOMATERIALS (2021)

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Article Oncology

Hyaluronidase and pH Dual-Responsive Nanoparticles for Targeted Breast Cancer Stem Cells

Weinan Li et al.

Summary: The pH-responsive and CD44 receptor-mediated targeted nanoparticles loaded with Thioridazine showed great potential in eliminating cancer stem cells. In vitro release studies demonstrated effective drug release in acidic pH conditions. Cellular uptake studies confirmed efficient uptake of the nanoparticles in mammospheres, and in vivo distribution studies showed prolonged retention at tumor sites and improved tumor-suppressing effects.

FRONTIERS IN ONCOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Resveratrol-Loaded TPGS-Resveratrol-Solid Lipid Nanoparticles for Multidrug-Resistant Therapy of Breast Cancer: In Vivo and In Vitro Study

Wenrui Wang et al.

Summary: The study successfully formulated TPGS-Res-SLNs nanoparticles to improve therapeutic efficacy against breast cancer, showing significant anti-tumor activity and promotion of cell apoptosis. It also exhibited significant inhibition of cancer cell invasion and migration. In vivo experiments showed that TPGS-Res-SLNs had higher efficacy in promoting tumor cell apoptosis.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Oncology

The hallmarks of ovarian cancer stem cells and niches: Exploring their harmonious interplay in therapy resistance

Takeshi Motohara et al.

Summary: The concept of cancer stem cells has advanced in recent decades, with a focus on their role in tumor heterogeneity and therapeutic resistance. In particular, the interactions between ovarian cancer stem cells and their niches play a key role in chemotherapy resistance in patients with advanced ovarian cancer.

SEMINARS IN CANCER BIOLOGY (2021)

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Article Multidisciplinary Sciences

Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance

Emily L. Giddings et al.

Summary: Chemotherapy is the standard treatment for most cancers worldwide, but chemoresistance due to ABC transporters is a significant challenge. The study highlights the role of mitochondrial respiration in supplying ATP for ABC transporters, and how inhibiting mitochondrial respiration can overcome chemoresistance. Development of MCJ mimetics offers a potential alternative strategy for treating multiple cancers by targeting this mechanism.

NATURE COMMUNICATIONS (2021)

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Article Biotechnology & Applied Microbiology

Effects of the surface charge of polyamidoamine dendrimers on cellular exocytosis and the exocytosis mechanism in multidrug-resistant breast cancer cells

Jie Zhang et al.

Summary: This study investigated the exocytosis rule and mechanism of PAMAM dendrimers in multidrug-resistant tumor cells. The results showed that positively charged PAMAM-NH2 had the highest exocytosis rate and was attracted to the mitochondria and cell nuclei. Intracellular transportation processes, attraction to the mitochondria and cell nucleus, as well as nuclear efflux generated by MVP were major factors contributing to the exocytosis of PAMAM-NH2.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Nanoscience & Nanotechnology

Glutathione-Activated NO-/ROS-Generation Nanoparticles to Modulate the Tumor Hypoxic Microenvironment for Enhancing the Effect of HIFU-Combined Chemotherapy

Qianyan Li et al.

Summary: The combination of HIFU and chemotherapy has promising potential in treating solid tumors, but the hypoxic tumor microenvironment can impede clinical efficacy. This study developed nanoparticles capable of generating NO and ROS at the tumor site to relieve hypoxia, sensitizing solid tumors for chemotherapy and showing considerable potential in the management of hypoxic solid tumors.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

TPGS-Galactose-Modified Polydopamine Co-delivery Nanoparticles of Nitric Oxide Donor and Doxorubicin for Targeted Chemo-Photothermal Therapy against Drug-Resistant Hepatocellular Carcinoma

Zijing Du et al.

Summary: The study successfully addressed the challenges of lack of cancer cell specificity and multidrug resistance in the treatment of hepatocellular carcinoma (HCC) by utilizing a novel nanoparticle-based drug delivery system. This system not only targeted drug delivery to liver cells but also reversed multidrug resistance, demonstrating potent anti-cancer activity.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

Tumor-targeting pH/redox dual-responsive nanosystem epigenetically reverses cancer drug resistance by co-delivering doxorubicin and GCN5 siRNA

Ye Yuan et al.

Summary: A tumor-targeting, pH/redox dual-responsive nanosystem was designed for the co-delivery of chemo-drugs and siRNA. This nanosystem efficiently delivered DOX and siGCN5 into drug-resistant cancer cells, inhibiting tumor growth significantly and downregulating P-gp epigenetically. In an MDR breast tumor model, DOX and siGCN5 loaded HPMSNs effectively inhibited tumor growth, abolished P-gp expression, and minimized DOX's systemic toxicity.

ACTA BIOMATERIALIA (2021)

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Article Engineering, Biomedical

Amplification of tumor oxidative stresses by Poly(disulfide acetal) for multidrug resistance reversal

Qingyu Zong et al.

Summary: The study developed a novel polymer that can overcome multidrug resistance in cancer cells by increasing oxidative stress. By inhibiting ATP production, the polymer makes resistant cells more susceptible to anticancer drugs, effectively reversing multidrug resistance.

BIOMATERIALS (2021)

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Review Pharmacology & Pharmacy

Novel nanomedicines to overcome cancer multidrug resistance

Zhenwei Su et al.

Summary: Chemotherapy is powerful in eliminating malignant cells, but its efficacy is often hindered by drug resistance. Nanomedicine, focusing on targeted drug delivery to tumor tissues using nano-sized formulations, shows promise in improving treatment outcomes, minimizing adverse effects, and overcoming cancer drug resistance. This approach involves strategies such as passive and active targeted delivery, delivering multidrug combinations, and multimodal combination therapy to pave the way for effective cancer treatment and holds great potential in overcoming drug resistance.

DRUG RESISTANCE UPDATES (2021)

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Article Biochemistry & Molecular Biology

TPGS and chondroitin sulfate dual-modified lipid-albumin nanosystem for targeted delivery of chemotherapeutic agent against multidrug-resistant cancer

Kaipei Luo et al.

Summary: A dual-modified lipid albumin nanosystem was developed for targeted delivery of paclitaxel to treat multidrug-resistant cancer. The system showed improved intracellular accumulation of the drug and demonstrated excellent antitumor efficacy by inhibiting cell proliferation through controlled drug release within cells. In vivo studies confirmed elevated tumor accumulation and significant survival benefits in tumor-bearing mice, showcasing the potential of this system for targeted chemotherapy and overcoming multidrug resistance in cancer treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Biochemistry & Molecular Biology

The Influence of Cell Cycle Regulation on Chemotherapy

Ying Sun et al.

Summary: Cell cycle regulation is crucial for cell proliferation, growth, and repair, and closely related to tumor occurrence and development. Chemotherapy can synergize with cell cycle regulation to improve sensitivity of tumor cells to chemotherapeutic drugs in cancer treatment. Collaborative strategies of chemotherapy and cell cycle regulation are discussed, along with challenges and perspectives for improving combination strategies for cancer therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Chemistry, Multidisciplinary

In-vitro tumor microenvironment models containing physical and biological barriers for modelling multidrug resistance mechanisms and multidrug delivery strategies

Mehdi Rahmanian et al.

Summary: The complexity and heterogeneity of the 3D tumor microenvironment pose challenges to tumor studies and treatment. Traditional tumor models are limited in simulating resistance mechanisms, while new technologies have potential for simulating the 3D tumor microenvironment and identifying mechanisms underlying multidrug resistance.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Medicine, Research & Experimental

Nanotherapeutic approach to tackle chemotherapeutic resistance of cancer stem cells

Bruna Stefane Alves de Oliveira et al.

Summary: Cancer is projected to become the leading cause of mortality worldwide in the future, with tumorigenesis being a complex process involving cancer stem cells playing a significant role. Research on targeting CSCs in cancer treatment is on the rise, showing promising results in pathways and CSC-surface markers targeting.

LIFE SCIENCES (2021)

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Article Pharmacology & Pharmacy

Doxorubicin/Nucleophosmin Binding Protein-Conjugated Nanoparticle Enhances Anti-leukemia Activity in Acute Lymphoblastic Leukemia Cells in vitro and in vivo

Donghui Gan et al.

Summary: DOX-PMs-NPMBP demonstrates significant anti-leukemia potential in resistant ALL cells by enhancing chemosensitivity to DOX and inducing apoptosis. This novel drug delivery system may be valuable for developing new therapeutic strategies against multidrug resistant ALL.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Chemistry, Multidisciplinary

Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells: A Review of Recent Advances

Yavuz Nuri Ertas et al.

Summary: Cancer stem cells (CSCs) play a crucial role in tumor growth, metastasis, recurrence, and drug resistance. They are maintained within a niche by unique factors in the microenvironment. Using nanoparticles as carriers for anticancer drugs enables targeted delivery to CSCs, contributing to advancements in cancer therapy.

NANOMATERIALS (2021)

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Review Oncology

Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance

Christiana M. Neophytou et al.

Summary: This review discusses the deregulation of apoptotic pathways as a key factor leading to multidrug resistance (MDR) in cancer cells, along with the impact of the tumor microenvironment on apoptosis in MDR tumors. Therapeutic approaches targeting Bcl-2 family members, IAPs, and AKT, as well as the potential of epigenetic modifications in reversing MDR, are highlighted as important strategies against drug resistance.

CANCERS (2021)

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Article Pharmacology & Pharmacy

M1 Macrophage-Derived Exosomes Loaded with Gemcitabine and Deferasirox against Chemoresistant Pancreatic Cancer

Yongmei Zhao et al.

Summary: This study developed a specific drug delivery system based on M1 macrophage-derived exosomes for pancreatic cancer with chemoresistance. The nanoformulation combining GEM and DFX in M1Exo significantly enhanced therapeutic efficacy against GEM-resistant cancer cells.

PHARMACEUTICS (2021)

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Review Engineering, Chemical

Challenges towards Targeted Drug Delivery in Cancer Nanomedicines

Muhammad Nadeem Hafeez et al.

Summary: Despite thirty years of development in cancer nanomedicine, there are still serious disadvantages that need to be addressed. Future directions may involve focusing on personalized treatment and designing multifunctional targeted nano-drug delivery systems for enhanced therapeutic effects.

PROCESSES (2021)

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Article Cell Biology

Surface PEGylated Cancer Cell Membrane-Coated Nanoparticles for Codelivery of Curcumin and Doxorubicin for the Treatment of Multidrug Resistant Esophageal Carcinoma

Yi Gao et al.

Summary: In this study, a targeted biomimetic nano-drug delivery system PMPNs was successfully prepared, which overcome the MDR of esophageal carcinoma by co-delivering DOX and sensitizer curcumin. PMPNs could directly target TE10 and TE10/DOX cells or TE10/DOX xenografted tumor and effectively inhibit the growth of DOX-resistant esophageal carcinoma. Besides, the PMPNs was confirmed to have high biosafety.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Nanoscience & Nanotechnology

Nanoparticles for Cancer Therapy: Current Progress and Challenges

Shreelaxmi Gavas et al.

Summary: Nanotechnology has revolutionized cancer diagnosis and treatment by overcoming limitations of traditional therapies and multidrug resistance. Nanoparticles, with their unique advantages, offer new perspectives for cancer treatment. However, challenges still exist in research and clinical translation of nanotherapeutics.

NANOSCALE RESEARCH LETTERS (2021)

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Review Biochemistry & Molecular Biology

Cancer models in preclinical research: A chronicle review of advancement in effective cancer research

Humna Sajjad et al.

Summary: Cancer models are essential tools in cancer research, providing insights into cancer development and progression, as well as guiding treatment strategies. Despite their limitations, these models are crucial for developing new therapies and drugs for cancer, bridging the gap between basic research and clinical application for a brighter future in cancer treatment.

ANIMAL MODELS AND EXPERIMENTAL MEDICINE (2021)

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Article Materials Science, Biomaterials

CD133 peptide-conjugated pyropheophorbide-a as a novel photosensitizer for targeted photodynamic therapy in colorectal cancer stem cells

Shichao Yan et al.

Summary: The study demonstrates that the novel photosensitizer CD133-Pyro can enhance the targeting properties for treating CRC, showing therapeutic effects on CRC CSCs by promoting ROS production, suppressing stemness properties, and inducing autophagic cell death. CD133-Pyro PDT has a significant inhibitory effect on CRC CSC-derived xenograft tumors in nude mice.

BIOMATERIALS SCIENCE (2021)

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Article Pharmacology & Pharmacy

Nanoliposomes as Multidrug Carrier of Gemcitabine/Paclitaxel for the Effective Treatment of Metastatic Breast Cancer Disease: A Comparison with Gemzar and Taxol

Christian Celia et al.

Summary: Nanoliposomes co-delivering gemcitabine hydrochloride and paclitaxel significantly decrease cell viability, reduce tumor growth and improve survival times in metastatic breast cancer compared to combination treatment with the free drugs. Pharmacokinetic analysis shows that nanoliposomes increase the half-life of gemcitabine hydrochloride and paclitaxel, suggesting an effective treatment strategy for metastatic breast cancer.

ADVANCED THERAPEUTICS (2021)

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Review Pharmacology & Pharmacy

Computational approaches in cancer multidrug resistance research: Identification of potential biomarkers, drug targets and drug-target interactions

A. Tolios et al.

DRUG RESISTANCE UPDATES (2020)

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Article Engineering, Biomedical

ROS and GSH-responsive S-nitrosoglutathione functionalized polymeric nanoparticles to overcome multidrug resistance in cancer

Wen Wu et al.

ACTA BIOMATERIALIA (2020)

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Article Medicine, Research & Experimental

Dual delivery nanoscale device for miR-451 and adriamycin co-delivery to combat multidrug resistant in bladder cancer

Shuguang Wei et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Engineering, Environmental

Ultrasmall platinum nanoparticles enable deep tumor penetration and synergistic therapeutic abilities through free radical species-assisted catalysis to combat cancer multidrug resistance

Ranjith Kumar Kankala et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Review Pharmacology & Pharmacy

Advanced technological tools to study multidrug resistance in cancer

Luca Andrei et al.

DRUG RESISTANCE UPDATES (2020)

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Article Pharmacology & Pharmacy

Folate-Gold-Bilirubin Nanoconjugate Induces Apoptotic Death in Multidrug-Resistant Oral Carcinoma Cells

Pierson Rathinaraj et al.

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS (2020)

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Review Biochemistry & Molecular Biology

Overcoming multidrug resistance in cancer: Recent progress in nanotechnology and new horizons

Maryam Majidinia et al.

IUBMB LIFE (2020)

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Review Pharmacology & Pharmacy

Long non-coding RNAs as a determinant of cancer drug resistance: Towards the overcoming of chemoresistance via modulation of lncRNAs

Wenxiao Jiang et al.

DRUG RESISTANCE UPDATES (2020)

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Review Pharmacology & Pharmacy

Nanomedicine to target multidrug resistant tumors

Elise Lepeltier et al.

DRUG RESISTANCE UPDATES (2020)

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Review Biochemistry & Molecular Biology

Mechanisms of Multidrug Resistance in Cancer Chemotherapy

Karol Bukowski et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling

Renlun Huang et al.

CELL DEATH & DISEASE (2020)

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Article Nanoscience & Nanotechnology

PD-L1 monoclonal antibody-decorated nanoliposomes loaded with Paclitaxel and P-gp transport inhibitor for the synergistic chemotherapy against multidrug resistant gastric cancers

Jinling Yu et al.

NANOSCALE RESEARCH LETTERS (2020)

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Article Cell & Tissue Engineering

Dishevelled I -Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma

Wen-Ying Liao et al.

STEM CELL REPORTS (2020)

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Article Nanoscience & Nanotechnology

Photosensitizer-Doped and Plasma Membrane-Responsive Liposomes for Nuclear Drug Delivery and Multidrug Resistance Reversal

Ya-Xuan Zhu et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Biochemistry & Molecular Biology

Combinatory Treatment with miR-7-5p and Drug-Loaded Cubosomes Effectively Impairs Cancer Cells

Ewa Gajda et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Pharmacology & Pharmacy

Lipid/Hyaluronic Acid-Coated Doxorubicin-Fe3O4 as a Dual-Targeting Nanoparticle for Enhanced Cancer Therapy

Jinying Liang et al.

AAPS PHARMSCITECH (2020)

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Article Chemistry, Multidisciplinary

What Went Wrong with Anticancer Nanomedicine Design and How to Make It Right

Duxin Sun et al.

ACS NANO (2020)

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Article Oncology

Hypoxia-responsive nanoparticles for tumor-targeted drug delivery

Yuce Li et al.

CANCER LETTERS (2020)

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Review Pharmacology & Pharmacy

Repurposing old drugs to fight multidrug resistant cancers

Jelena Dinic et al.

DRUG RESISTANCE UPDATES (2020)

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Review Biochemistry & Molecular Biology

Role of Glutathione in Cancer: From Mechanisms to Therapies

Luke Kennedy et al.

BIOMOLECULES (2020)

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Article Nanoscience & Nanotechnology

Reversing P-Glycoprotein-Associated Multidrug Resistance of Breast Cancer by Targeted Acid-Cleavable Polysaccharide Nanoparticles with Lapatinib Sensitization

Junhui Sui et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Pharmacology & Pharmacy

Hypoxia-sensitive micellar nanoparticles for co-delivery of siRNA and chemotherapeutics to overcome multi-drug resistance in tumor cells

Ujjwal Joshi et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Oncology

Differentiated cancer cell-originated lactate promotes the self-renewal of cancer stem cells in patient-derived colorectal cancer organoids

Hui Zhao et al.

CANCER LETTERS (2020)

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Article Pharmacology & Pharmacy

A pH/ROS cascade-responsive and self-accelerating drug release nanosystem for the targeted treatment of multi-drug-resistant colon cancer

Na Chang et al.

DRUG DELIVERY (2020)

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Article Materials Science, Biomaterials

DOX-loaded peptide dendritic copolymer nanoparticles for combating multidrug resistance by regulating the lysosomal pathway of apoptosis in breast cancer cells

Jianxi Wang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Biochemistry & Molecular Biology

Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release

Ali Raza et al.

MOLECULES (2019)

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Review Biochemistry & Molecular Biology

Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance

Selma Maacha et al.

MOLECULAR CANCER (2019)

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Review Chemistry, Multidisciplinary

Carriers Break Barriers in Drug Delivery: Endocytosis and Endosomal Escape of Gene Delivery Vectors

Isabelle M. S. Degors et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Article Oncology

Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells

Manoj Amrutkar et al.

BMC CANCER (2019)

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Article Nanoscience & Nanotechnology

Tumor-targeted drug delivery and sensitization by MMP2-responsive polymeric micelles

Qing Yao et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

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Review Biochemistry & Molecular Biology

The biochemical and molecular mechanisms involved in the role of tumor micro-environment stress in development of drug resistance

Lina Al-Akra et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2019)

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Article Biophysics

Co-delivery of DOX and PDTC by pH-sensitive nanoparticles to overcome multidrug resistance in breast cancer

Xu Cheng et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Review Pharmacology & Pharmacy

The multi-factorial nature of clinical multidrug resistance in cancer

Yehuda G. Assaraf et al.

DRUG RESISTANCE UPDATES (2019)

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Article Chemistry, Multidisciplinary

Nitric Oxide Stimulated Programmable Drug Release of Nanosystem for Multidrug Resistance Cancer Therapy

Li Wang et al.

NANO LETTERS (2019)

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Article Biophysics

Polydopamine coated hollow mesoporous silica nanoparticles as pH-sensitive nanocarriers for overcoming multidrug resistance

Mei Shao et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Oncology

Proton Pump Inhibitors Modulate Transport Of Doxorubicin And Its Liposomal Form Into 2D And 3D Breast Cancer Cell Cultures

Migle Paskeviciute et al.

CANCER MANAGEMENT AND RESEARCH (2019)

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Article Genetics & Heredity

Synergistic Chemotherapy Drug Response Is a Genetic Trait in Lymphoblastoid Cell Lines

Kyle R. Roell et al.

FRONTIERS IN GENETICS (2019)

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Article Chemistry, Medicinal

Design and synthesis of mixed micellar system for enhanced anticancer efficacy of Paclitaxel through its co-delivery with Naringin

Tooba Jabri et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2019)

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Article Engineering, Biomedical

Functional extracellular vesicles engineered with lipid-grafted hyaluronic acid effectively reverse cancer drug resistance

Jia Liu et al.

BIOMATERIALS (2019)

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Article Chemistry, Multidisciplinary

Fucoidan-coated coral-like Pt nanoparticles for computed tomography-guided highly enhanced synergistic anticancer effect against drug-resistant breast cancer cells

Seounghun Kang et al.

NANOSCALE (2019)

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Article Nanoscience & Nanotechnology

Light-Activated ROS-Responsive Nanoplatform Codelivering Apatinib and Doxorubicin for Enhanced Chemo-Photodynamic Therapy of Multidrug-Resistant Tumors

Xiao Wei et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Engineering, Biomedical

Dual-targeting Wnt and uPA receptors using peptide conjugated ultra-small nanoparticle drug carriers inhibited cancer stem-cell phenotype in chemo-resistant breast cancer

Jasmine Miller-Kleinhenz et al.

BIOMATERIALS (2018)

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Review Medicine, Research & Experimental

Stimuli-Responsive Nanomedicines for Overcoming Cancer Multidrug Resistance

Lei Zhou et al.

THERANOSTICS (2018)

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Article Chemistry, Multidisciplinary

Synergistic combination chemotherapy using carrier-free celastrol and doxorubicin nanocrystals for overcoming drug resistance

Yating Xiao et al.

NANOSCALE (2018)

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Review Chemistry, Multidisciplinary

Stimuli-Responsive Nano-Architecture Drug-Delivery Systems to Solid Tumor Micromilieu: Past, Present, and Future Perspectives

Hossam S. El-Sawy et al.

ACS NANO (2018)

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Review Oncology

Crosstalk in cancer resistance and metastasis

Saeed Norouzi et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2018)

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Review Pharmacology & Pharmacy

Modulating ROS to overcome multidrug resistance in cancer

Qingbin Cui et al.

DRUG RESISTANCE UPDATES (2018)

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Article Pharmacology & Pharmacy

Dual-modified cationic liposomes loaded with paclitaxel and survivin siRNA for targeted imaging and therapy of cancer stem cells in brain glioma

Xiyang Sun et al.

DRUG DELIVERY (2018)

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Article Engineering, Biomedical

Quercetin-Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells

Zehua Liu et al.

ADVANCED HEALTHCARE MATERIALS (2017)

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Review Pharmacology & Pharmacy

Co-delivery strategies to overcome multidrug resistance in ovarian cancer

Ikram Ullah Khan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Article Nanoscience & Nanotechnology

pH, redox and photothermal tri-responsive DNA/polyethylenimine conjugated gold nanorods as nanocarriers for specific intracellular co-release of doxorubicin and chemosensitizer pyronaridine to combat multidrug resistant cancer

Yun Wang et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

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Review Oncology

Novel strategies to prevent the development of multidrug resistance (MDR) in cancer

Jinglu Wang et al.

ONCOTARGET (2017)

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Article Materials Science, Biomaterials

Overcoming multidrug resistance through co-delivery of ROS-generating nano-machinery in cancer therapeutics

Ranjith Kumar Kankala et al.

JOURNAL OF MATERIALS CHEMISTRY B (2017)

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Review Chemistry, Analytical

The Use of Microfluidics in Cytotoxicity and Nanotoxicity Experiments

Scott C. McCormick et al.

MICROMACHINES (2017)

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Review Pharmacology & Pharmacy

Nanopreparations for mitochondria targeting drug delivery system: Current strategies and future prospective

Zhenjie Wang et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Article Multidisciplinary Sciences

Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles

Vanessa Lopes-Rodrigues et al.

SCIENTIFIC REPORTS (2017)

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Article Nanoscience & Nanotechnology

Exploration of Zinc Oxide Nanoparticles as a Multitarget and Multifunctional Anticancer Nanomedicine

Jiao Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Engineering, Biomedical

Co-delivery of oxygen and erlotinib by aptamer-modified liposomal complexes to reverse hypoxia-induced drug resistance in lung cancer

Fengqiao Li et al.

BIOMATERIALS (2017)

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Review Pharmacology & Pharmacy

The Different Mechanisms of Cancer Drug Resistance: A Brief Review

Behzad Mansoori et al.

ADVANCED PHARMACEUTICAL BULLETIN (2017)

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Article Nanoscience & Nanotechnology

A Versatile Carbonic Anhydrase IX Targeting Ligand-Functionalized Porous Silicon Nanoplatform for Dual Hypoxia Cancer Therapy and Imaging

Agne Janoniene et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Chemistry, Multidisciplinary

Near-Infrared Laser-Triggered Nitric Oxide Nanogenerators for the Reversal of Multidrug Resistance in Cancer

Ranran Guo et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

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Review Pharmacology & Pharmacy

Targeted nanomedicine for cancer therapeutics: Towards precision medicine overcoming drug resistance

Maya Bar-Zeev et al.

DRUG RESISTANCE UPDATES (2017)

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Article Medicine, Research & Experimental

Hyaluronic acid decorated pluronic P85 solid lipid nanoparticles as a potential carrier to overcome multidrug resistance in cervical and breast cancer

Fang Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

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Review Pharmacology & Pharmacy

Engineered Nanoparticles Against MDR in Cancer: The State of the Art and its Prospective

Javed Ahmad et al.

CURRENT PHARMACEUTICAL DESIGN (2016)

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Article Pharmacology & Pharmacy

Solid lipid nanoparticles co-loaded with doxorubicin and α-tocopherol succinate are effective against drug-resistant cancer cells in monolayer and 3-D spheroid cancer cell models

Mariana S. Oliveira et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

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Article Oncology

Effective elimination of liver cancer stem-like cells by CD90 antibody targeted thermosensitive magnetoliposomes

Rui Yang et al.

ONCOTARGET (2016)

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Review Biotechnology & Applied Microbiology

NANOMEDICINE: will it offer possibilities to overcome multiple drug resistance in cancer?

Sten Friberg et al.

JOURNAL OF NANOBIOTECHNOLOGY (2016)

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Article Multidisciplinary Sciences

3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained

Michele Zanoni et al.

SCIENTIFIC REPORTS (2016)

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Article Nanoscience & Nanotechnology

TPGS2k/PLGA Nanoparticles for Overcoming Multidrug Resistance by Interfering Mitochondria of Human Alveolar Adenocarcinoma Cells

Dong-Fang Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

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Article Engineering, Biomedical

Reversal of doxorubicin resistance in breast cancer by mitochondria-targeted pH-responsive micelles

Pengcheng Yu et al.

ACTA BIOMATERIALIA (2015)

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Article Chemistry, Multidisciplinary

Inhibition of Multidrug Resistance of Cancer Cells by Co-Delivery of DNA Nanostructures and Drugs Using Porous Silicon Nanoparticles@Giant Liposomes

Feng Kong et al.

ADVANCED FUNCTIONAL MATERIALS (2015)

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Article Engineering, Biomedical

Reversion of multidrug resistance by a pH-responsive cyclodextrin-derived nanomedicine in drug resistant cancer cells

Qing Shi et al.

BIOMATERIALS (2015)

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Article Engineering, Biomedical

Overcoming drug-resistant lung cancer by paclitaxel loaded dual-functional liposomes with mitochondria targeting and pH-response

Lei Jiang et al.

BIOMATERIALS (2015)

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Review Oncology

Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp

Khalid O. Alfarouk et al.

CANCER CELL INTERNATIONAL (2015)

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Review Chemistry, Medicinal

Targeting autophagy to overcome drug resistance in cancer therapy

Ankit Kumar et al.

FUTURE MEDICINAL CHEMISTRY (2015)

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Review Cell Biology

Cancer stem cells in glioblastoma

Justin D. Lathia et al.

GENES & DEVELOPMENT (2015)

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Review Biochemistry & Molecular Biology

Targeting the DNA Damage Response in Cancer

Mark J. O'Connor

MOLECULAR CELL (2015)

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Review Biotechnology & Applied Microbiology

Nano carriers that enable co-delivery of chemotherapy and RNAi agents for treatment of drug-resistant cancers

Vasilios Tsouris et al.

BIOTECHNOLOGY ADVANCES (2014)

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Article Oncology

Functional characteristics of cancer stem cells and their role in drug resistance of prostate cancer

Viviana Castillo et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

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Review Pharmacology & Pharmacy

Nanopreparations to overcome multidrug resistance in cancer

Niravkumar R. Patel et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

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Review Pharmacology & Pharmacy

Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor

Qi Yin et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

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Review Pharmacology & Pharmacy

Targeting the Bcl-2 family for cancer therapy

Shibu Thomas et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2013)

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Review Multidisciplinary Sciences

Tumour heterogeneity and cancer cell plasticity

Corbin E. Meacham et al.

NATURE (2013)

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Article Multidisciplinary Sciences

Evaluating cell lines as tumour models by comparison of genomic profiles

Silvia Domcke et al.

NATURE COMMUNICATIONS (2013)

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Article Oncology

Identification of unique synergistic drug combinations associated with downexpression of survivin in a preclinical breast cancer model system

Daniel R. Budman et al.

ANTI-CANCER DRUGS (2012)

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Review Pharmacology & Pharmacy

Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapy

Priyambada Parhi et al.

DRUG DISCOVERY TODAY (2012)

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Article Biochemistry & Molecular Biology

Modulation of Mitochondrial Permeability Transition Pore Affects Multidrug Resistance in Human Hepatocellular Carcinoma Cells

Xianlong Ling et al.

International Journal of Biological Sciences (2012)

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Review Cell Biology

MiR-122 in hepatic function and liver diseases

Jun Hu et al.

PROTEIN & CELL (2012)

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Article Oncology

Multidrug Resistance Gene (MDR-1) and Risk of Brain Metastasis in Epithelial Ovarian, Fallopian Tube, and Peritoneal Cancer

Koji Matsuo et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2011)

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Editorial Material Toxicology

Alternatives to animal testing: current status and future perspectives

Manfred Liebsch et al.

ARCHIVES OF TOXICOLOGY (2011)

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Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

CELL (2011)

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Article Cell & Tissue Engineering

Nodal/Activin Signaling Drives Self-Renewal and Tumorigenicity of Pancreatic Cancer Stem Cells and Provides a Target for Combined Drug Therapy

Enza Lonardo et al.

CELL STEM CELL (2011)

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Review Pharmacology & Pharmacy

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